ID A0A2A3ECC7_APICC Unreviewed; 1108 AA.
AC A0A2A3ECC7;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 23.
DE SubName: Full=Semaphorin-5A {ECO:0000313|EMBL:PBC29378.1};
GN ORFNames=APICC_00148 {ECO:0000313|EMBL:PBC29378.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC29378.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC29378.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC29378.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00352}.
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DR EMBL; KZ288287; PBC29378.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3ECC7; -.
DR STRING; 94128.A0A2A3ECC7; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0030215; F:semaphorin receptor binding; IEA:InterPro.
DR GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd11265; Sema_5C; 1.
DR Gene3D; 3.30.1680.10; ligand-binding face of the semaphorins, domain 2; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR048224; Sema5C_Sema.
DR InterPro; IPR001627; Semap_dom.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR027231; Semaphorin.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR11036; SEMAPHORIN; 1.
DR PANTHER; PTHR11036:SF79; SEMAPHORIN 5C, ISOFORM A; 1.
DR Pfam; PF01403; Sema; 1.
DR Pfam; PF00090; TSP_1; 5.
DR PRINTS; PR01705; TSP1REPEAT.
DR SMART; SM00423; PSI; 1.
DR SMART; SM00630; Sema; 1.
DR SMART; SM00209; TSP1; 6.
DR SUPFAM; SSF103575; Plexin repeat; 1.
DR SUPFAM; SSF101912; Sema domain; 1.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS51004; SEMA; 1.
DR PROSITE; PS50092; TSP1; 4.
PE 4: Predicted;
KW Differentiation {ECO:0000256|ARBA:ARBA00022782};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 988..1014
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 36..485
FT /note="Sema"
FT /evidence="ECO:0000259|PROSITE:PS51004"
FT REGION 1041..1074
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1088..1108
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1094..1108
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1108 AA; 123381 MW; 44C45324BF090696 CRC64;
MGVWLTHGAE TGFGFGLRAR PKTVLAYTYA LGYDASTPHA TTPTPQYRHT SDVYTRRPSW
SRFARLTITF GQVGSRRGAA PTDNLYRLTL TSLSPLEHAS WPAPENKTNT CQNKGQSVED
CRNYVKVLLT NGKSLFTCGT YAFSPWCTWR EIENISSVTS EMSGVAMSPY SPHANVTALL
ARGPTGGLFT GAPTDFSGSD PAICRTLASP NLRTHQYDSR WLNDPQFVGS FETEDHVYFL
FRESAVEYIN CGKKIYSRIA RVCKNDRGGQ IMMREVWTTF SKARLNCSLP GEFPFYYDEI
QGAVYHPEEK IVYATFTTPI NGIAGSAICA FNMSAITASF NGPFKHQENS GAAWERRPVS
HHNRQRCGSF ANVAPHQIID NQRYQLMDDA VQSTTLEPLH TALLERFTLI ALDVTPTKLH
RSVTVLYVAT DVGLLKKISV LPRTQETCIV EVWGPLPSTP ITLQFLKDTQ SLYVGTEFGL
LRIPAAQCHR HRTRQSCLNA QEPYCGWNEH LMKCAPAPKQ NHLANHWHQE VTKCPVLTDP
VDGGWSAWSS WSPCQHGTAE HSHSHSHSHL HSEHVEAPAD ICQCQTRDCN NPPPQHGGAP
CTGARVRVTN CTVHGEWTAW SAWSACSQTC GFAMKTRRRT CTNPAPAFGG RVCVGHDHDD
NICIDLPPCP AKDEAPPPES FGQWSSWGGW NACSRPCNGG IRIRRRTCEN PSPRKSTTVE
CNGCDTQTEE CNTHSCIETK RYSGWTPWLA ANGSFQSSSM GYVEKRFRFS CRAQTDDPSS
VRVQLAKEEE RYCRNDGSCM RRNANQKSYS DLAMETGWGE WSTWKTCDRL CGGGSQHRIR
QCESPPCDGL SVQTRQCNVH SCRPSAVGDI AMEGQWSCWT DWSECSVSCG VGIRSRTREC
LGPESCEGSS LVRETCEMAS CESLIGWDTW SRWTPCDNDH QQYRKRQCLQ HGGGMCQGAS
RETRDCLPDC SGNEVNALWS MERSGITIGA VVGSCVAGFL LGLAVTAILS FFYLKRRQQR
IPGSPHYISK QNSYVTVPMK EVNTKRQPSF SGSTNGNGTL RGKNNPNVNT LGSPKLYPKS
LDYESATLKR NSHGQQHIRV DPDQDKYY
//
