ID A0A2A2LP52_9BILA Unreviewed; 590 AA.
AC A0A2A2LP52;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=RING-type domain-containing protein {ECO:0000259|PROSITE:PS50089};
GN ORFNames=WR25_20262 {ECO:0000313|EMBL:PAV87996.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV87996.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV87996.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV87996.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- SIMILARITY: Belongs to the RAPsyn family.
CC {ECO:0000256|ARBA:ARBA00007295}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV87996.1}.
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DR EMBL; LIAE01006535; PAV87996.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2LP52; -.
DR STRING; 2018661.A0A2A2LP52; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR GO; GO:0045202; C:synapse; IEA:InterPro.
DR GO; GO:0033130; F:acetylcholine receptor binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0043495; F:protein-membrane adaptor activity; IEA:InterPro.
DR GO; GO:0007268; P:chemical synaptic transmission; IEA:InterPro.
DR CDD; cd16478; RING-H2_Rapsyn; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR001237; Postsynaptic.
DR InterPro; IPR019568; Rapsyn_myristoylation/link_N.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR001965; Znf_PHD.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR46574; 43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE; 1.
DR PANTHER; PTHR46574:SF1; 43 KDA RECEPTOR-ASSOCIATED PROTEIN OF THE SYNAPSE; 1.
DR Pfam; PF10579; Rapsyn_N; 1.
DR PRINTS; PR00217; POSTSYNAPTIC.
DR SMART; SM00249; PHD; 1.
DR SMART; SM00184; RING; 1.
DR SMART; SM00028; TPR; 5.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW TPR repeat {ECO:0000256|ARBA:ARBA00022803};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 398..442
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT REGION 1..32
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 469..488
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 521..555
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 521..543
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 590 AA; 65592 MW; 045E35C1FF965249 CRC64;
MGVLARQRLS DQRKRKQLLG NHTPMGQRAA KQNMQAGVRL YHQRHHATAI NKWRNALNKL
NNAEDRFITL GYLAQAFCDA ADYEGMLQYA LQQMELANDK KDDYMKSEAF LNLAKAYEKL
ADFSKALSYG KASLQHPSMD SRTPGYAHFT MAMAHLGFSQ FQNSLEEFEA SMNIANETGD
RLLELQICVG LGSLFTLLRD ITKALIFLRN ALAIVQSVSV EDVHAKYRCL ILYHLSVALR
IKGNLVDAKD ACDEATQLAI EIGNRSLEGR CMCSLADIYR ELGESEAKET ITKSWARYEE
AFRMMRAASD RMGELIVLSR MAKSASESRS HYTGQCECQA IQLNKKCLEI SKSLGCKYVM
LKCHLRLADL YSQLNDDDSE EAARTAVSQL TQQMQLFCNF CGQRFATKDA SLQALRCSHI
FHERCLHTFL LEREDQTCPK CKCRAVATTG ISDAISMRTP SICSTADLQS PSTSAFPKGP
PGGVRTPLVD VASSSQDKSR IARYRWETEE AINRLDSAID KMTSSQSQPQ PEAGPSTSHA
HCNNKPAPPI RKPSCSTNCL PPSSLAVVMA QPIPENGPLV ITRAATVTDV
//
