ID A0A2A2L833_9BILA Unreviewed; 942 AA.
AC A0A2A2L833;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 03-MAY-2023, entry version 15.
DE RecName: Full=Ig-like domain-containing protein {ECO:0000259|PROSITE:PS50835};
GN ORFNames=WR25_16766 {ECO:0000313|EMBL:PAV82332.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV82332.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV82332.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV82332.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV82332.1}.
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DR EMBL; LIAE01007064; PAV82331.1; -; Genomic_DNA.
DR EMBL; LIAE01007064; PAV82332.1; -; Genomic_DNA.
DR EMBL; LIAE01007064; PAV82333.1; -; Genomic_DNA.
DR EMBL; LIAE01007064; PAV82334.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2L833; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005230; F:extracellular ligand-gated monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0004888; F:transmembrane signaling receptor activity; IEA:InterPro.
DR CDD; cd18993; LGIC_ECD_GluCl; 1.
DR Gene3D; 2.70.170.10; Neurotransmitter-gated ion-channel ligand-binding domain; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR006202; Neur_chan_lig-bd.
DR InterPro; IPR036734; Neur_chan_lig-bd_sf.
DR InterPro; IPR006201; Neur_channel.
DR InterPro; IPR018000; Neurotransmitter_ion_chnl_CS.
DR PANTHER; PTHR18945:SF898; GLUTAMATE-GATED CHLORIDE CHANNEL; 1.
DR PANTHER; PTHR18945; NEUROTRANSMITTER GATED ION CHANNEL; 1.
DR Pfam; PF02931; Neur_chan_LBD; 1.
DR SUPFAM; SSF63712; Nicotinic receptor ligand binding domain-like; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00236; NEUROTR_ION_CHANNEL; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231}.
FT DOMAIN 834..930
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT REGION 62..140
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 362..425
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 534..564
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 581..679
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 62..93
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 362..419
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 581..604
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 605..620
FT /note="Basic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 621..648
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 649..665
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 942 AA; 110730 MW; C1AB04B12B8034E4 CRC64;
MLNWGWVKGG TIEAMSKLPK AAMDAANKNS TKPEEREAAD DKLYSLFRLP ADIMTQIAED
AGYIDEEKEE KEDKSTIKPW IVTKKKKYEE MDDHSENDDE EEYDTSGSFT QAKPHQKKTK
RRRKHKKEPK EEYDEDDGLI SLNSIFKQPT PASNQQQSTI SPIAPLPTFF PPMSFIQETT
TVSPPPPHMT PPTPRLAYQQ VVRDGKTYYE PVYILPPVAG MPLPTLSSVP SAQIPNVPTL
TDAHPPIGVP ILSKDTIIYT AAPTPPPSTT PSAFPTDTTS KPVVMVDSVS HSFSPPTFPP
PINLFQVAED ATRKFTGSSL FTTQQPPVSE QTEQTELYAE EVTVTRRPVQ FDGNKKYKST
LARIPVDKHY PDRHEEYQDN TETEDQEPVE RRSRHREEDL RNREDREMED DEEIPRKPKK
VLRNRKRKTV RRLKVPLDDD NGEYYPRRRM AENDPPVARR ASDRFVNEFN EFADDSEVDV
ELEKRKLHKR LLEGGMKRRR VHAAMTYNVD DEKDKRHERH GKYAKDKVND ELENFEDNSE
GKQMRRITIK RQRLRSSEER EEERRRKRAE LRRQLEEERR IEDERMEKQR EEEEEREREM
KRSRERRRLM KIRSRNRRRM QRKQMKEEEE DRRKGGEEDT EQEDGRAQWD EITTTTPANS
YPLRRRSSSR SRERIMRERK SRERNYVDLP VKKYKKKIPF QPSRAHCLNI RSFARQFGIL
DAIEFATTHC EFIENYYPEL QCSDTADYMR KCEEYYYSKF ISNLDFAEMQ ISIELTFREK
WTDPRLILGE ENDNFQIGGN DENYITLTDI SQIWKPDSFF QEEKESHLHS IDVPNVFARI
YPNGSITYSQ RISLVISCPM YLHDYPLDVQ RCPLSIASYG YTTEDITYVW KKNDPIQLYP
KLKSSLPNFK ISDISINNCS SITNTGTYSC IQLTIEFHRR SG
//
