ID   A0A2A2LEC6_9BILA        Unreviewed;      1030 AA.
AC   A0A2A2LEC6;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 12.
DE   RecName: Full=SSD domain-containing protein {ECO:0000259|PROSITE:PS50156};
GN   ORFNames=WR25_22041 {ECO:0000313|EMBL:PAV84529.1};
OS   Diploscapter pachys.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX   NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV84529.1, ECO:0000313|Proteomes:UP000218231};
RN   [1] {ECO:0000313|EMBL:PAV84529.1, ECO:0000313|Proteomes:UP000218231}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PF1309 {ECO:0000313|EMBL:PAV84529.1};
RA   Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA   Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT   "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL   Curr. Biol. 0:0-0(2017).
CC   -!- SIMILARITY: Belongs to the patched family.
CC       {ECO:0000256|ARBA:ARBA00005585}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAV84529.1}.
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DR   EMBL; LIAE01006839; PAV84529.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A2LEC6; -.
DR   STRING; 2018661.A0A2A2LEC6; -.
DR   Proteomes; UP000218231; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR003392; Ptc/Disp.
DR   InterPro; IPR000731; SSD.
DR   PANTHER; PTHR10796; PATCHED-RELATED; 1.
DR   PANTHER; PTHR10796:SF181; SSD DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF02460; Patched; 1.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   PROSITE; PS50156; SSD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        25..44
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        296..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        323..346
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        353..376
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        427..450
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        520..543
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        722..746
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        753..773
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        779..797
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        818..843
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        855..879
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          293..450
FT                   /note="SSD"
FT                   /evidence="ECO:0000259|PROSITE:PS50156"
FT   REGION          955..1030
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        955..991
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1012..1030
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1030 AA;  114964 MW;  6B5A0D5C063E902A CRC64;
     MVRFDCVEKR FAKLFGNYST IVVRYPLPFF ILPILLSCGL GIGLTRHKQA FMKDELELYT
     PTDAQARREL KQLDTLFHIN DSDPFYATRR YDIRRSGYII VTQRDDEDIL NPLVMHAAMQ
     LWSVVQALTV EDQEDRHINY PSICVKFPIP PEFSKVLHSL FSPNITTPDE ICVSNPLVEM
     FKLLLVSDRS FLNRSIDEMT LGQISDAVQF DSGGMRHLLG GITLDSEKRI AGAKAIMLPY
     ALRHSSQVED WLAEKWELRL ADFLLQYDSP VIRASWWTYE TLAAESARDR NTLIRMLIPC
     FCAVSIYTVI CCCVLSWRRS RPWLAIGGVI SAAMACESAV GLLLLLGYGM TSVAYSMPFI
     VFSVGVDNVF ILLSAWRATP TNESMERRMH ETFADAAVSI TVTSLTDLIS FAVGCATPFP
     SVQMFCMYAV VAVIFTYIYQ LTFFAAVMVY TCRREINNRN CVTFTKLEKD KGRHSFEDSL
     QPEELGGNSW TLEKKVSVGD RSFEKNHVLA RFFRTTYADV LLNPLFRIII LALFAAYLGI
     SIWGCTKVKL GLEPNDLLPD NSYGKRSLQM AEKYFSDYGS YLHVWMYNLS TTDIGNRRIW
     SVLEKEIELY EHTEFTGSSD SWLRTFLSFV KQSGLLITTD NFVYILKNVF LSQPQFSKYA
     RDVVLDTSGT LLDASRIPVQ LRHVGSTNQS RAMHLFRRLA ETSELPTGVY ADFFQFAEQY
     NAVLPGTLSS IACAGAAVIA VSLILIPEPV ASLWVSFSIV SINIGILGLM TFWSVRLDFI
     SMVTIVMSIG FCVDFAAHIA YNFAKGKDIT ADERMRNALY AVGAPILMSA SSTILGVSFM
     ATAESYVFRS FLKTIILVVV LGVLHGLVIL PVLLTLFYCG DSAASKKNAE RLKSVHENLA
     KKYPVLSAIS SSSAAVNGNG PPPSFMSGSL AAELYSLPPS TCEYSLSSLE YSRSAGSSYS
     SRPPDYEETQ QQTGGGMPIG MGQTQQLHNS GGMLFPMRAK LKPKSKRSGS GSEESESPPS
     LDYFYHTPSG
//