ID   A0A2A2M274_9BILA        Unreviewed;       317 AA.
AC   A0A2A2M274;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   RecName: Full=Dihydroprymidine dehydrogenase domain-containing protein {ECO:0000259|Pfam:PF14691};
GN   ORFNames=WR25_23915 {ECO:0000313|EMBL:PAV92483.1};
OS   Diploscapter pachys.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Diploscapter.
OX   NCBI_TaxID=2018661 {ECO:0000313|EMBL:PAV92483.1, ECO:0000313|Proteomes:UP000218231};
RN   [1] {ECO:0000313|EMBL:PAV92483.1, ECO:0000313|Proteomes:UP000218231}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=PF1309 {ECO:0000313|EMBL:PAV92483.1};
RA   Fradin H., Zegar C., Gutwein M., Lucas J., Kovtun M., Corcoran D.,
RA   Baugh L.R., Kiontke K., Gunsalus K., Fitch D.H., Piano F.;
RT   "Genome architecture and evolution of a unichromosomal asexual nematode.";
RL   Curr. Biol. 0:0-0(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAV92483.1}.
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DR   EMBL; LIAE01006180; PAV92483.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A2M274; -.
DR   STRING; 2018661.A0A2A2M274; -.
DR   Proteomes; UP000218231; Unassembled WGS sequence.
DR   GO; GO:0051536; F:iron-sulfur cluster binding; IEA:InterPro.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   Gene3D; 1.10.1060.10; Alpha-helical ferredoxin; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR028261; DPD_II.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR009051; Helical_ferredxn.
DR   PANTHER; PTHR43100; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR   PANTHER; PTHR43100:SF1; GLUTAMATE SYNTHASE [NADPH] SMALL CHAIN; 1.
DR   Pfam; PF14691; Fer4_20; 1.
DR   Pfam; PF13450; NAD_binding_8; 1.
DR   PRINTS; PR00419; ADXRDTASE.
DR   SUPFAM; SSF46548; alpha-helical ferredoxin; 1.
DR   SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218231}.
FT   DOMAIN          156..264
FT                   /note="Dihydroprymidine dehydrogenase"
FT                   /evidence="ECO:0000259|Pfam:PF14691"
FT   REGION          47..84
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        47..63
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        64..80
FT                   /note="Acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   317 AA;  35825 MW;  484880A8C9A3701A CRC64;
     MEKIIFFYFR ALSMDMQIAA TEKSARKKIG AAKKKISIEG RKRLNSKTLR PQDIAGFERE
     TDLQDANELE EEEENKSDRD EGSDEEVGLR AFLGLLETSL ISVPFQFGKK HTTVDIENIS
     VPPHLKKNDE PLDKLRGFVK YQRQKKIYRN PEERAKDWEE VYDFEAIRSN IREQAARCMD
     CGVPFCQGHT GCPLGNIIPK WNDYVFKKNW RQALEQLLQT NNFPEFTGRV CPAPCEGACC
     VAINAPAVTI KSIECAIIDY SFMQGWIKPQ KPTESTGKRI AIIGSGPAGL AAAAQLIKVG
     HTVVVYERKN RIGGLLR
//