ID A0A2A2LYQ2_9BILA Unreviewed; 971 AA.
AC A0A2A2LYQ2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE RecName: Full=Phosphoinositide phospholipase C {ECO:0000256|ARBA:ARBA00012368, ECO:0000256|RuleBase:RU361133};
DE EC=3.1.4.11 {ECO:0000256|ARBA:ARBA00012368, ECO:0000256|RuleBase:RU361133};
GN ORFNames=WR25_12629 {ECO:0000313|EMBL:PAV91381.1};
OS Diploscapter pachys.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV91381.1, ECO:0000313|Proteomes:UP000218231};
RN [1] {ECO:0000313|EMBL:PAV91381.1, ECO:0000313|Proteomes:UP000218231}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=PF1309 {ECO:0000313|EMBL:PAV91381.1};
RA Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL Curr. Biol. 0:0-0(2017).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-
CC bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-
CC diacyl-sn-glycerol + H(+); Xref=Rhea:RHEA:33179, ChEBI:CHEBI:15377,
CC ChEBI:CHEBI:15378, ChEBI:CHEBI:17815, ChEBI:CHEBI:58456,
CC ChEBI:CHEBI:203600; EC=3.1.4.11;
CC Evidence={ECO:0000256|RuleBase:RU361133};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PAV91381.1}.
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DR EMBL; LIAE01006322; PAV91381.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A2LYQ2; -.
DR Proteomes; UP000218231; Unassembled WGS sequence.
DR GO; GO:0004435; F:phosphatidylinositol phospholipase C activity; IEA:UniProtKB-EC.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0016042; P:lipid catabolic process; IEA:UniProtKB-KW.
DR CDD; cd10341; SH2_N-SH2_PLC_gamma_like; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.20.20.190; Phosphatidylinositol (PI) phosphodiesterase; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 2.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR001192; PI-PLC_fam.
DR InterPro; IPR035024; PLC-gamma_N-SH2.
DR InterPro; IPR017946; PLC-like_Pdiesterase_TIM-brl.
DR InterPro; IPR000909; PLipase_C_PInositol-sp_X_dom.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR PANTHER; PTHR10336:SF36; 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA PLC-3; 1.
DR PANTHER; PTHR10336; PHOSPHOINOSITIDE-SPECIFIC PHOSPHOLIPASE C FAMILY PROTEIN; 1.
DR Pfam; PF00388; PI-PLC-X; 1.
DR Pfam; PF00017; SH2; 2.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR00390; PHPHLIPASEC.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00148; PLCXc; 1.
DR SMART; SM00252; SH2; 2.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF51695; PLC-like phosphodiesterases; 1.
DR SUPFAM; SSF55550; SH2 domain; 2.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS50007; PIPLC_X_DOMAIN; 1.
DR PROSITE; PS50001; SH2; 2.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Hydrolase {ECO:0000256|RuleBase:RU361133};
KW Lipid degradation {ECO:0000256|RuleBase:RU361133};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098,
KW ECO:0000256|RuleBase:RU361133};
KW Reference proteome {ECO:0000313|Proteomes:UP000218231};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 612..711
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 722..811
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 839..897
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 1..37
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..36
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 971 AA; 112426 MW; 7D9C1E4BAB673B95 CRC64;
MSSSSGSNRS KSNSTVSPST LPHTNSLTSV HHASASPKTR VYNKIHEMDF TKMFMAMEKG
HKVCKLNVNK RWDPAYKHLM LHKESRQLFL TKLEQTAVRS RPNVLDIRHV REVQTLDYKL
NTIKIQDKWK KDKEIQNFEP LKILVISYGV GFTLNNWILL FETVEACRLW SQGVHNLMLE
TRDRDTSSHP QRVDRFIHKQ FMAIAGPNDT VARKHMKPFV QTSLQFKVQS KQLQEVTEDD
MTLSQFSKAT RQLIHIPQLF TTLFSDLMKE DTKNDENKND PNGKITFDKF VLFLKNKQCD
EMATNKHRVS EFLQRYLPQE ISHIDPEPSM SIMEFCDFLF SRENSLWDIM NEKVTHDMTR
PLSHYWIASS HNTYLTGDQL RSESSLDSYA QALLMGCRCI ELDCWDGQKK PNSNEFYDIV
IYHGYTMTSK LLLRDVLYTI KHYAFITSEY PVILSIEDNC SVPAQRLLAQ EMREILGEYL
LITPVSRDET QLPSPAAMKK KIILKHKKLP IESDNLAVVV TSNDDFQDTD ILARDCIRKG
ILQLKDSTSH EWMSHVFVLF PDRLCYLLEP CTTDEASLKD DSLSMLGEDD KEEESPTGFG
VRPEEMHITE EWFHGKCGRE DAKKRIEEHK DKGDGLFMIR DSNLFIGDYS LSILHNGRVH
HVRIRSKIID KEKKYYFLDN KVCDTLYELV SYYTRHYLST SDFKMVLTTP CPQPQPHLNQ
PWFSATADKK KAEELLNRVT EDGAFLVRTS SSDTSVFVLS LRVDGEFWHY RLKRDGRIFV
VNQTVFENLN QIVDYYSSRE FVRGISLRFP VNERDVNQYT SGEMSEAAPG CYMDLKDLDK
EVQARAIRPY RGTADDDLSF PANAIITVLR KEEGLWRGRY GSATGWFPSA YVQEVLPEKS
TNSGDDNNGY NTIELAGTLI ERTTDGDKPF AIKISQSGQH WTGQQWILAA NCRNMLIPKV
VKRFIFSYRR S
//
