ID A0A2A3E7S9_APICC Unreviewed; 1474 AA.
AC A0A2A3E7S9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Neogenin {ECO:0000313|EMBL:PBC27758.1};
GN ORFNames=APICC_04023 {ECO:0000313|EMBL:PBC27758.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC27758.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC27758.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC27758.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the immunoglobulin superfamily. DCC family.
CC {ECO:0000256|ARBA:ARBA00009588}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; KZ288340; PBC27758.1; -; Genomic_DNA.
DR STRING; 94128.A0A2A3E7S9; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProt.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR CDD; cd00063; FN3; 6.
DR CDD; cd00096; Ig; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 10.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR010560; Neogenin_C.
DR PANTHER; PTHR44170:SF30; FIBRONECTIN TYPE-III DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR Pfam; PF00041; fn3; 6.
DR Pfam; PF07679; I-set; 1.
DR Pfam; PF13927; Ig_3; 3.
DR Pfam; PF06583; Neogenin_C; 1.
DR PRINTS; PR00014; FNTYPEIII.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 4.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 3: Inferred from homology;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..24
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 25..1474
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012878418"
FT TRANSMEM 1104..1129
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 3..117
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 124..213
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 225..314
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 319..404
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 503..594
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 600..689
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 694..788
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 798..888
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 898..995
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1000..1097
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 455..474
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1175..1238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1263..1283
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1300..1449
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1175..1226
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1300..1364
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1389..1434
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1474 AA; 163240 MW; 48ECFA47BABDE8C3 CRC64;
MEPRTLAIPL ALLTFVILAA NASGLYFTIE PQDVVVEQGN PARLDCEANS SFGKPNIQWR
TDDGQPINFI GDSYRSQLSN GSLYINSVYG TSLELTGSYQ CLASVDDIGA IVSRIATIKI
ASLPGFEKEP QDTMVYPGQI AYLSCTLLTT SSSLIIQWLK DEHPLIISTD SRMTILPSGA
LEIDNVKMKD VGSYRCNASS YGQYRLSNKA QLGLLTSDID QESTPPVFIA KPLQQVITEG
STITLECAAN GYPKPSILWL KDGVAIDLTS FKSRYSRIAA SSLVISNVEE IDNGSYQCRA
ENEVEILDAT ADLIVQVPPR FIKKPEDKIA SENQDLEFEC EIYGKPQPKI TWLKNGERIT
LSAYWQIVNG YNLRINGLLP IDAGIFQCIG TNSAGTVQAA ARLTINQPKK AISHKSTTPK
TVPKKKLLLH RQLYNKTWQH PSTLLGHTMS AFTPNPPLSI SPSDDPADLP GSVRFPNSHY
DPKSPFIDDT DSLESIEGSV PSAPRNLSLV IVTARFVTLR WQEPENTNGE ILNYYIYYKQ
EGAQRERVIN TQQKLEAVIR GLQPSMTYHF RVVALNERGS GISSEVLQVT TLTEANVPGA
PLNLEGYATS SVSIALSWEE PQVTNGKISK YIITFVEGDN EEITRETTST MHDLIDLVPY
TEYSIKVQAV NENGPGVFSR DIVVRTYSAQ PTQPPHNVTV EPVSPTSIMI RWEPPLEGQN
GIITGYKIRY RRHDRASPPV NIATEGNQRS RVLTGLEKHV VYQIRICALN VNGTGPWTEW
IQIETYETES DENRVPNTPS NLKTKVMSDY IQVFWNPPKD QSIKVKGYKL GWGKGVPDVE
VRLLDGKERS FTIDQLEPIT EYVISLRATN DAGDGQPAYA NVRTTERSVS EFSAPLLPPV
GLKASVLSDT TVVLYWTDTT LPKTQFVTDN RYYVVRYTSH HHSSNPRYKY HNATDLNCMI
NDLKPNTLYE FTVKLVKGKR ESLWSMVVSN QTQEAAPSSA PRNLTIQSIE DRPTSVLLRW
QPPKQPNGPI TGYIIFYSTD NTKWDRDWLI EGVIGDKTEF IVKGLQPSMT YYFKIQARNS
KGYGPFSTTY PFKTPQNGRG LSNILIYIIV GCSIVLVTGI AVVVVVICCK RSPDTPDRKK
GYMKDTNQKT NIKPPDLWIH HDQMELKALE KSSINGEAST SGVASNTLPR SNNQEYNQEN
VHGNSSSLDK RTYVPSYMGN TDEKCSTLSR QHSRGSHKPK LITLPVDSAS LHQPIATATP
IVNTSMSQPT IHTSCNDTPS ARQNYPRTVA QYSLSRAHIT LEPTPESSPD SCNISTSYEP
MQNQQLPYGT SSQSYSGNTQ YASGHYSNSN QPSSTSSGTD GASGSKRMQG HPLKSFSVPA
PPPQSAPSTP AQQKHGVSQV TVRPTMSGSP YKKPQSSAQL AKNRLASVSN PVHTSEEVER
LKPSYSTEEL NQEMANLEGL MKDLNAITAS EFEC
//
