ID A0A2A2LJ37_9BILA Unreviewed; 576 AA.
AC A0A2A2LJ37;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Carboxylic ester hydrolase {ECO:0000256|RuleBase:RU361235};
DE EC=3.1.1.- {ECO:0000256|RuleBase:RU361235};
GN ORFNames=WR25_24272 {ECO:0000313|EMBL:PAV86263.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV86263.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV86263.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV86263.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SIMILARITY: Belongs to the type-B carboxylesterase/lipase family.
CC {ECO:0000256|ARBA:ARBA00005964, ECO:0000256|RuleBase:RU361235}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV86263.1}.
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DR EMBL; LIAE01006688; PAV86263.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2LJ37; -.
DR STRING; 2018661.A0A2A2LJ37; -.
DR ESTHER; 9bila-a0a2a2lj37; ACHE.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0003990; F:acetylcholinesterase activity; IEA:UniProtKB-EC.
DR Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR InterPro; IPR029058; AB_hydrolase.
DR InterPro; IPR002018; CarbesteraseB.
DR InterPro; IPR019826; Carboxylesterase_B_AS.
DR InterPro; IPR000997; Cholinesterase.
DR PANTHER; PTHR43918; ACETYLCHOLINESTERASE; 1.
DR PANTHER; PTHR43918:SF9; CARBOXYLIC ESTER HYDROLASE; 1.
DR Pfam; PF00135; COesterase; 2.
DR PRINTS; PR00878; CHOLNESTRASE.
DR SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
DR PROSITE; PS00122; CARBOXYLESTERASE_B_1; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361235};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Serine esterase {ECO:0000256|ARBA:ARBA00022487};
KW Signal {ECO:0000256|RuleBase:RU361235}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU361235"
FT CHAIN 19..576
FT /note="Carboxylic ester hydrolase"
FT /evidence="ECO:0000256|RuleBase:RU361235"
FT /id="PRO_5011821451"
FT DOMAIN 33..239
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT DOMAIN 240..544
FT /note="Carboxylesterase type B"
FT /evidence="ECO:0000259|Pfam:PF00135"
FT ACT_SITE 222
FT /note="Acyl-ester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
FT ACT_SITE 328
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
FT ACT_SITE 457
FT /note="Charge relay system"
FT /evidence="ECO:0000256|PIRSR:PIRSR600997-1"
SQ SEQUENCE 576 AA; 66287 MW; 8528558CC97B5D9F CRC64;
MVYDFLRILS LTFQVVSATT PFTIDRSRVP VDVSTRSGVF RGEESFHLSV RIRTFLSLPF
AQPPLGRLRF LPPKPLHHFD GVFDTREPSP ACYQVRDEYN RSFWGSEMWN ANTQISENCL
FMSIWAPADV VNVPVMVWLF GGGFYSGSPS LQLYDGKTLA AYSNVIVINI NYRLGPFGFL
YLPPAVPGNM GLLDQQLALH WIKNNIAYFG GNPTRITLFG HSAGAASIVG HLIAPASKRV
EEKSKQLARE LGCYGDDNHQ IVNCIRNLPP HFISAYIWHM DLEFIEFPFG IISRDVNFFR
YKDAFTALRK QDFSNPDVNF LIGLNKDEGN SWGIYYLADY FDKIEHPVLT RENMTKATDI
AFAALPSFIR RAAQFVYEDV GGKCVPNGVP SKYLAKQMSK MLGDYFFSCD SLWLADQIAS
QNRSNETTKQ NKNNVFIYYF AQHSSLNPWP KWTESMHGYE IEFVFGAPLK NSSTGYRRRE
VILAKKMMQY WSSFASDGYP TLLNPKRTEV WPQFTNDNRR WMQLKSGSNT RSIMEMKRKE
CAVWRRAKDL QYDEYREFLA KILIRLKYHG PAKRDL
//
