ID A0A2A3E6X8_APICC Unreviewed; 778 AA.
AC A0A2A3E6X8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 21.
DE SubName: Full=Cytochrome b5-related protein {ECO:0000313|EMBL:PBC27465.1};
GN ORFNames=APICC_08462 {ECO:0000313|EMBL:PBC27465.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC27465.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC27465.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC27465.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the major royal jelly protein family.
CC {ECO:0000256|ARBA:ARBA00009127}.
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DR EMBL; KZ288349; PBC27465.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3E6X8; -.
DR STRING; 94128.A0A2A3E6X8; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0006629; P:lipid metabolic process; IEA:InterPro.
DR Gene3D; 3.10.120.10; Cytochrome b5-like heme/steroid binding domain; 1.
DR Gene3D; 2.120.10.30; TolB, C-terminal domain; 1.
DR InterPro; IPR011042; 6-blade_b-propeller_TolB-like.
DR InterPro; IPR001199; Cyt_B5-like_heme/steroid-bd.
DR InterPro; IPR036400; Cyt_B5-like_heme/steroid_sf.
DR InterPro; IPR005804; FA_desaturase_dom.
DR InterPro; IPR017996; Royal_jelly/protein_yellow.
DR PANTHER; PTHR16740; CYTOCHROME B5-RELATED PROTEIN-RELATED; 1.
DR PANTHER; PTHR16740:SF1; CYTOCHROME B5-RELATED PROTEIN-RELATED; 1.
DR Pfam; PF00173; Cyt-b5; 1.
DR Pfam; PF00487; FA_desaturase; 1.
DR Pfam; PF03022; MRJP; 1.
DR SMART; SM01117; Cyt-b5; 1.
DR SUPFAM; SSF55856; Cytochrome b5-like heme/steroid binding domain; 1.
DR SUPFAM; SSF101898; NHL repeat; 1.
DR PROSITE; PS50255; CYTOCHROME_B5_2; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 493..511
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 569..588
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 633..652
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 352..428
FT /note="Cytochrome b5 heme-binding"
FT /evidence="ECO:0000259|PROSITE:PS50255"
FT REGION 755..778
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 778 AA; 89661 MW; 82CF6CC457A4740C CRC64;
MLICSINVGV VNHTRESPTL IPYPSFEAHQ YEAGSVPEII SPFRIRVDRC ERLWVLDTGF
TDILQNPEQE APPALLVYDL KNDRLLRKFV IPEDQKTHDS LFANIALEDY SCEDTFAYLG
DLGGPGLVVY SWKSRKSWLV KHRFFQPDPQ SEEFNVSGIS FHWTDGLFGM SIAPSNDGYS
VMYFHPLSST MEYSVSTKIL RDPERANSPD NFKEFRALGS RGHNGQSSVS FLDPNTGVLF
YALTNLNAIA CWKPRNTFTL HQQGFIYQNS ITMVFPNDLK IDQNGNIWVL SDRLPTFMYA
RLDPEDYNFR ILMGSAKEAI RDTKGEKNDT MGKSESSIPG FENFPGREAK VKTGYAYLEG
RRQVDGAEDL WRIGNSLYDL EGFAKFHPGG AEWIRLTKGT DITELFQTHH LTDKATKLLP
KYFIREAVVP RKLPLTFEPN GFFSTFKRRA LEALKDVNFH QPSTKTNLIA DFLFTSSLIF
SILTAYTQSY LMIVFTGILL AWTAISGHNY LHMKDNFRMY YFDLSTMSSK DWRITHAMSH
HMYPNTLWDY EIYAFEPFIH WLPDPKKSLV MTFVSQLMSP IIWALVFYEQ AIKRYYSVFF
EYKTFEIRDA IPFFLPVLMS FFTPNFFTAV KLWLLIIMAT SFIFSIIGFN AAHHHPDIFH
DGDIYRDDYD WGVLELDAVR ERKVIDDSDF LVLTNFGLHG LHHLLPTVDH SYLPLCVNAF
EQTCKEFGIG IEKFTQWELI KGQFKQLAHR DFYSSPSGCR SKRGGNAEPS NWGLNAGR
//
