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Database: UniProt
Entry: A0A2A2RYL7_9BACT
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ID   A0A2A2RYL7_9BACT        Unreviewed;       350 AA.
AC   A0A2A2RYL7;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   08-MAY-2019, entry version 7.
DE   RecName: Full=Phospho-2-dehydro-3-deoxyheptonate aldolase {ECO:0000256|PIRNR:PIRNR001361};
DE            EC=2.5.1.54 {ECO:0000256|PIRNR:PIRNR001361};
GN   ORFNames=B9S33_02450 {ECO:0000313|EMBL:PAW89902.1};
OS   Pedosphaera sp. Tous-C6FEB.
OC   Bacteria; Verrucomicrobia; Verrucomicrobiae; Verrucomicrobiales;
OC   Verrucomicrobia subdivision 3; Pedosphaera.
OX   NCBI_TaxID=1982324 {ECO:0000313|EMBL:PAW89902.1, ECO:0000313|Proteomes:UP000218585};
RN   [1] {ECO:0000313|EMBL:PAW89902.1, ECO:0000313|Proteomes:UP000218585}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tous-C6FEB {ECO:0000313|EMBL:PAW89902.1};
RA   Cabello-Yeves P.J., Ghai R., Mehrshad M., Picazo A., Camacho A.,
RA   Rodriguez-Valera F.;
RT   "Genome diversity of Verrucomicrobia from freshwater lakes.";
RL   Submitted (APR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Stereospecific condensation of phosphoenolpyruvate (PEP)
CC       and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-
CC       arabino-heptulosonate-7-phosphate (DAHP).
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=D-erythrose 4-phosphate + H2O + phosphoenolpyruvate = 7-
CC         phospho-2-dehydro-3-deoxy-D-arabino-heptonate + phosphate;
CC         Xref=Rhea:RHEA:14717, ChEBI:CHEBI:15377, ChEBI:CHEBI:16897,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:58394, ChEBI:CHEBI:58702;
CC         EC=2.5.1.54; Evidence={ECO:0000256|PIRNR:PIRNR001361};
CC   -!- PATHWAY: Metabolic intermediate biosynthesis; chorismate
CC       biosynthesis; chorismate from D-erythrose 4-phosphate and
CC       phosphoenolpyruvate: step 1/7. {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- SIMILARITY: Belongs to the class-I DAHP synthase family.
CC       {ECO:0000256|PIRNR:PIRNR001361}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PAW89902.1}.
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DR   EMBL; NEUT01000010; PAW89902.1; -; Genomic_DNA.
DR   UniPathway; UPA00053; UER00084.
DR   Proteomes; UP000218585; Unassembled WGS sequence.
DR   GO; GO:0003849; F:3-deoxy-7-phosphoheptulonate synthase activity; IEA:UniProtKB-EC.
DR   GO; GO:0009073; P:aromatic amino acid family biosynthetic process; IEA:UniProtKB-KW.
DR   GO; GO:0009423; P:chorismate biosynthetic process; IEA:UniProtKB-UniPathway.
DR   Gene3D; 3.20.20.70; -; 1.
DR   InterPro; IPR013785; Aldolase_TIM.
DR   InterPro; IPR006218; DAHP1/KDSA.
DR   InterPro; IPR006219; DHAP_synth_1.
DR   PANTHER; PTHR21225; PTHR21225; 1.
DR   Pfam; PF00793; DAHP_synth_1; 1.
DR   PIRSF; PIRSF001361; DAHP_synthase; 1.
DR   TIGRFAMs; TIGR00034; aroFGH; 1.
PE   3: Inferred from homology;
KW   Amino-acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Aromatic amino acid biosynthesis {ECO:0000256|PIRNR:PIRNR001361};
KW   Complete proteome {ECO:0000313|Proteomes:UP000218585};
KW   Transferase {ECO:0000256|PIRNR:PIRNR001361,
KW   ECO:0000256|SAAS:SAAS00080156}.
FT   DOMAIN       43    338       DAHP_synth_1. {ECO:0000259|Pfam:PF00793}.
SQ   SEQUENCE   350 AA;  38240 MW;  9F43DD5A879CFAE8 CRC64;
     MQSTHNWHIQ ATRPIITPRQ LSEALPLTPA VAGTVVAGRH TVQNILDRKD GRLLVIVGPC
     SIHDPVAAVD YARHLLPLRQ ELKDRMEIIM RVYFEKPRTI LGWKGLINDP HLNNSCDIET
     GLKVGRRLLL DIVGLGMPVA TEFLDPVVPQ YLADLVSWAA VGARTTESQT HREMASGLSM
     PVGFKNGTDG SLETAVNAMK AARSSHSFLG IDPDGRTCIV QTTGNKWGHL VLRGGKHAPN
     YDERSIAEAV QQLTAQGLPG ELIVDCSHAN SGKKHTRQQT VWDHVIEQHR AGSRAVIGMM
     VESNLEEGSQ PLTEDLKQLR YGVSVTDACL GWPDTAKLLR NGHAMLAPAS
//
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