ID A0A2A2LCR3_9BILA Unreviewed; 1369 AA.
AC A0A2A2LCR3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=Sema domain-containing protein {ECO:0000259|PROSITE:PS51004};
GN ORFNames=WR25_06330 {ECO:0000313|EMBL:PAV83924.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV83924.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV83924.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV83924.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004251};
CC Single-pass type I membrane protein {ECO:0000256|ARBA:ARBA00004251}.
CC -!- SIMILARITY: Belongs to the plexin family.
CC {ECO:0000256|ARBA:ARBA00010297}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV83924.1}.
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DR EMBL; LIAE01006904; PAV83924.1; -; Genomic_DNA.
DR STRING; 2018661.A0A2A2LCR3; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 4.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF69; PLEXIN A, ISOFORM A; 1.
DR Pfam; PF08337; Plexin_cytopl; 2.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF01833; TIG; 3.
DR Pfam; PF18020; TIG_2; 1.
DR SMART; SM00429; IPT; 3.
DR SMART; SM00423; PSI; 2.
DR SUPFAM; SSF81296; E set domains; 3.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR PROSITE; PS51004; SEMA; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 773..795
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..146
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 1067..1090
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 799..841
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1369 AA; 152946 MW; 65AE17687BA5C664 CRC64;
MADVEEVFKS NIMDCYQGIV LKQLPWFKSS DQCKATRLQW KDVACGKDVN ANIGGGKPIQ
SKAVLVTEDA RFSALTVNTT RASTVAFVGT DDGRLLKVLL ESAVKAEVYA IEKVTSGEAI
LQDMEISGNG KHIFILTPTK VIKTATSSCD RNARTCFECL SARDPYCGWC MRSNICSEEE
SCEKVLPNTG SGWLDFQDTF CPVIKSVVPD KIQITTADYL NVTVDNIEEG QNQTRAAFLL
CPLDLLNSSP LSALLQTREG HSRRKGPSKC PHLVAPQSHL YVAVGERRNL SVKIQNLDPA
IMEEFRCEFR IGETKHEKPA LRSGEDTVVC GEMRFDQAGG DGLLPVAFDV VWMSSEAPKA
HVIDNTQKVA VEVYKCERLA SDCGTCITLD SAFYDCGWCK SQNSCSRQGE CSSQWLNGSH
LCANPKILDV TPKKGPFGGR TVLKIKGINL GRQPSDVQRA VQVANVPCEV VIEEYKPAKE
IVCVTGKATG AENKGPVVIR LKPDNYSYAA VSGFDFVYVQ PAVSRIQPSR GPRSGGTDVT
LYGTDLDAGS EVNVRFGDVD CRVIKRTASE LTCRTASSTT DGPLPLKIHF DGSHTRLPIS
INFEFSSPPR VHTIRPKYVF AAGGMQIDVS GQGFSLLQRP RMMLIGDRQR REIGPVCVVE
NDALMKSDRI DIYTNPSVES FPETRYYRAG DDSLTINGKD LNVAATERDF SVKIGGIDCP
LTSVANRVIT CIPPSVKPLL PSGTQPEVVV KIGNLNYQVG ILSYDSPGMA ASLMLLIAVF
IILMTCLFVC LFCVYRRKSS TQERKLRHLK LQMDNIEMKV ATECKQAFAE LQTSLDEYTA
ELPIGTAPAP FLTYREYCAR VLFPNNPHNH PVFQSVQVFP ERANAVETAL RELHKLLMNK
TFMLTMVRTM ESNKYFVAKD RVYVGSLLMV VLQQIEKGPQ DGLTMESRYS LSEEKLLRAT
FDYATLDIFV ETDIPGMGNA LVKAKRKCIE VKYRALLYSK RPGPSDMDLV WITGRNGGRI
ILQDIDETSR VEQGGWRKIN TLAHYNVHDR AIVALIEKQK PFYEPSFLSD HSSLQSRTSP
PMSRAWQSIS NSPSKEMDAN YKLYHLVKPT EHGPNEGQEK MVTEIYLTRL LMMKGTLQGF
INDLLCAIFS CHSPTSPFPA VIKYMFDFMD EQAALHGITD PEVSHAWKSN ALPLRFWVNL
IKNPHFLFDI SKPNTVEGCL SVVAQTLMDA CSTHDHQLTK DSPSSKLLFA KDMQEYKKWV
DSYYSEIRRL DKIKEEEMAS LLEKESRQHK NEFEVFSALN ELYKYIEQYK EPLMDALESN
EHALASRLNI RLQDMLALMS DGDQVTDYES STLGMGYNSS SRLMARERI
//
