ID A0A2A3E416_APICC Unreviewed; 866 AA.
AC A0A2A3E416;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Metabotropic glutamate receptor {ECO:0000313|EMBL:PBC25899.1};
GN ORFNames=APICC_01549 {ECO:0000313|EMBL:PBC25899.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC25899.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC25899.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC25899.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR EMBL; KZ288427; PBC25899.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3E416; -.
DR STRING; 94128.A0A2A3E416; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15045; 7tmC_mGluRs; 1.
DR CDD; cd06362; PBP1_mGluR; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060:SF176; MANGETOUT, ISOFORM G; 1.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:PBC25899.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 556..581
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 593..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 620..639
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 716..735
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 747..769
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 775..798
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 556..820
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 866 AA; 98183 MW; C088B43C1508D98A CRC64;
MLIASLFEFI LSIEPNIENV RVLYANVTGD LVLGGLFPVH RKGINGENCG AIQMEDGIQP
LEAMLYTIER INKNPEILPG IQLGAVAFDT CDNPTYALDR VFYFIKVAIL GAESSSVTIQ
VASVLALFPI PQISYMATSP FLSSKEKFPR FFRTVPSDVN QARAMLEVLR QFQWTYVSVV
YTDSEYGDHG YEMLVSLATD YSICFSSPHR ISKDRFKDDD YDFVVRTIAE KTDVKVVVLF
AEKATTLRVL EAARRVDVGS RFVWLCSDAW PDHNDINCQQ TTVLEGALAV QPLYAPLSGF
DEYFTGLTLD HEQKNPWFPE FWQTYHNCVY VEEAKYFSSK KSGLINCRDP KLKIKRSNGY
KQRRFLHFVR DAVYAVAYAL HDMQKNVCGE NWRGLCDKMR PPDEDIFFQY LTEVSFKDEA
GNGFGFVDAV DGPPRYSILN YQRKVNGSYH WTVVGNYTLN EREQPILQLD RDKLRFRGEQ
ATEFPTSSCS HPCGSNRIMV RRKEDPCCWT CQSCGLYRYK VDEQRCEDCI LGTIPTENGT
GCDPIPEEFV EYSNPWAIVA ITIAVCGIGL TMFVCSVFWI YRETPMIKAS GRELSFLLLL
GAFGCFSMTF AVVAKPSVET CAIVRFGIGF CYTVCYAALT TKINRIHRIF NDPGRSPHKR
RFTSPRSQLT IASMLILIEI VFDVSWLLKE QPAVEHSYSR RSANVRICRG SENGSYVIGL
FYPFLLTVAS TFYAIKTRKC PEGFNETRCI AFANYATIIL WLAFVPLYLA STRNVIKVIT
LALSLSLNGL VQLICLFLPK VYVVLIKPEK NTRELVMARH AGSSYPTTPC TPITPELPSG
LPFIIDRDRS KSLSFANHFR SDKISL
//
