ID A0A2A3EHC5_APICC Unreviewed; 1116 AA.
AC A0A2A3EHC5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 08-NOV-2023, entry version 20.
DE RecName: Full=Anion exchange protein {ECO:0000256|RuleBase:RU362035};
GN ORFNames=APICC_05420 {ECO:0000313|EMBL:PBC30692.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC30692.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC30692.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC30692.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(out) + hydrogencarbonate(in) = chloride(in) +
CC hydrogencarbonate(out); Xref=Rhea:RHEA:72363, ChEBI:CHEBI:17544,
CC ChEBI:CHEBI:17996; Evidence={ECO:0000256|ARBA:ARBA00034408};
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141, ECO:0000256|RuleBase:RU362035}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141,
CC ECO:0000256|RuleBase:RU362035}.
CC -!- SIMILARITY: Belongs to the anion exchanger (TC 2.A.31) family.
CC {ECO:0000256|ARBA:ARBA00010993, ECO:0000256|RuleBase:RU362035}.
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DR EMBL; KZ288255; PBC30692.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3EHC5; -.
DR STRING; 94128.A0A2A3EHC5; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0008509; F:monoatomic anion transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0005452; F:solute:inorganic anion antiporter activity; IEA:InterPro.
DR Gene3D; 1.10.287.570; Helical hairpin bin; 1.
DR InterPro; IPR001717; Anion_exchange.
DR InterPro; IPR013769; Band3_cytoplasmic_dom.
DR InterPro; IPR011531; HCO3_transpt-like_TM_dom.
DR InterPro; IPR003020; HCO3_transpt_euk.
DR InterPro; IPR016152; PTrfase/Anion_transptr.
DR NCBIfam; TIGR00834; ae; 1.
DR PANTHER; PTHR11453; ANION EXCHANGE PROTEIN; 1.
DR PANTHER; PTHR11453:SF47; ANION EXCHANGE PROTEIN; 1.
DR Pfam; PF07565; Band_3_cyto; 1.
DR Pfam; PF00955; HCO3_cotransp; 1.
DR PRINTS; PR00165; ANIONEXCHNGR.
DR PRINTS; PR01231; HCO3TRNSPORT.
DR SUPFAM; SSF55804; Phoshotransferase/anion transport protein; 1.
PE 3: Inferred from homology;
KW Anion exchange {ECO:0000256|ARBA:ARBA00022681};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065,
KW ECO:0000256|RuleBase:RU362035};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362035};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU362035};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU362035};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|RuleBase:RU362035}.
FT TRANSMEM 574..595
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 616..639
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 659..684
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 691..712
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 779..797
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 817..833
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 866..887
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 908..930
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 968..987
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 994..1013
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1040..1057
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT TRANSMEM 1064..1084
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU362035"
FT DOMAIN 224..483
FT /note="Band 3 cytoplasmic"
FT /evidence="ECO:0000259|Pfam:PF07565"
FT DOMAIN 545..1046
FT /note="Bicarbonate transporter-like transmembrane"
FT /evidence="ECO:0000259|Pfam:PF00955"
FT REGION 1..126
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 150..171
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1116
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 24..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 53..88
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1116 AA; 125227 MW; A30145EC997D513C CRC64;
MDNGLSPTSM QNADDETTEE MENVVSSESE APISERAASG FSDSPTVGSP RVQFEKIKEE
EVHHSFKKDE VPSVGASANH DEDRKCRRHQ KHEHKRHHHK SRKYSLQEDP QWRKRSGAGL
PDGPGVLARR VSVQPEEAST LQELDIDDLE SHRSDDPRGM RRHKAAHSTV QIGRKKEGGI
PHDTFKKMYD HSPHEVFVQL DELYGVGEER EWRETARWIK YEEDVEEGAD RWGRPHVASL
SFHSLLNLRR CLETGVVLLD LEEKDLPGLV YRVVEQMVIE ELILPEDRPV VMRALLLRHR
HVHDHDRGFR FGGKRNYASY TSLQNLNDAK PKIVSSNLAL DSNHTVVDMK EELTYTSSNE
DLKKSHNDYI LKRIPAGAEA TVVLVGAVDF LDQPTIAFVR LAEGVFIPSI TEVTIPVRFM
FTLLGPRNAD LDYHEIGRSI ATLMANTSFH KVAYKANERR ELLSAINEFL DDSIVLPPGD
WERQALLPFS ELKAKSEAIR KRKAKALEEK SKPVQSEAAV KKALLAGEEE KKAADDDDPL
RRTKRPFGGL INDIKRRYPF YLSDFTDGLS SSCLAAAIFM YFAALCTAIT FGGLMSDKTH
NVIGISETLV SGSWTGVVMA LFSTQPLVII GTTGPLLLFD ESLYNFCLAN ELEFLTVRVY
VGAWMGIIAL AIACVEGSVL VRLFTRFTEE IFTGLISILY IVETFIKLYN YFVKNPLLDE
YSFIPETNRT FYQEQPLNVT EIDVVSPKTG ETIGIPLSKP QTLIPAHNAA GILINQPNTA
LMCTILCLGT FLGAYYLRIF RNSHYLGRSA RRAFGDFGVP ISIVVFALID YLAKVKTEKL
LVPEGLTPTQ PGRNWIVSPA GVHKPIPLWM AMACIVPALL VYILVFMETQ ISELIIDKKE
RKLRKGNGYH MDIVVVCLMN VGCGLMGAPW CCAASVRSLT HVSAVTVMSR THAPGDKPHI
VEVKEQRVSA LLVAVLIGVS VLMAPLLRRV PMSVLLGVFL YMGISSTNGV QLFDRVKLFF
MPVKHHGTAN YVRRVQTYKM HIFTLIQILC LAILWIVKST RAALALPFFL ILMIPLRGQM
NHFFTAAELR ALDSKGSEHE STEDEPDFYE EAPLPG
//
