ID A0A2A2L5D8_9BILA Unreviewed; 747 AA.
AC A0A2A2L5D8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=Nuclear receptor domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_16617 {ECO:0000313|EMBL:PAV81481.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV81481.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV81481.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV81481.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV81481.1}.
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DR EMBL; LIAE01007166; PAV81481.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2L5D8; -.
DR STRING; 2018661.A0A2A2L5D8; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR CDD; cd06966; NR_DBD_CAR; 1.
DR Gene3D; 3.30.50.10; Erythroid Transcription Factor GATA-1, subunit A; 1.
DR Gene3D; 1.10.565.10; Retinoid X Receptor; 1.
DR InterPro; IPR035500; NHR-like_dom_sf.
DR InterPro; IPR000536; Nucl_hrmn_rcpt_lig-bd.
DR InterPro; IPR001628; Znf_hrmn_rcpt.
DR InterPro; IPR013088; Znf_NHR/GATA.
DR PANTHER; PTHR24082; NUCLEAR HORMONE RECEPTOR; 1.
DR PANTHER; PTHR24082:SF283; NUCLEAR HORMONE RECEPTOR HR96; 1.
DR Pfam; PF00105; zf-C4; 1.
DR PRINTS; PR00047; STROIDFINGER.
DR SMART; SM00399; ZnF_C4; 1.
DR SUPFAM; SSF57716; Glucocorticoid receptor-like (DNA-binding domain); 1.
DR SUPFAM; SSF48508; Nuclear receptor ligand-binding domain; 1.
DR PROSITE; PS51843; NR_LBD; 1.
DR PROSITE; PS00031; NUCLEAR_REC_DBD_1; 1.
DR PROSITE; PS51030; NUCLEAR_REC_DBD_2; 1.
PE 4: Predicted;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleus {ECO:0000256|ARBA:ARBA00023242};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 69..144
FT /note="Nuclear receptor"
FT /evidence="ECO:0000259|PROSITE:PS51030"
FT DOMAIN 538..747
FT /note="NR LBD"
FT /evidence="ECO:0000259|PROSITE:PS51843"
FT REGION 274..297
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 747 AA; 82704 MW; 19F213EFA6C41AB3 CRC64;
MGRVGVAIFR PVNISAGKLY KWWYIRRLSI PELRAELASF GGSRLSTQVF IPRANTSSSG
GGNERRIANK ICRVCGDKAF SYNFNVITCE SCKAFFRRNA NKEKEIRCPF NERCEINVVS
RRFCQRCRLA KCFEVGMKKE WIMSDEARLE KKARVEENRE RRIQDAMRRR QNEPEIVDAR
EQRYMQRNRV KSESRGDKEE QLPLSLREFV LTNSINDMPL AAPPPAAEIA AQLGASPTCA
SHLLMDPIPT TAAHSLADVN AQINCLSTMD VDPSTTMSSN GFLPPSVPDS NHQPGPSSVS
AGILPVNVTN AVESSLMAQA QLAAAQVQVQ AAINHQQHQI AAAVVAQQVA AQMATVAPVQ
TAPTPVIPPL SQTITPQMTV PILTPSVPPP AAILSISSPM NPDMVTIPRE IFMKLMENNS
QRSGRCICQC ACGRYPPGSV IVDEVTRDLV AAGNNSASSE TSKEETKLET AEDFQRNGLL
PSDDSSVQWL NTSAPVVDPS GIMEERPTGR RDSIYKSPID RQGNLAVEDN EFSPLTQPDH
ERLSEVLSSN STCNPVAYES SHCWVINFDT GIERMVRMCK TLAPFRALTF DDQFTLVKNS
CLPYLVIRAV VRPDPTVSAS GYPLTEADAP SALDAFLEDA AKLFSGIRDD VREHEGAMLV
FALLCMFDAM DLQLNDADIV NREFDAYLRL LKRLLYSSLN DVVSCSTEIR SLFETLSNIR
EHSMRLYDLI DSASPHLLHP TLRQLLQ
//
