ID   A0A2A2L529_9BILA        Unreviewed;       884 AA.
AC   A0A2A2L529;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Hormone-sensitive lipase {ECO:0008006|Google:ProtNLM};
GN   ORFNames=WR25_14542 {ECO:0000313|EMBL:PAV81167.1};
OS   Diploscapter pachys.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX   NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV81167.1, ECO:0000313|Proteomes:UP000218231};
RN   [1] {ECO:0000313|EMBL:PAV81167.1, ECO:0000313|Proteomes:UP000218231}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PF1309 {ECO:0000313|EMBL:PAV81167.1};
RA   Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA   Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT   "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL   Curr. Biol. 0:0-0(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAV81167.1}.
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DR   EMBL; LIAE01007195; PAV81167.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A2L529; -.
DR   STRING; 2018661.A0A2A2L529; -.
DR   Proteomes; UP000218231; Unassembled WGS sequence.
DR   GO; GO:0016298; F:lipase activity; IEA:InterPro.
DR   GO; GO:0008203; P:cholesterol metabolic process; IEA:InterPro.
DR   GO; GO:0016042; P:lipid catabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 2.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR013094; AB_hydrolase_3.
DR   InterPro; IPR010468; HSL_N.
DR   PANTHER; PTHR23025:SF3; HORMONE-SENSITIVE LIPASE; 1.
DR   PANTHER; PTHR23025; TRIACYLGLYCEROL LIPASE; 1.
DR   Pfam; PF07859; Abhydrolase_3; 2.
DR   Pfam; PF06350; HSL_N; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218231}.
FT   DOMAIN          22..319
FT                   /note="Hormone-sensitive lipase N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF06350"
FT   DOMAIN          337..480
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   DOMAIN          768..855
FT                   /note="Alpha/beta hydrolase fold-3"
FT                   /evidence="ECO:0000259|Pfam:PF07859"
FT   REGION          573..593
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          680..700
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   884 AA;  98911 MW;  691998324E2CD9B1 CRC64;
     MIDRQPLGHR LSVNRNAIHI LLNELCIENE DYYDRAHDDS EYTSRMSTVF PRLQTLMTRL
     KNLIPQLQEV APHYDFDEKT PGNGYRSLIC ICDTVTLHVI ALLKIVYEQK STFTFRYSHY
     CKELEAYATV VEYLCQAIPL CLQVAHSLPQ GSLFPPLEGS YDSYHEMLKG FEKMDSTIFY
     GRPLGFQFSP SVNRVFRIIG VILASYSLTW EKGQGKLGSL INTGRFFLSP EQRASRIIKV
     TKEADINFCK GFWNLSELTN NMPKFFCPNM AVNELREINW VGPITMETSS GGTVKIPEPS
     AHTGPRPVKY RIFSAVNRQH VSPSSASNIQ PPSKYLVIHC HGGGYVATSS KSHETYLRVW
     AKLLNCTVVS IEYSLAPENP FPRPTEEVLF AYAWMINNPQ LVGWTGEKLC MVGDSAGGNL
     IMSVNLRLIE LNVKRKPDGL VPVYTPFLFQ YLPSPSRMLS VMDPLLHMGV VLRCVAAYTG
     AYGKHNKQEN TVNEQTTHRS LQDYVDQVQK QRIEFEGGSQ SIVSLVQGNG HDYKISPQNG
     NSYFITEQNN EANGVQKNGK ALMKGETIEV IETTTDEDNS SEDDEADTTS ISSVHVESDP
     YRIQLTETLC DGQLLDFLIK HPATKDQLTM INENGETIED GVEAMKFENN DSHSEDSITT
     NNNNNVVKRP KLLSMISIGS RKSSQNGNSN SATAPTTPYE NHANGHRTIA SSLSVHSFPM
     TSVHTKRSIS QSLADTAVMA AGHAIDNLQD WLEKPTKHKL ERTTSHKEPQ MVKTPTETKS
     HLLELLSNSS VPRDPLISPM YASDEVIRQL PPIYFVACHL DPLLDDTIEF AKKLRAAGGK
     VGSIDLLPSV PHGFLNFTMM SPECRQGAKI CLQRIKQALG FNLS
//