ID A0A2A2LXK9_9BILA Unreviewed; 596 AA.
AC A0A2A2LXK9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 13-SEP-2023, entry version 19.
DE RecName: Full=DH domain-containing protein {ECO:0008006|Google:ProtNLM};
GN ORFNames=WR25_19913 {ECO:0000313|EMBL:PAV90964.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV90964.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV90964.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV90964.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV90964.1}.
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DR EMBL; LIAE01006340; PAV90964.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2LXK9; -.
DR STRING; 2018661.A0A2A2LXK9; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR45834:SF3; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 3, ISOFORM L; 1.
DR PANTHER; PTHR45834; RHO GUANINE NUCLEOTIDE EXCHANGE FACTOR 9-RELATED; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF07653; SH3_2; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 172..232
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 254..438
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 469..577
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 107..168
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 596 AA; 67779 MW; 8119DD291DA87A90 CRC64;
MHSTPISNSF YCRRRLSLIE ALNNSIQEDL CCPNFASSAL NPLQALPMAT CSHSTPAPSA
RERIFSVRQI LSQNQDLLDR GRLSMRRSGA RGREESYHPI QQYFSSSASS HQFLRSNPQK
RSRRQPNNNT NNTNASQESE EEQDGSSWNS ACRSSLHSTS SSSGSRSSAI DSSMQLAEAL
FDHIALMSDE LPFATGDIIY VLDSCSQSAL WYGSCNGNEG WFPSSHCKML TQSPNSQSTQ
SNREEIFTTE IRKRRANVVE ELMRSERDYV RLLEDIVQGF LEQTRRRTDL FTPQRIRNIF
GNIQSIYVIH SKLLRDLEMA YDQMQPEMTN VGAAFLRNKH SFNIYTDYCN NRSVSVAELN
SLSRQPIYAQ FFEACRLLRG LPNLSLEGFL LTPIQRLCRY PLQLSELLKA TPSSHEDLMP
LEASEKTMRS VATLVNETKR RVENLQDIIR LQKRMQGFKG PDVVENNSTL LRTGDVYCRV
MADGQVQWGK QVLLFLFDQS IVLCKKDVLR DDKFIFKDRL SLDLFSIVDV KDGKESNFNV
NVKHSLLLTG QDRLYLISCG NKKSKQCWLT ALRSRSAQNP ATAEERRLAM ATLTSA
//
