ID A0A2A2LAL7_9BILA Unreviewed; 793 AA.
AC A0A2A2LAL7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=CBS domain-containing protein {ECO:0000259|Pfam:PF00571};
GN ORFNames=WR25_14494 {ECO:0000313|EMBL:PAV83229.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV83229.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV83229.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV83229.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV83229.1}.
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DR EMBL; LIAE01006979; PAV83229.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2LAL7; -.
DR STRING; 2018661.A0A2A2LAL7; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005247; F:voltage-gated chloride channel activity; IEA:InterPro.
DR Gene3D; 3.10.580.10; CBS-domain; 1.
DR Gene3D; 1.10.3080.10; Clc chloride channel; 2.
DR InterPro; IPR000644; CBS_dom.
DR InterPro; IPR046342; CBS_dom_sf.
DR InterPro; IPR014743; Cl-channel_core.
DR InterPro; IPR001807; Cl-channel_volt-gated.
DR PANTHER; PTHR45720; CHLORIDE CHANNEL PROTEIN 2; 1.
DR PANTHER; PTHR45720:SF10; CHLORIDE CHANNEL PROTEIN 2; 1.
DR Pfam; PF00571; CBS; 1.
DR Pfam; PF00654; Voltage_CLC; 2.
DR PRINTS; PR00762; CLCHANNEL.
DR SUPFAM; SSF54631; CBS-domain pair; 1.
DR SUPFAM; SSF81340; Clc chloride channel; 1.
PE 4: Predicted;
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 64..85
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 105..127
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 215..236
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 256..276
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 297..317
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 363..383
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 390..418
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 424..448
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 460..485
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 513..571
FT /note="CBS"
FT /evidence="ECO:0000259|Pfam:PF00571"
FT REGION 718..741
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 793 AA; 87995 MW; 9E32DAC91B2A8C6F CRC64;
MRSRIDLLNS IRKLRPTTST VAIVKHDANN SSADSIYKTS SIWAKLFAGP KRVWLRVGPT
FREWAFLIML GLTMAILSML TDIAIDELLI LERKLYRLCV DNDIVIVPYL VWTLIPVSMI
VISAGIARYF APQAIGSGIP EMKAIIGGVL LKGYLSIKTL IVKMIGICLT IGSGLPYGKE
GPFVHISSAV AHQLGKFMMH GDSGVYENES RDPDILAAGC AVGVACTFSS PVGVSVESHY
PTHFPTKNPF VPVELPIFAL MGIILGLAAS LFIFLFKHTI LFLRRNKLSI MLFKDYWFIY
PTLVSLIITS ITFPQGIGQY MGGDRRFSTF MEELFLNCTW TQNVSGSCDQ ILDNWHTDDT
SKMFISLGVF QIVFFVLTIL AGTMPISAGI FLPVMIMGAC FGRMVGEFIS ILAPYGLIAG
RPDIIIYPGI YSVVGAAAFC GAVTRTISVG VIMFELTGQI VHLLPVMIAI LIANAVVSLF
SLSIYDTIIE VRKLPFVPDI PASSTIYHQI TASHIMATPF IIAKDSTIGE VEDILMQLDL
KKPIKAFPLV ENKESMHLVG SIHTSHLIRL VKSVIGDDAR LKEAARRRQE EKLRIQRENK
RFSINRTQSL FQPVAKSNST DNVLNNLDVQ RALKDNERSH HTTYIHDMLK HTFNGAGKKK
KKKEVEIAII DMTSEEIHSL FSLLSLKRAY VTSKGKLVGT IGLDEFREAI EKAKSGIMPD
SKQNTQTPTK NKSIRIKEDK ENKNEDVDFI QPPLEIQRNV NTATVAADLS KLIEQGEERR
ASVQLENIAN VNG
//
