ID A0A2A3E8K9_APICC Unreviewed; 1455 AA.
AC A0A2A3E8K9;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE RecName: Full=protein-tyrosine-phosphatase {ECO:0000256|ARBA:ARBA00013064};
DE EC=3.1.3.48 {ECO:0000256|ARBA:ARBA00013064};
GN ORFNames=APICC_00638 {ECO:0000313|EMBL:PBC28040.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC28040.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC28040.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC28040.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=H2O + O-phospho-L-tyrosyl-[protein] = L-tyrosyl-[protein] +
CC phosphate; Xref=Rhea:RHEA:10684, Rhea:RHEA-COMP:10136, Rhea:RHEA-
CC COMP:10137, ChEBI:CHEBI:15377, ChEBI:CHEBI:43474, ChEBI:CHEBI:46858,
CC ChEBI:CHEBI:82620; EC=3.1.3.48;
CC Evidence={ECO:0000256|ARBA:ARBA00001490};
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DR EMBL; KZ288325; PBC28040.1; -; Genomic_DNA.
DR STRING; 94128.A0A2A3E8K9; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:UniProtKB-EC.
DR GO; GO:0009653; P:anatomical structure morphogenesis; IEA:UniProt.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR GO; GO:0048666; P:neuron development; IEA:UniProt.
DR CDD; cd00063; FN3; 3.
DR CDD; cd00096; Ig; 1.
DR CDD; cd00047; PTPc; 2.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 2.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013151; Immunoglobulin.
DR InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR InterPro; IPR000242; PTP_cat.
DR InterPro; IPR016130; Tyr_Pase_AS.
DR InterPro; IPR003595; Tyr_Pase_cat.
DR InterPro; IPR000387; Tyr_Pase_dom.
DR PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR PANTHER; PTHR19134:SF495; TYROSINE-PROTEIN PHOSPHATASE 69D; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF00047; ig; 1.
DR Pfam; PF13927; Ig_3; 1.
DR Pfam; PF00102; Y_phosphatase; 2.
DR PRINTS; PR00700; PRTYPHPHTASE.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 2.
DR SMART; SM00408; IGc2; 2.
DR SMART; SM00194; PTPc; 2.
DR SMART; SM00404; PTPc_motif; 2.
DR SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 2.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 2.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 2.
DR PROSITE; PS00383; TYR_PHOSPHATASE_1; 2.
DR PROSITE; PS50056; TYR_PHOSPHATASE_2; 2.
DR PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 2.
PE 4: Predicted;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Protein phosphatase {ECO:0000256|ARBA:ARBA00022912};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 809..831
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 31..114
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 120..208
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 219..314
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 340..436
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 440..551
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 896..1153
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1073..1144
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
FT DOMAIN 1185..1442
FT /note="Tyrosine-protein phosphatase"
FT /evidence="ECO:0000259|PROSITE:PS50055"
FT DOMAIN 1359..1433
FT /note="Tyrosine specific protein phosphatases"
FT /evidence="ECO:0000259|PROSITE:PS50056"
SQ SEQUENCE 1455 AA; 165666 MW; 4D31E0E061B41D38 CRC64;
MLVRTWSRIP TEGSVNLIES IETTESKNEN PAILEITASQ DLDGIEAGST PSLICKLSVP
GQIWWTSNGK NLTTIKDFDS GGRLDIKQAS RNDTGDYKCI AQTVEGEILE KDIHIRVIEP
GRITTGEDIR VKVMESANLT CHMHGYPLSQ FSWLKGNDSE SSDHWKDFTT ITQINETLTI
LTLEFTSLTR KDNGTYICKA RDYNGEISAY RHLFVIDVPK VSIDFMKAVG AGSIFLNWTV
NDGNEPIKKY FIQHMKNGTN QYQYYSEQIG GGNSSYVLKG FESGTAYQIG ISATNNVGTS
HVRFDPRWIT TLEKGIEIHN FNHIISELLN NRSIQFVIDP IFVPKVSVNG VTENSITIAW
TVPPLDLKEH VHYYNLMITH GDQKREAVYP AQPFAVYAFV DLDPATKYKF KIAACSEYTK
ECGNWSTEVN GTTLDGVASP PQNLSVNCRF DNISSSSFIS ISWAHPEKPN GVITRYNIQL
TGIARFRNDM GRLDIDTWGP QTWSVYKKNS THFNQIPPNT NYTVRVNGVT RSRTPGKDAV
GNCTTPITVP DRDSLNMRSW RKIENQGKQL FKLYLPRITE RNGPICCYRV YLVKLAPQKS
VTDLPPPEEI NVYSYQYAHN SPSGGAYIAE IFDSDRLISE IFLGDGESFN GSNMCNKCIG
LRPKVAPPVH FVPEVSITTS VFNTTPVITT TSLTSTTTPT PTTSTVTTQR IETTITNLID
NNHTESVERK KRENMVIHKT KSEDGSFEQL LSAQDGFLDE KSNYTGFIEV IVLGNQDQLL
PAYSNYFNLL YGGLDPVTMI STEVTTLSVI LQLSIALILI IIILLIALCV LHRYTKRAQQ
RGEEIITLRN SFRHLCRSLR GRHQLVAASP PDMPPIPKSE LLQAYLERHR DSDYGFQHEF
ELLPDRFTDR TTRASEAREN LYKNRYPDIK CYDQTRVRLA QMDGICGSDY INANFVLGYK
ERKKFICAQG PMENTVCDYW RMIWEQHLEL ILMLTNLEEY SKTKCAKYWP DKGETKNFGD
ITVEHVRERA YSDYVVRELK MTRLGERDAR TIIQYHFLVW KDFMAPEHPH AILRFIKRVN
EAYSLEKGPI LVHCSAGVGR TGTLVALDSL LQQLAEEGQV SIFNTVCDLR HQRNFLVQSL
KQYIFIYRAL MEMAQYGDTE IPASQLKNNV AKLRQRDNGK EKCRMEEEYD KINSVLEDRK
SFSVGGGEEN KSKNRSELII PYDRNRVILT PVPGREHSTY INASFIEGYD NSESFVITQD
PLDTTIADFW RMISEQCIST IVMLSDLNEG PRKCPRYWPD EETAYDHIRV RYIQSESCPY
YTRREFCVSN TKTDESVVVT QYQYHGWPTV EGEVPEVTRG LIELVNQTLT NDTESSGSLV
VHCSYGSDRS SMFVALSILV QQLRTEKRVD IFTTTKKLRS QRHGMISTFA QYEFLHRAIV
NYSDLHNLAD DEPTS
//
