ID A0A2A3EII2_APICC Unreviewed; 1091 AA.
AC A0A2A3EII2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Active breakpoint cluster region-related protein {ECO:0000313|EMBL:PBC31520.1};
GN ORFNames=APICC_07123 {ECO:0000313|EMBL:PBC31520.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC31520.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC31520.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC31520.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KZ288232; PBC31520.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3EII2; -.
DR STRING; 94128.A0A2A3EII2; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd13368; PH_BCR_arthropod; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 4.10.280.30; Bcr-Abl oncoprotein oligomerisation domain; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR037769; Abr/Bcr.
DR InterPro; IPR036481; Bcr-Abl_oncoprot_oligo_sf.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR23182; BREAKPOINT CLUSTER REGION PROTEIN BCR; 1.
DR PANTHER; PTHR23182:SF1; RHO GTPASE ACTIVATING PROTEIN AT 1A, ISOFORM E; 1.
DR Pfam; PF19057; PH_19; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000242457}.
FT DOMAIN 342..531
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT DOMAIN 546..707
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 885..1073
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 142..218
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..267
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 300..339
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 147..162
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 180..197
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 198..218
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 300..325
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1091 AA; 123129 MW; 5E6B71B3E8D74997 CRC64;
MSVFGDFQRV WVQRFPDSAL PAAWEEDVRA NLVKHKQKVT ALREELEKEE FYVEYLERLL
ADVERHKQLA NSNIITSPDK QQPIESQNQH SCQAAENNLT NSTSTSHIQH VESSISSLPA
SEDISKFQDK CVTELSSTLN TCKRPKSEIP RCPDKVPELR RNSDPDVPSN YVTVIEVTGS
SKKDKNEESL KEEDEKDLEN AINEDGEDGD AEVSEEEPYY DSVALDQTGE YVYIDARVPP
VGNNNGSRAP PRRPPSLPDS PGNQSNYVNI DYFIQHRVAD SEDEEGASPA PILLRALSTD
NETGSSDAEP LSLSEGSLES PTPTTPRRQE KSKEREDDRT SMIKCIVNSV VESETIYVEC
LNVMLQYMKA IRATLTTSQP VISEDEFGTM FYKIPELHAL HQTFLDGLRK KLEKWDIKTT
IGEQFKVMAS NIGLYGAFLH NYARATDTVR RCSAHSTQFG EITRDIRLRG FPKGPGLSLE
DLLHKPVARV QKNALVLHDL LKHTPVNHAD HAPLSEALAM TRNFLDEFNI IQTKSMFPSH
DRAQRRLVKN SFVVELSDGH RKLRHLFLFN DVIACAKYKA SGRDKFTFEL KWYVPVAEAA
VTEDGVEPRE TSPANVVALR SQACTVRDQI LWEERNDEKR IRLGGRGSEK NRKKLAELEA
QLVLASPNLV LRVAHKSQHR VQNSYTFFLS SEFERSQWVE AVEALQQGGQ PPGPLPLSMY
ELQAWVTACR TYLQTDMGSY LLRSGRDESL LLGDLHLTLL GLTPPGLDRV GDLYIIVEVD
SYGHYFKRAR SRVARGQAPT WGETFVVELE GSQNVRILLY EECGTRSVLR GKCIQRLSRS
WLQSDQIERS LNLGPATLDV ALRFVPSEVT LRRVPSAKPQ GLFGAKIQQV CKREKRDVPF
IITACVREVE RRGVGEVGLY RVSGSASDLT KLRKSFESNS YEAEQLLKEI YYLYKVDVHS
VTGVLKLYLR EMPEALFTDA LYPAFLEAFQ TGELSKGAAL RRVYESLPAV NKAVIDFLLA
HLIRVNKHEA QNKMSLHNLA TVFGPTLLRP DAYATEQSVT LVERFLLIHR SVSCFLRVSL
EIELAATYAV M
//
