ID A0A2A2LFU5_9BILA Unreviewed; 794 AA.
AC A0A2A2LFU5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=WR25_04471 {ECO:0000313|EMBL:PAV85020.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV85020.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV85020.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV85020.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP = 3',5'-cyclic GMP + diphosphate; Xref=Rhea:RHEA:13665,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:37565, ChEBI:CHEBI:57746; EC=4.6.1.2;
CC Evidence={ECO:0000256|ARBA:ARBA00001436};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV85020.1}.
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DR EMBL; LIAE01006806; PAV85020.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2LFU5; -.
DR STRING; 2018661.A0A2A2LFU5; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR InterPro; IPR028082; Peripla_BP_I.
DR InterPro; IPR000719; Prot_kinase_dom.
DR PANTHER; PTHR11920; GUANYLYL CYCLASE; 1.
DR PANTHER; PTHR11920:SF355; RECEPTOR-TYPE GUANYLATE CYCLASE GCY-10-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF00069; Pkinase; 1.
DR SMART; SM00044; CYCc; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW cGMP biosynthesis {ECO:0000256|ARBA:ARBA00023293};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 217..497
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT DOMAIN 568..698
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
FT REGION 752..794
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 752..772
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 773..794
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 794 AA; 89423 MW; 43C7CDCFDAC070DE CRC64;
MLNTQENPVL NLQKYMSINE EADNVNELID NVAKDIEVTS QVLVIGSDFV DLYGVLQKLD
LHKISTRNFI TVLVAPTGVL KITANDALRR YLNSAGVYVL APIINISENF TIKISTSINA
TGPILDLDQI EEPALLYSAC YAFCVARKKY DSDTVDNYYK TLAGQEYTND LGTFKFDQNG
VVLRDYQFMY LRNDKRGNDT VIMTVKAQYA ETCGPHYQCF TVRGPGGKTT KPSSHETLTS
KRRTITSYAL MGTVKAEFLF YRQFKRIRWT KPELRYLTEL KALNHDNITK FIGLSCNDSA
DVYILYGLVE RATLEDFIYD SDFSLDFTFK SAFARDILRG LQYIHKSSIV AHGMLSVQTC
MIDANWVLKL TNFGVSSLIH NFMTDGTLQC TTSIALEELL REIAHCATAS VPRGTQKGDI
YSLGMVLYQM VYRMQPFPKS SSAQELIVGI IDRRMKPERL EASAEENKLV DCIMLCFNEP
EKRPKAREIA NAVSTVYTAA KGNLVDQMIR MNEKYALNLE KLVKERTDLL VAAQEQTDRL
LNEILPKSVA QVLKLGGVIP PRSYDSATVL FAQLCDFPLL VGKSGPDDVI NFLNDVFDKF
DNIIRKHDAY KVETTGETYM VVSGVPTENE GQHVFEIAEI SLEIRETAMN YVVEHCPSFK
VRTRIGFHAG PIAAGVIGIR SPRYCLFGDT VNFASRMQSN CPPSQIQTSE VTANILMKSE
EYSLVQRGIV HVKGKGNVNC YWLNEHIHDL SNEEPEGNIH KSDNENRPKT TQQKLEDQNA
TPLPKSLIQN NNQS
//