ID A0A2A3E074_APICC Unreviewed; 806 AA.
AC A0A2A3E074;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Very low-density lipoprotein receptor {ECO:0000313|EMBL:PBC25137.1};
GN ORFNames=APICC_01964 {ECO:0000313|EMBL:PBC25137.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC25137.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC25137.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC25137.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KZ288507; PBC25137.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3E074; -.
DR STRING; 94128.A0A2A3E074; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR CDD; cd00054; EGF_CA; 2.
DR CDD; cd00112; LDLa; 5.
DR Gene3D; 2.40.128.620; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 5.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR22722; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN 2-RELATED; 1.
DR PANTHER; PTHR22722:SF14; MEGALIN, ISOFORM A; 1.
DR Pfam; PF07645; EGF_CA; 1.
DR Pfam; PF14670; FXa_inhibition; 2.
DR Pfam; PF00057; Ldl_recept_a; 5.
DR Pfam; PF00058; Ldl_recept_b; 3.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00179; EGF_CA; 2.
DR SMART; SM00192; LDLa; 6.
DR SMART; SM00135; LY; 5.
DR SUPFAM; SSF57184; Growth factor receptor domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 6.
DR SUPFAM; SSF63825; YWTD domain; 1.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01187; EGF_CA; 1.
DR PROSITE; PS01209; LDLRA_1; 4.
DR PROSITE; PS50068; LDLRA_2; 6.
DR PROSITE; PS51120; LDLRB; 4.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:PBC25137.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:PBC25137.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..17
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 18..806
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012946252"
FT TRANSMEM 725..749
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 301..315
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 403..446
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 447..489
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 490..533
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 534..578
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 784..806
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 792..806
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 30..42
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 37..55
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 70..82
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 77..95
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 89..104
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 109..121
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 116..134
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 128..143
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 217..232
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 247..265
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 806 AA; 90196 MW; B70CF8BF3EC2D7B2 CRC64;
MLLMILQLTC IVHLASIDDD NDTLPGPQKC SDTEFKCMNG KCIPGTWHCD GDNDCRDGSD
EDPTICNDTC RSDEFTCANK HCIQKTWICD SDDDCGDGSD EKDCKPVTCS PSEFACSDNY
CITSQWRCDG DFDCPDRRDE IGCKYANGER HVHCNKKGEF DCGDDFSCIH ESWVCDREKD
CPNGADELPK VCHNFTCRPD QFQCQHIRNC ISGHLYCNGK IECADGSDEK NCTTKAIGCD
PSTQFECSEG SCISLSSVCN KNRDCIGWED ENEKLCGINE CLKNNGGCSQ ICIDLPIGFR
CDCSIGYRLI DNRTCDDIDE CLEPGTCSQF CMNEKGSFKC SCAAGYLKDP SNHTRCKAAE
GHASLLFTRR HDIRKVALDR LEMTSIVKDT KMAAALDFVF RTGMIFWSDS SEKKIYKAPI
DEGNERTVVI DDGLTTSDGL AVDWIYSHIY WTDSKKNTIE LANFEGNMRK TLIQDHIQEP
RAIALNPLEG WMFWTDWSDE ARIEKAGMDG SHRTVIVDND VQWPNGLTLD LIGKKIYWVD
AKLYIIGSCN YDGTGIRTVL YSPEVLRHPF SITTFEDYVY WTDWDKEAIF KANKFTGQSV
EAVMSLRALK YPMVVHVYHP YRQPDGMNQC QAVNGHCSHL CLPAPRINSK SPLLSCACPD
GLKLLSDGLM CVEKVSTTVA PTTQEINKPF KRLELFNTTT TIDSIHSIDG NEEDGLTSES
TDPGLVAGIV IGVTSLGLLL LALVAVLCYR HYLHRNVTSM NFDNPVYRKT TEDQFSLEKN
RFPLPTATVG EEAQEPLTSP GTNDYV
//
