ID A0A2A2LKK6_9BILA Unreviewed; 1809 AA.
AC A0A2A2LKK6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE RecName: Full=Myosin motor domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_17126 {ECO:0000313|EMBL:PAV86761.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV86761.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV86761.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV86761.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SUBCELLULAR LOCATION: Cytoplasm, myofibril
CC {ECO:0000256|ARBA:ARBA00004657}.
CC -!- SIMILARITY: Belongs to the TRAFAC class myosin-kinesin ATPase
CC superfamily. Myosin family. {ECO:0000256|ARBA:ARBA00008314,
CC ECO:0000256|PROSITE-ProRule:PRU00782}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV86761.1}.
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DR EMBL; LIAE01006637; PAV86761.1; -; Genomic_DNA.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0016459; C:myosin complex; IEA:UniProtKB-KW.
DR GO; GO:0032982; C:myosin filament; IEA:UniProtKB-KW.
DR GO; GO:0030017; C:sarcomere; IEA:UniProt.
DR GO; GO:0051015; F:actin filament binding; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003774; F:cytoskeletal motor activity; IEA:UniProtKB-UniRule.
DR CDD; cd01377; MYSc_class_II; 1.
DR Gene3D; 1.10.10.820; -; 1.
DR Gene3D; 1.20.5.340; -; 5.
DR Gene3D; 1.20.5.370; -; 3.
DR Gene3D; 1.20.58.530; -; 1.
DR Gene3D; 6.20.240.20; -; 1.
DR Gene3D; 3.40.850.10; Kinesin motor domain; 1.
DR Gene3D; 2.30.30.360; Myosin S1 fragment, N-terminal; 1.
DR Gene3D; 1.20.120.720; Myosin VI head, motor domain, U50 subdomain; 1.
DR Gene3D; 4.10.270.10; Myosin, subunit A; 1.
DR InterPro; IPR000048; IQ_motif_EF-hand-BS.
DR InterPro; IPR036961; Kinesin_motor_dom_sf.
DR InterPro; IPR001609; Myosin_head_motor_dom.
DR InterPro; IPR004009; Myosin_N.
DR InterPro; IPR008989; Myosin_S1_N.
DR InterPro; IPR002928; Myosin_tail.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014751; XRCC4-like_C.
DR PANTHER; PTHR45615:SF40; MYOSIN HEAVY CHAIN, MUSCLE-RELATED; 1.
DR PANTHER; PTHR45615; MYOSIN HEAVY CHAIN, NON-MUSCLE; 1.
DR Pfam; PF00063; Myosin_head; 1.
DR Pfam; PF02736; Myosin_N; 1.
DR Pfam; PF01576; Myosin_tail_1; 2.
DR PRINTS; PR00193; MYOSINHEAVY.
DR SMART; SM00242; MYSc; 1.
DR SUPFAM; SSF90257; Myosin rod fragments; 5.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS50096; IQ; 1.
DR PROSITE; PS51456; MYOSIN_MOTOR; 1.
DR PROSITE; PS51844; SH3_LIKE; 1.
PE 3: Inferred from homology;
KW Actin-binding {ECO:0000256|ARBA:ARBA00023203, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Methylation {ECO:0000256|ARBA:ARBA00022481};
KW Motor protein {ECO:0000256|ARBA:ARBA00023175, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Muscle protein {ECO:0000256|ARBA:ARBA00023179};
KW Myosin {ECO:0000256|ARBA:ARBA00023123, ECO:0000256|PROSITE-
KW ProRule:PRU00782};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00782}; Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Thick filament {ECO:0000256|ARBA:ARBA00022433}.
