ID A0A2A3E337_APICC Unreviewed; 785 AA.
AC A0A2A3E337;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=FYVE, RhoGEF and PH domain-containing protein {ECO:0000313|EMBL:PBC25511.1};
GN ORFNames=APICC_05075 {ECO:0000313|EMBL:PBC25511.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC25511.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC25511.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC25511.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
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DR EMBL; KZ288455; PBC25511.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3E337; -.
DR STRING; 94128.A0A2A3E337; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd00065; FYVE_like_SF; 1.
DR CDD; cd13388; PH1_FGD1-4_like; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR12673; FACIOGENITAL DYSPLASIA PROTEIN; 1.
DR PANTHER; PTHR12673:SF241; PROTEIN CBG10230; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF00169; PH; 2.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 232..427
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 456..554
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 575..632
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT DOMAIN 657..761
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 182..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 785 AA; 90980 MW; 6AE1393863CC6995 CRC64;
MRKFDTGRFV DSYQHGIILR MQQNRLIDVS LWTTRPIFKF NDRKNFNRPL KMFVSRTQTS
NSTFYTELEP DEVMDRKTDL NELKECQDKD FNHSDIITES EKQENYDGHS FRKIASFGAF
PRFRSFIMST ENSMDQSDTQ DGEENSMEVP FVRISRNVLE YRNSRYLTTD RNSHRYAVES
FAISESESEE ESEGAKSSET DSAIVVNHNT NDLNLELKSV GNISYLDSKK KNARRVAEEL
LVTEKNYVNV LRLIDQVFQF KIDQENRAHP MFPPETVQHM FSNIKSIYKF HNDFLLPQLQ
ERMQNWDSNP RIGDIMKNFA PFLKMYTEYV KNFDYAMNLI QSLQTKVTRF AAIIDEIQKL
DECAKLSLPH HMLSPIQRLP RYELLLKDYL RNLTEENADY KDTKNMAFFL VEALELVSTA
ANHTNDAMKK IDKFKKLLEI QESIYDTTDL VSATRELIKE GRIVKISARS GDHQERQLFL
FSDLLLLCSI RLIPGPLYRL RAKFLIENLQ IIEGDNLETA NTFYIRDEDK SVELYTHAAE
EKAAWLNALF DTMQEMMKRK ASLKTGDVKT LVLKSDDISK CMICEVIFSV MKRKHNCRAC
GIIVCGKCSN QKLLFEDNKN TRVCRLCYTS LTLVKSPSST STSGPVPSLL QVSASASSVI
SGYLMLKTQA SKPWTRRWFA LHADFVLYTF KSESENMALT ATPMPGFIVT EGIKLSDEDP
LSFKDRSRAL KMHHSRKSYY LQALSDEDKR KWLYALQLAT KAELPSFVTV ENEDAQKNQS
VVQMR
//
