ID   A0A2A2LYB9_9BILA        Unreviewed;      1797 AA.
AC   A0A2A2LYB9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=VWFA domain-containing protein {ECO:0000259|PROSITE:PS50234};
GN   ORFNames=WR25_09194 {ECO:0000313|EMBL:PAV91234.1};
OS   Diploscapter pachys.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX   NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV91234.1, ECO:0000313|Proteomes:UP000218231};
RN   [1] {ECO:0000313|EMBL:PAV91234.1, ECO:0000313|Proteomes:UP000218231}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PF1309 {ECO:0000313|EMBL:PAV91234.1};
RA   Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA   Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT   "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL   Curr. Biol. 0:0-0(2017).
CC   -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC       matrix {ECO:0000256|ARBA:ARBA00004498}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAV91234.1}.
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DR   EMBL; LIAE01006329; PAV91231.1; -; Genomic_DNA.
DR   EMBL; LIAE01006329; PAV91233.1; -; Genomic_DNA.
DR   EMBL; LIAE01006329; PAV91234.1; -; Genomic_DNA.
DR   EMBL; LIAE01006329; PAV91235.1; -; Genomic_DNA.
DR   Proteomes; UP000218231; Unassembled WGS sequence.
DR   CDD; cd00198; vWFA; 1.
DR   CDD; cd01450; vWFA_subfamily_ECM; 3.
DR   Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 6.
DR   InterPro; IPR002035; VWF_A.
DR   InterPro; IPR036465; vWFA_dom_sf.
DR   PANTHER; PTHR22588; UNCHARACTERIZED; 1.
DR   PANTHER; PTHR22588:SF3; VWFA DOMAIN-CONTAINING PROTEIN; 1.
DR   Pfam; PF00092; VWA; 6.
DR   SMART; SM00327; VWA; 6.
DR   SUPFAM; SSF53300; vWA-like; 6.
DR   PROSITE; PS50234; VWFA; 6.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000218231}.
FT   DOMAIN          159..333
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          488..663
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          795..969
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          1004..1175
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          1256..1429
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   DOMAIN          1464..1645
FT                   /note="VWFA"
FT                   /evidence="ECO:0000259|PROSITE:PS50234"
FT   REGION          768..787
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1662..1692
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1707..1751
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1662..1681
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        1726..1742
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1797 AA;  200336 MW;  D21F940A829719E0 CRC64;
     MSLRPHLSLD TSVAKALQIG AQQLSYFDTP YNKRIIVLSH DGVTSDLVGE TLEAVSIVQN
     LQISVLVVSG NPLANDKALT GYAGQRERVY HQPNDAALFL EELDKIILCD VPSQKISHSP
     SSHRISGVKT QTIDDKGEHE KKKSKVFELW QKCDRDLVDL MLVLDTSGSV RSIFELQRRF
     AINILDQFPS KSYKNGRIQV SVVRFSNNPV VEVKFKIGQH KKEILQTIRN LTFTGSSTRI
     AAALDTALVE MEKEKRPAAK QVLVLISDGH GQEYWNVVQQ TGANLHETDY EIFAVSTGRS
     YNEAELLIYA GDVSRLFVGP RYDSFIPVFT PYLYGCIRED KFAVNQKLPE IEKPSEVRVR
     ADSNTLPADE FLNQEKIEPA ARRVNFVDSK AESLISSKVH TTTSQSVTHP FFTTTHHTTT
     PTQIRSLNNL GNVNELNKPI DKQQQQLMKL IEKADREKQQ LVTTTTSKPE FGREGSLAKD
     WNGSCEVDLV LIIDRSQSVE EEFEREVITA KRVIEQFPRS LYANGTIRVG IVSFAWDAKV
     ELDLKLNDPD EIIQRLSGIY HTGGTTSTVA GATAAIKSMY PYRRPNARLL ILLFSDGYSQ
     DYWRDLLSTA EELQRPAGSA IIAYTASPTF SQIELTAWTG GGPEAVYTKE QDIGFILKVQ
     REVWRYCAGD KDKSVMVHSE LSTSMKDRVK LPLPNVAPVR HEAPSTLPPV VKLETQFQVI
     TPDSRLVKEK MAKMKATTTT TFAPKIQKTP IEIKREESDN NLENLEKLDN VSPVDGSGEG
     SGEIDEDVDG PCKMDLMLII DISTSVQSDF EMDMQYAIDL TDRLPAKDFE DQVRMGIVTF
     NMTAQLVHSL ADRNSKSALL DLLLAQNNTG GGSTSLANGV SLALEDLAKN RRKNAKQVAV
     IISDGNSRDE WQNVLKAANG LKDQKIIVYA VSAARNSTKR ELEMYTGNKE RVYMEQQTGK
     FLTDVTKEFA LCTEKPRSKL IIGDQLLSRK AHQEESDNCD GLIDLILLID KSKEEYEQFA
     ADHQIAMDLI NSLPKELFNK RLAVSLIEYG SHAVGRLALG IYKQPYIIES LQRIHNKRAE
     ASLSAAVNEA LRQMGKRRIH SKLYVVIISD GSTSDDWQEA QTHASKLLKT DAKVFAATNA
     EKFYMDELKE YTGNSSRVYT LNKTRHFVEE VGNEILGCKN LKLERLVNVE KQTPSQLTTD
     QLLPITTSIS TTSLPKLDVI EKLDAREKVK RVDDLNSVIV EAPVANIQNC SRNKIDLQII
     LDASSSREEV FEAQRELALN LIEKLPISAS GTHVAVGINS FTSTPVLRQT LGLGRDKNIV
     RSVIEDIEYK GGSTLTAQAV ELSLEDLERG KRDDATQVVV LMNDGFSQDH WEKVVRASDK
     LRNSSAEIFG VALGGDIDLR ELNRYIPRKD RLYRDTDTDK FIHDITELLG SHDACVENTI
     KEMENPVEMA AKKMMEKCEA DDLDLMIVFD NSDKTKNMSN PAINSNRYLL LDVLGSLSKL
     MGNRPARVRI SVVAVAEKGK PKVNLDFTEI SERDKLFAEI ESIKAINGKA SYSDAVMVGL
     NHLGKAGSKK ARHGLLIVGP GQSDDPYKKT LSAASRIRHM PNFTCLAVDA SSNTNSRYLT
     TLTGSPNTVF DYDGNIEFAQ KLHQIAFMSN TAECKNNVPT LNEKSQTKKP VKATTAHGNT
     SAGHKGKGKD ADLPEEILRH RGARKFDNSD GVHEQTYMTP PADYTVKSEK GHRGDKPKQR
     DVPSYRPPVV KNGELQDDIA RNIDDEKQLV DKLDAELGKA IETVAVKTTE SKAEHSE
//