ID   A0A2A2TL03_9CYAN        Unreviewed;       715 AA.
AC   A0A2A2TL03;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=Peptidase S8 {ECO:0000313|EMBL:PAX57226.1};
GN   ORFNames=CK510_08900 {ECO:0000313|EMBL:PAX57226.1};
OS   Calothrix elsteri CCALA 953.
OC   Bacteria; Cyanobacteriota; Cyanophyceae; Nostocales; Calotrichaceae;
OC   Calothrix.
OX   NCBI_TaxID=987040 {ECO:0000313|EMBL:PAX57226.1, ECO:0000313|Proteomes:UP000218238};
RN   [1] {ECO:0000313|EMBL:PAX57226.1, ECO:0000313|Proteomes:UP000218238}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=CCALA 953 {ECO:0000313|EMBL:PAX57226.1,
RC   ECO:0000313|Proteomes:UP000218238};
RA   Gagunashvili A.N., Elster J., Andresson O.S.;
RT   "Draft genome sequence of filamentous cyanobacterium Calothrix elsteri
RT   CCALA 953.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the peptidase S8 family. {ECO:0000256|PROSITE-
CC       ProRule:PRU01240}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PAX57226.1}.
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DR   EMBL; NTFS01000070; PAX57226.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A2TL03; -.
DR   OrthoDB; 9798386at2; -.
DR   Proteomes; UP000218238; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0012505; C:endomembrane system; IEA:UniProt.
DR   GO; GO:0043231; C:intracellular membrane-bounded organelle; IEA:UniProt.
DR   GO; GO:0004252; F:serine-type endopeptidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0006508; P:proteolysis; IEA:UniProtKB-KW.
DR   CDD; cd07498; Peptidases_S8_15; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.40.50.200; Peptidase S8/S53 domain; 1.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR002884; P_dom.
DR   InterPro; IPR034054; Pep_S8_PrcA.
DR   InterPro; IPR000209; Peptidase_S8/S53_dom.
DR   InterPro; IPR036852; Peptidase_S8/S53_dom_sf.
DR   InterPro; IPR022398; Peptidase_S8_His-AS.
DR   InterPro; IPR023828; Peptidase_S8_Ser-AS.
DR   InterPro; IPR015500; Peptidase_S8_subtilisin-rel.
DR   PANTHER; PTHR42884:SF14; NEUROENDOCRINE CONVERTASE 1; 1.
DR   PANTHER; PTHR42884; PROPROTEIN CONVERTASE SUBTILISIN/KEXIN-RELATED; 1.
DR   Pfam; PF01483; P_proprotein; 1.
DR   Pfam; PF00082; Peptidase_S8; 1.
DR   PRINTS; PR00723; SUBTILISIN.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF52743; Subtilisin-like; 1.
DR   PROSITE; PS51829; P_HOMO_B; 1.
DR   PROSITE; PS51892; SUBTILASE; 1.
DR   PROSITE; PS00137; SUBTILASE_HIS; 1.
DR   PROSITE; PS00138; SUBTILASE_SER; 1.
PE   3: Inferred from homology;
KW   Calcium {ECO:0000256|ARBA:ARBA00022837};
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW   ProRule:PRU01240};
KW   Protease {ECO:0000256|ARBA:ARBA00022670, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}; Reference proteome {ECO:0000313|Proteomes:UP000218238};
KW   Serine protease {ECO:0000256|ARBA:ARBA00022825, ECO:0000256|PROSITE-
KW   ProRule:PRU01240}.
FT   DOMAIN          579..715
FT                   /note="P/Homo B"
FT                   /evidence="ECO:0000259|PROSITE:PS51829"
FT   ACT_SITE        243
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        281
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
FT   ACT_SITE        495
FT                   /note="Charge relay system"
FT                   /evidence="ECO:0000256|PIRSR:PIRSR615500-1,
FT                   ECO:0000256|PROSITE-ProRule:PRU01240"
SQ   SEQUENCE   715 AA;  76959 MW;  24FAB3B2E44D290E CRC64;
     MNLNQSNFSA SVGVPANSLG IILQRGGEEL ILEKVSDRFT VRPQQNLSSP GQLGLSIGKW
     QRSIPQANLE VFTVEASQLD AAIANARNSE NVAFASHVYQ IKNSNSQNSP STFVHVDDQI
     TIQFALGVDS GKIKTITAAF SLVADKPVVG LANTFVFRVG KDATENPIKI ANRLQSQPEV
     LAAEPNIIIR AEPHYKPRDL LYPEQWYLNH NNGREVAAGS HISVEKAWDI TRGLRSVVVA
     VVDDSFDLNH PDFQGNGKIV APLNLRDNNF LPLPNSTETS HGTACAGVAV AEENGTGIAG
     VAPGCALMPI RTTGDLDDES IEKIFDWAVE KGASVISCSW GAAAVYFPLS IRQRAAISRA
     ATQGRNGKGC VILFAAGNAN RPINGSVNEK NWVKNVLNGN TKWLSGFAVH PDAIAVSAST
     SFGKKAAYSN WGTNISVCAP SNNAPPGMWF QTTGYIYTQP GIAVSLPGLG VLTADQLGAA
     GYDKEDFTRD FGGTSSATPV VAGVAALVLS ANPDLTAPQV RKILQDTADK IVDTEPDPQL
     GMRAGTYDNS GHSQWFGYGK VNAFKAVQAA QQLRVTGVTG AVAAKEIIGR NNNKLAIPDN
     DRQGIRSINI ITETSLVRDI QVTVSITHDF LGDLEIYLIA PNNQTCLLQS RTLGRRQELQ
     QTYEVRYSVG VATRSHPILS QLLNIPARGR WTLWVIDYVE QDKGTLNSWE LKLGI
//