ID A0A2A3E0U5_APICC Unreviewed; 416 AA.
AC A0A2A3E0U5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Tumor susceptibility protein {ECO:0000313|EMBL:PBC25338.1};
GN ORFNames=APICC_05181 {ECO:0000313|EMBL:PBC25338.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC25338.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC25338.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC25338.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. UEV
CC subfamily. {ECO:0000256|ARBA:ARBA00009594}.
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DR EMBL; KZ288470; PBC25338.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3E0U5; -.
DR STRING; 94128.A0A2A3E0U5; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0036211; P:protein modification process; IEA:InterPro.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-UniRule.
DR Gene3D; 6.10.140.820; -; 1.
DR Gene3D; 6.10.250.370; -; 1.
DR Gene3D; 3.10.110.10; Ubiquitin Conjugating Enzyme; 1.
DR InterPro; IPR037202; ESCRT_assembly_dom.
DR InterPro; IPR017916; SB_dom.
DR InterPro; IPR016135; UBQ-conjugating_enzyme/RWD.
DR InterPro; IPR008883; UEV_N.
DR PANTHER; PTHR23306:SF3; TUMOR SUPPRESSOR PROTEIN 101; 1.
DR PANTHER; PTHR23306; TUMOR SUSCEPTIBILITY GENE 101 PROTEIN-RELATED; 1.
DR Pfam; PF05743; UEV; 1.
DR Pfam; PF09454; Vps23_core; 1.
DR SUPFAM; SSF140111; Endosomal sorting complex assembly domain; 1.
DR SUPFAM; SSF54495; UBC-like; 1.
DR PROSITE; PS51312; SB; 1.
DR PROSITE; PS51322; UEV; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|SAM:Coils};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 3..146
FT /note="UEV"
FT /evidence="ECO:0000259|PROSITE:PS51322"
FT DOMAIN 350..416
FT /note="SB"
FT /evidence="ECO:0000259|PROSITE:PS51312"
FT COILED 268..337
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 416 AA; 46570 MW; 8B78077CAAEF7634 CRC64;
MTSIDEGKLK QSLSKYQNSD ITKKHVMKVL NLYKGLKYNV EPFVFNDGSR KELFNLQGTI
PVSYKGNYYN IPICIWLMDT HPNNAPMCYV KPTADMSIKV SMFVDHNGKI YLPYLHDWLP
HSSDLLSLIQ IMIVTFGEQP PVYAKPRQGI QTSSTPYPIQ SFMPVPGSGT HIPGSSFPSY
PQNSQYTGGN NIYPPYMSTT SSGFPYQGYG SYGGTASNYP SQSCTGSFQY PPSTQPSPTV
PATVGASGTI TEEHIRASLL SAVEDKLRRR LKEQFSQLSA ELETLRRTQQ ELTSGSAHLT
DLFDKLKKEK TELEKNITIL QDKEAELEKE IAKLSDNQSI DVDEAVTTIA PLYKQMLNAF
AEEAATEDAI YYLGEALRCG IIDLDAFLKQ VRQLSRRQFM LRALMQRCRQ KAGLAG
//
