ID A0A2A3E9N6_APICC Unreviewed; 436 AA.
AC A0A2A3E9N6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE RecName: Full=Malate dehydrogenase, mitochondrial {ECO:0000256|ARBA:ARBA00016075};
DE EC=1.1.1.37 {ECO:0000256|ARBA:ARBA00012995};
GN ORFNames=APICC_00709 {ECO:0000313|EMBL:PBC27886.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC27886.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC27886.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC27886.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the LDH/MDH superfamily. MDH type 1 family.
CC {ECO:0000256|ARBA:ARBA00008824}.
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DR EMBL; KZ288334; PBC27886.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3E9N6; -.
DR STRING; 94128.A0A2A3E9N6; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR GO; GO:0006099; P:tricarboxylic acid cycle; IEA:UniProtKB-KW.
DR Gene3D; 3.90.110.10; Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR022383; Lactate/malate_DH_C.
DR InterPro; IPR001236; Lactate/malate_DH_N.
DR InterPro; IPR015955; Lactate_DH/Glyco_Ohase_4_C.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR PANTHER; PTHR11540; MALATE AND LACTATE DEHYDROGENASE; 1.
DR PANTHER; PTHR11540:SF16; MALATE DEHYDROGENASE, MITOCHONDRIAL; 1.
DR Pfam; PF02866; Ldh_1_C; 1.
DR Pfam; PF00056; Ldh_1_N; 1.
DR SUPFAM; SSF56327; LDH C-terminal domain-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000242457}.
FT DOMAIN 1..147
FT /note="Lactate/malate dehydrogenase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00056"
FT DOMAIN 156..313
FT /note="Lactate/malate dehydrogenase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02866"
SQ SEQUENCE 436 AA; 48467 MW; 67738BECE12D37D0 CRC64;
MKVAILGARS KTGNCLSLFL KQSPLIDELA IFDNNSSTYG LALDLNYIDT KCKVSTCNHP
EKCLEETLQG AKIVMIVTDR TSNESNEVLK SNAIILSDLL PNIIKFSPQQ LTSAMLAIVM
NPINSLIPLT MEMYKKAGIY EYNRIFGVMN FECLKANSFT ADLINIEPEC TMIPVIGGGC
SETCIPLFSQ AKPSNKISQV EARRLTYAIR MSNNNTLNPS ENKETNSFAL SYAAARFCMS
LCKALRHQGN VVECAYVRSC AIPELTYFAA PLELGPNGIQ KHLDIPPLND YECELLKAAV
PRIKKAIKLG EEKIIGKRET VFSPCTYITT YALITRAHQG SLVLNEMSMD ICNCADLNLR
ELNFLALLFL FLRLDAANFI VVLQSFVQND IIIAKLYQTV PQVCVDHVVR FRLGLGYHLR
GKNGESFIDK AEKGKS
//
