ID A0A2A3E5P7_APICC Unreviewed; 632 AA.
AC A0A2A3E5P7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 13-SEP-2023, entry version 18.
DE RecName: Full=guanylate cyclase {ECO:0000256|ARBA:ARBA00012202};
DE EC=4.6.1.2 {ECO:0000256|ARBA:ARBA00012202};
GN ORFNames=APICC_09815 {ECO:0000313|EMBL:PBC27018.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC27018.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC27018.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC27018.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KZ288360; PBC27018.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3E5P7; -.
DR STRING; 94128.A0A2A3E5P7; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0004383; F:guanylate cyclase activity; IEA:UniProtKB-EC.
DR GO; GO:0020037; F:heme binding; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd07302; CHD; 1.
DR Gene3D; 6.10.250.780; -; 1.
DR Gene3D; 3.90.1520.10; H-NOX domain; 1.
DR Gene3D; 3.30.450.260; Haem NO binding associated domain; 1.
DR Gene3D; 3.30.70.1230; Nucleotide cyclase; 1.
DR InterPro; IPR001054; A/G_cyclase.
DR InterPro; IPR038158; H-NOX_domain_sf.
DR InterPro; IPR011644; Heme_NO-bd.
DR InterPro; IPR011645; HNOB_dom_associated.
DR InterPro; IPR042463; HNOB_dom_associated_sf.
DR InterPro; IPR024096; NO_sig/Golgi_transp_ligand-bd.
DR InterPro; IPR029787; Nucleotide_cyclase.
DR PANTHER; PTHR45655; GUANYLATE CYCLASE SOLUBLE SUBUNIT BETA-2; 1.
DR PANTHER; PTHR45655:SF5; SOLUBLE GUANYLATE CYCLASE 89DA-RELATED; 1.
DR Pfam; PF00211; Guanylate_cyc; 1.
DR Pfam; PF07700; HNOB; 1.
DR Pfam; PF07701; HNOBA; 1.
DR SMART; SM00044; CYCc; 1.
DR SUPFAM; SSF111126; Ligand-binding domain in the NO signalling and Golgi transport; 1.
DR SUPFAM; SSF55073; Nucleotide cyclase; 1.
DR PROSITE; PS50125; GUANYLATE_CYCLASE_2; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Lyase {ECO:0000256|ARBA:ARBA00023239};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00023134};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457}.
FT DOMAIN 436..562
FT /note="Guanylate cyclase"
FT /evidence="ECO:0000259|PROSITE:PS50125"
SQ SEQUENCE 632 AA; 71579 MW; 1F4CECA42AA990FB CRC64;
MYGMLLESVQ HFVQLEYGED MWLQLLERAD CKHMVFNTRQ TYPDELMTNL AAALAEFNGE
SVENVMQFFG KCFVRFFSNL GYACMIKATG RYFCDFLQNV DNIHMQMRFT YPKMKSPSMY
TTHIDPQGVE LVYRSTRKGF THYLMGQLFQ IAKELYETDL VIRVLGSSNN IPGSRSVMVK
FRIDFDNREY IAKNNRMKTP LSRELAPVSI SFLLRLFPFG AIIDKDMRIL GAGDKLLQAW
GGSSSSILNK HVTDVFKLRR PKGISFTWGN VIYLHSVMFE LEMIRLNDQN ASSNTVNTPS
TSTGLDRRGS QGARSILLKG QMRYIEDLKA IIFLCSPLIN SLDELLNMGL YLNDLNPHGL
SRELVLAGWQ HCGRLEMMFE RAEQRSTELE NSYALLDRWK NKSDELLYSM IPQTVADRLR
AGASPLSTCE SFESISVLFC ELCDFDYSTI EGAMDIVSSM NAVFSCFDSL MDEFNVYKVE
TVGRIYMAAS GAPDRTENHA QNIADVSLQL LKHVRSLKLP SGLDIQIRIG IHSGPAVAGV
VGIKVPRYCF FGDTVNTASR MQTTSLPGRV HISSDAKALL SLDRYHVESR GLVWVKGKGN
METYWLSDKV EANVKLMEEQ AVRPEGLLVT DI
//