ID A0A2A3E6R5_APICC Unreviewed; 1625 AA.
AC A0A2A3E6R5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Low-density lipoprotein receptor-related protein {ECO:0000313|EMBL:PBC27447.1};
GN ORFNames=APICC_00873 {ECO:0000313|EMBL:PBC27447.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC27447.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC27447.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC27447.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00124}.
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DR EMBL; KZ288349; PBC27447.1; -; Genomic_DNA.
DR STRING; 94128.A0A2A3E6R5; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0006897; P:endocytosis; IEA:UniProtKB-KW.
DR GO; GO:0016055; P:Wnt signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd00112; LDLa; 3.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 3.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 4.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR000033; LDLR_classB_rpt.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR PANTHER; PTHR46513:SF36; LOW-DENSITY LIPOPROTEIN RECEPTOR-RELATED PROTEIN; 1.
DR PANTHER; PTHR46513; VITELLOGENIN RECEPTOR-LIKE PROTEIN-RELATED-RELATED; 1.
DR Pfam; PF14670; FXa_inhibition; 3.
DR Pfam; PF00057; Ldl_recept_a; 3.
DR Pfam; PF00058; Ldl_recept_b; 10.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00181; EGF; 4.
DR SMART; SM00192; LDLa; 3.
DR SMART; SM00135; LY; 20.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57424; LDL receptor-like module; 3.
DR SUPFAM; SSF63825; YWTD domain; 4.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 3.
DR PROSITE; PS51120; LDLRB; 11.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Endocytosis {ECO:0000256|ARBA:ARBA00022583};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Lipoprotein {ECO:0000313|EMBL:PBC27447.1};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:PBC27447.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1408..1432
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 132..174
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 175..220
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 221..263
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 399..441
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 442..484
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 485..529
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 530..572
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT DOMAIN 642..657
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS01186"
FT REPEAT 704..746
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 747..789
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 790..832
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REPEAT 1101..1143
FT /note="LDL-receptor class B"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00461"
FT REGION 1495..1625
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1495..1544
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1594..1612
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 1300..1315
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1318..1330
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1325..1343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 1337..1352
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 1625 AA; 182900 MW; 80257C1B56DA183F CRC64;
MGRWETGFEP SGKNRSSDRR AERSEIVQFC FPRVLHVATW ETGTPTLLFV TQKDIRMANA
SRTNKVITVI KDLSEGAALD FYFEHELVCW SDSGLEIIQC IRTNGTHTGE KTIVVNSSLI
SPDGLACDWY TGKLYWTDGE KNRIEVTSID GRHRKVLFWT DIYQPRAIAL VPMKSILFWT
DWGDVPKIER AAMNGDPSTR EVIISDDIFW PNGLTVDYEN ELVYWVDGRL KFIAVMDYYG
KNRRKVIEQG LDYPFAVTFF DHRLYWTDWK TWCVHSYDVR QNQAHPRELL HGEYIPGDIE
VWDVKRQPYG SHPCEKNNGN CSHLCLLSMT EPGYSCACPT GVKLVDNLTC AEGPEELLLI
VQRNEICRIS LDSPDYTNFV LPLTGIKHAI AIDFDPVQEM LYWTDEEARA IRRASLDGSN
QENIITTEVK NPDGIAVDWL ARNLYWTDTG TDRIEVARLN GTSRKVLINE DLIEPRAIAL
APELGWMFWT DWNEKRPKIE RSNLDGTERI LLINKDIVWP NGIALDLARW KIYWCDAKTD
KIEVCNMDGT NRREVITDNL PHLFGLSLLG DYLYWTDWQR RSVDRAHKLT GGEREVIVDQ
VPNVMGLKAV HLGKVNGTNP CVKSNGGCSH LCLNRPGNKY VCACQIGYEL TKDKKTCVVP
DAFMLFARKE NIGRISIENA NNDNIIPLTG VKDASALDFN IVDNRIYWTD VKLKTITRAF
INGSDIERVV DLGLETPEGL AIDWIAHNLY WSDTGTRRIE MVRLEGCSRK VLIWNNIIEP
RCLALDPSKG HMYWTEWGNS GNIERSYLDG THREIILSNI GRANGLTIDH SARKLYWADL
YTPAVDSFDL RTRKRYAIIT ENIVYPFSIT QYQDYIYWTD WNTGDIEKAN KTNGANREKI
HNKLESVTDL LVFHASRQAG WNPCASKNGS CSHLCIALPG ENESISNSFK CECPTHYNLA
EDNKTCIAPK SFMMYSLRNA IFRFLPDTND CPDVVLRIQG LKHVRSIEFD PITQHIYWID
GRTLSIRKTL ENKTHSSIMI SGNSGHPVDL ALDSLGRLLF WSCAINDAIN VTKLDNASAL
GVVVKGDGEK PRNIAIHSEK RFLFWTDIGR KMRIMRSKMD GKERIVIATD LEQPTSIAVD
TISNIVYWAH GNQIEYADFD GNNRRILISP VGQGSTIYLS VFLDFIYWFD KETSSLERIN
KSGNGRKTIM NKVLTDLITV NTPQDDIMKT HICSPFRDYG GCSHFCIGTI SSRCSCPKSL
VLSEDEKTCR AAPACGTDHF TCAAPSSAVT KDCIPATWKC DGQTDCPDGS DELGCPTCNR
EQFKCQSGHC IDMSWVCDGT THCHDGLDEA HCCRPDQFQC IGNGVCISGS ALCDGWEDCA
DGSDELASAC TPANNPRQEN NSLESGKITY VIIVPIGLIA TIAAIAFGFY YCRRKFINNE
ELPDILHDSA GDPLSPKPAR LAKPMFAQKN CRKDLKIGME TVRMSMLNGS SIGSSYDRSH
ITGASSSTRG SSTGYPQETL NPPPSPATTA NSTRCSSSNA SRYKPYRYYK SINQPPPPTP
CSTDVCDESD SNYPARYRYE SEPYPPPPTP RSVYQSDAGI SCPPSPSSRS STYFSPLPPP
PSPVP
//
