ID A0A2A2LTF2_9BILA Unreviewed; 1066 AA.
AC A0A2A2LTF2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=EGF-like domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_06167 {ECO:0000313|EMBL:PAV89511.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV89511.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV89511.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV89511.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV89511.1}.
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DR EMBL; LIAE01006449; PAV89511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2LTF2; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0007160; P:cell-matrix adhesion; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 5.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 2.170.300.10; Tie2 ligand-binding domain superfamily; 2.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR024731; EGF_dom.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR003886; NIDO_dom.
DR PANTHER; PTHR24050:SF27; FIBULIN-1; 1.
DR PANTHER; PTHR24050; PA14 DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF12947; EGF_3; 1.
DR Pfam; PF07645; EGF_CA; 5.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF06119; NIDO; 2.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 7.
DR SMART; SM00539; NIDO; 2.
DR SUPFAM; SSF57196; EGF/Laminin; 1.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR PROSITE; PS00010; ASX_HYDROXYL; 5.
DR PROSITE; PS01186; EGF_2; 4.
DR PROSITE; PS50026; EGF_3; 6.
DR PROSITE; PS01187; EGF_CA; 4.
DR PROSITE; PS51220; NIDO; 1.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 990..1015
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 1..131
FT /note="NIDO"
FT /evidence="ECO:0000259|PROSITE:PS51220"
FT DOMAIN 375..415
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 416..459
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 460..497
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 502..538
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 805..845
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 846..887
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT REGION 260..320
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 941..978
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 274..320
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 956..978
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 427..444
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1066 AA; 116473 MW; 18AA2B2FB979CA3C CRC64;
MSSEGGKVYY RESTDIDMLN LAHNEVNIQY RYGSKFQVKS VLLITWEDVR STNNPMAEGN
TFQLALIIGD TMTFAHFVYS KLNINHNAVA GFSAFNHTYS LPDSGTSDAI TLAEKSDIGI
PGEWLMQIDS EQVYLCGYGF KGLECIEACE ASQWFNDCSK SCHCDGGDAC DQETGRCPSG
KCSPGWENEP TCDKDIDECQ ASVSPCPKEQ PDCLNSPGSF LCLCFEFDEQ KKTCKGSPQL
IGSPSPIPVD VVPMHPSFQS HATTRKHVAK KPQRFSSTTK STLPPTTTTT TTTPTTTTTT
TTASTSTATT TTTELQTSPS ASLRQIEVAP SQITFAPPTS ITTSVCTNCD RHAICHNRRC
VCNEGWQGDG TRCYDVDECT KDPKVCGAHA SCVNTEGGYD CVCDGGFMLS NNHCTDIDEC
SNDEKICGES RGIECVNKVG SFECRCRDGY EGSMETGCSD INECVRPEAC GPNARCANTA
GGYECECLTG FERLAPEAFC TDIDECAVSP CHHAAICTNI KGSYTCTCPQ GFIGDGMECA
ETILYPISND SFILPRQWNA WAAINLPTEI KIFGRRYSKA YLSSNGIVSF DMPLSGVVED
PKLVNSSAIF ALHSQHDYSR EGLVAYTYIN ESDPTASPLL KRATLGARDV FHIPNFDTTR
LHIFTFDGMR QAGSENVNSF QIVLAESRTG ETLASLIYEK AGSKGPITGI SYPHSFFFLP
NDQLSSMSNV AHPGLWMYRI DANLVPCPAG RHETPICNME CASGHWGFDC INDCHCQRGE
ACDKQNGTCQ NGCDAGWQGD SCNDDIDECA ANLVQCGLGA VCENKIGSFE CKCDRGYLLL
NNVCQPVERC VSRYGLPCSE HASCEEKPDG PTCICHAGFE GSGFQCELKR IPNDLASSGR
NVLLAPSVPK TDGTIPFNIP NISQWPTTEN KPTLATAASM VPPHYTAPPI KPLDTKSSET
KNEKNDDAKK LDDESLKEGD KDAQADASTM FFVIAPIVLC SIWFVLVLVV IALCWKHRTQ
RRRFDTQKQM ENIWAQPVTS SHRPSLSIHS FPQNSAPSRI RNFEGY
//
