ID A0A2A3EHI4_APICC Unreviewed; 836 AA.
AC A0A2A3EHI4;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Fibrillin-2 {ECO:0000313|EMBL:PBC31263.1};
GN ORFNames=APICC_05959 {ECO:0000313|EMBL:PBC31263.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC31263.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC31263.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC31263.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular
CC matrix {ECO:0000256|ARBA:ARBA00004498}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR EMBL; KZ288241; PBC31263.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3EHI4; -.
DR STRING; 94128.A0A2A3EHI4; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR CDD; cd00054; EGF_CA; 9.
DR Gene3D; 2.10.25.10; Laminin; 12.
DR Gene3D; 3.90.290.10; TGF-beta binding (TB) domain; 3.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR009030; Growth_fac_rcpt_cys_sf.
DR InterPro; IPR017878; TB_dom.
DR InterPro; IPR036773; TB_dom_sf.
DR PANTHER; PTHR24040:SF13; FIBROPELLIN-1; 1.
DR PANTHER; PTHR24040; LAMININ G-LIKE DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF07645; EGF_CA; 10.
DR Pfam; PF00683; TB; 3.
DR SMART; SM00181; EGF; 12.
DR SMART; SM00179; EGF_CA; 10.
DR SUPFAM; SSF57196; EGF/Laminin; 2.
DR SUPFAM; SSF57184; Growth factor receptor domain; 2.
DR SUPFAM; SSF57581; TB module/8-cys domain; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 9.
DR PROSITE; PS00022; EGF_1; 1.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 10.
DR PROSITE; PS01187; EGF_CA; 4.
DR PROSITE; PS51364; TB; 3.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Extracellular matrix {ECO:0000256|ARBA:ARBA00022530};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..16
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 17..836
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012291152"
FT DOMAIN 175..207
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 213..256
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 273..309
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 315..355
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 360..414
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 423..462
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 463..502
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 503..543
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 544..581
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 586..626
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 627..666
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 671..727
FT /note="TB"
FT /evidence="ECO:0000259|PROSITE:PS51364"
FT DOMAIN 739..780
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 179..189
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 197..206
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 467..477
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 631..641
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 836 AA; 91266 MW; 231BB6FB33E472C3 CRC64;
MAFILAIWLL TTIARGVTST GQRYTTSPAQ DLDNTLQSVP PLGPNVCRSR YKNYCCPGWT
KKPETGLCVI PICVRRCGPL GRCIRPNICL CEGGTVASSC TSSQTKATPT YETGNALDRG
ESGRCRVHCI NGNCVDGKCQ CRSGYQGEFC NERELSTFNI LIPPPSFDVP IRLFKIAICR
EPCLNQGRCI GPDRCACIYG YTGRRCETDY RTGPCYTKVK NGQCLANLQG VVCTRQLCCA
TVGKGWGHPC ERCPSRLDCE LGHLKTNQGQ CVDINECEAI PGLCEGGKCV NTPGSFTCEC
PDGQARDPET NSCKDKDECQ EEGICTDGRC INTNGGYYCL CNPGFIQSQD RRFCIDGRQG
LCYTSVNRNG QCKNRLAMRL SKKDCCCGKN MGRGWGDECY ICPNPGSDDY NRLCLQQLQP
ITEINECALR PDICGNGKCI DTKDGYECDC YNGFTKKGNR CEDIDECLLG YCQGGTCRNY
EGSFSCQCPP GFVVSGEGRY CTDHDECQDT GMCNNGHCIN MNGSFKCKCN DGYVLSPTKN
TCIDINECAE NPRICLNGRC ENTPGSYHCI CQPGFTPSRD NTFCVDMDEC STSGMCENGK
CVNMEGSFKC VCDSGFRIGP DQSHCIDIDE CLSAPCQNGR CINTPGSFRC ECNPGFNLGP
DGRSCLETRR DLCYSQYRDG QCSNPTSTAV TKSSCCCCTV ILGQPMGWGT PCQPCPLPNT
NEFDALCPHG AGMTYSGDDI NECAQNPNIC VNGGCENLMG TYRCICDSGY EVDATGKICS
DINECELEQS LCSGGQCRNT PGSFQASKVP RVSNRRHLRL DLAAKLEELA VTNRDV
//