FT DOMAIN 26..75
FT /note="Myosin N-terminal SH3-like"
FT /evidence="ECO:0000259|PROSITE:PS51844"
FT DOMAIN 79..786
FT /note="Myosin motor"
FT /evidence="ECO:0000259|PROSITE:PS51456"
FT REGION 661..683
FT /note="Actin-binding"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
FT REGION 868..889
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 930..953
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1039..1062
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1603..1625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1715..1736
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1771..1792
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 172..179
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00782"
SQ SEQUENCE 1809 AA; 208963 MW; 7711838908065BF1 CRC64;
METDAGWQFL RQSQEQMLAS MTKKFDSKKN IWIADPEDGF VAAEIKSSKG DTHVVVTAKG
VEKTIKKDDA QQMNPPKFEK TEDMANLTFL NDASVLNNLR QRYYSMMIYT YSGLFCVVIN
PYKRLPIYTE SVAKMYLGKR RNEMPPHLFA VSDEAYRNMV NDHENQSMLI TGESGAGKTE
NTKKVISYFA MVGATQTKKV DEKSDKKKNA TLEDQIVQTN PVLEAFGNAK TVRNNNSSRF
GKFIRIHFNH AGKLAGGDIE HYLLEKSRVI KQAPGERCYH IFYQIYSDAI KGLKDRLFLT
RPIKDYHFVA QAEVTIEGVD DKEEMMLTDE AFDIMKFDQR EKDELFAITA GIMHMGELKF
KQRPREEQAE LENGKEGELA CKLYQVEPEK FIGALLKPRV KVGAEWVNKG QNLEQVNWAV
GALAKALYAR MFAWLIQRCN KTLDAQDLPR DFFIGVLDIA GFEIFDLNSF EQLWINFVNE
RLQQFFNHHM FVLEQEEYQR EGIKWEFIDF GLDLQACIEL IEKPLGIISM LDEECIVPKA
TDLTLAQKLS DQHLGKHPNF QKPKPPKGKQ AEAHLAIVHY AGTVRYNVLS WLEKNKDPLN
DTAVTILKAN AGNALMDALW SNYDTQEDIA NQAKEGKTVP GKKKGKSASF MTVSMMYRES
LNKLMNMLHQ THPHFIRCII PNEQKKAGVI EATLVLNQLT CNGVLEGIRI CRKGFPNRMP
YLDFKQRYAI LAADAVKTGK DVKDAGEKIV GQLEKKGQLK VEEFQCGLTK VFFKAGVLAR
LEELRDEALS IIMTKFQCAA RGYLALCEYK RRKEQRVGLL IVQRNVRAWC TLRNWTWFKL
FGCVKPMIKG NKKDEEFEAL EKKYKELEEE KNKEEKRRKE LESETDRMNA EKQALLAQLE
QERDANAETE ERSAKLLAQK ADLEKQNADL NDQLADQEDK NSTLSKAKKK VEQDCENLKK
NVADLETTIK KQESEKQSKD HQIRSLQDEI AAQDEVINKI NKEKKHQEEV NRKLLEDIQA
EEDKVNHLNK LKTKLESSLD ELEDQIEREK RGRQDLEKQK RKVEGELKLA QETIEELNRQ
RHEQEQALKK KDAEIHNLQS RLEDEQSLVA KLQKHIKELL AKIQELEEEL EAERQSRAKA
EKARNEMQLE LEELGDRLDE AGAKLEKEKA ALQREVDELQ QTLDVDAKQR QNCERLAKQL
ESQLTDMTLK SDEQARLIQE LTMGKSKMHN ENSDLNRQLE DAESQLAALN RIKQQQHSQL
EELKRQLEQE SRERSTLHSQ AANYQLECEQ LREQLEEEQD AKTELQRQVS KANAEAQQWR
AKFEGEGVNR SEELEEARRR LTHKVQEMQE HLEQANQKIA TLDKTRQRLQ HELEDAQVDA
DRANQIATSL EKKQKGFDKV IDEWKRKCEA LVAEVEQSQR ETRAAATETF RLRNQLEESH
EQTEAVKREN RALAQELKDI ADQLGEGGKS VHDLQKLRRK LEIEKEELQQ ALDDAEAALE
GEEAKVLRAQ VEVSQIRSEI EKRLQEKEEE FESTRKNHAR AIESMQATLE NETRGKAELL
RMKKKLESDI NELEIALDHA NKANVESQRN LKRYQETVRE LQTQAEDEAR HRDEAREHAA
TAERRAQALQ QEKEDMAVGF EQAERSRRQA ELLAAEHKEA LNDFVAQNMG LTSIKRKLES
ELQQLHSEIS DALNEAKNSE DRAKKCAMDA AKVSDELRAE QEHSANLERA KKANESHIKD
LQTRLDEAEA NQAKGGKKAI AKLDARVHDL ESELDSEQRR HTETAKNLRN KDRRCRELQF
QVAKIHQKR
//
