ID A0A2A2LD54_9BILA Unreviewed; 731 AA.
AC A0A2A2LD54;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:PAV84074.1};
GN ORFNames=WR25_21174 {ECO:0000313|EMBL:PAV84074.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV84074.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV84074.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV84074.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004370}.
CC -!- SIMILARITY: Belongs to the protein kinase superfamily. CAMK Ser/Thr
CC protein kinase family. PKD subfamily. {ECO:0000256|ARBA:ARBA00008582}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV84074.1}.
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DR EMBL; LIAE01006889; PAV84074.1; -; Genomic_DNA.
DR EMBL; LIAE01006889; PAV84075.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2LD54; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004697; F:diacylglycerol-dependent serine/threonine kinase activity; IEA:UniProtKB-EC.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd20797; C1_CeDKF1-like_rpt1; 1.
DR CDD; cd20798; C1_CeDKF1-like_rpt2; 1.
DR CDD; cd01239; PH_PKD; 1.
DR Gene3D; 3.30.60.20; -; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR22968; PROTEIN KINASE C, MU; 1.
DR PANTHER; PTHR22968:SF15; SERINE_THREONINE-PROTEIN KINASE DKF-1; 1.
DR Pfam; PF00130; C1_1; 2.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00109; C1; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 2.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 2.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 93..143
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 177..227
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 278..405
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 428..687
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 467
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 731 AA; 82669 MW; 9300FF69579D24E2 CRC64;
MTFLHAAISP DYMQRIVLLK TCVFQVFESL RQRAMSIVEK KQPPGISNYE VHLFRHDYNS
PSVLNHVSSI AQLDNGCVIE IIVVDRNDTP TRLHVVLPES YMKPTFCDYC GELLAGLIKQ
GVKCQACGCN FHKKCWNAPR NNCAATQTPV LAPIRKDSNG IGHGIPFPIQ TPVSGLPHTL
AEHSYKSFTV CKVCDHLLVG LVKQGLKCRD CGVNVHRKCA IELPSNCTLA DHAISRMSIS
EMPDKEVEMA SASHSVPMNE NIPLFRLPGQ VTTRATSQPH VEGWMIHFVL SDPERRLKHY
WVLANNAIHM YNEYNEGLGV NPNRVYKILP LAEIIAITQH SGPPVLSRHP PHCFEIRTTN
NTVYCVGENL NYYSGEPVRK MPRSLSFRPP SNTQLWFQAL KESLQPPPSK SDPENAELAL
EFANLYQVLS EKTLGSGQFG TVYSAIQRHT GKEVAVKVIS KERFAKKGTA AESMRAEVLI
LHKMSHPGIV RLEFMCETKD KIFVVMEKMN GDMLEMILSQ ASGRLDSRVT RFLLVQILSA
LKYLHDQGIA HCDLKPENVL LSDMSTNFPQ TKICDFGYAR FIPESQFRKT IVGTPAYLPP
EVLQRRGYNK SLDMWSCGVI IYVTLSGTFP FNEGEEIADQ IQNAAFMFPT DPWSEVEPLA
TDLIQRLLKV NIEERLTIEQ CLAHPWLKSE QLYRDLRSLE VRLNLPRYLT TEEDDERYAQ
LLQQQGLIPV Q
//
