ID A0A2A3EJY3_APICC Unreviewed; 745 AA.
AC A0A2A3EJY3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE SubName: Full=Inhibitor of nuclear factor kappa-B kinase subunit epsilon {ECO:0000313|EMBL:PBC32008.1};
GN ORFNames=APICC_04832 {ECO:0000313|EMBL:PBC32008.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC32008.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC32008.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC32008.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KZ288223; PBC32008.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3EJY3; -.
DR STRING; 94128.A0A2A3EJY3; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0004674; F:protein serine/threonine kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProt.
DR CDD; cd12219; Ubl_TBK1_like; 1.
DR Gene3D; 1.20.1270.420; -; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR017441; Protein_kinase_ATP_BS.
DR InterPro; IPR041309; TBK1_CCD1.
DR InterPro; IPR041087; TBK1_ULD.
DR PANTHER; PTHR22969:SF15; FI05319P; 1.
DR PANTHER; PTHR22969; IKB KINASE; 1.
DR Pfam; PF00069; Pkinase; 1.
DR Pfam; PF18394; TBK1_CCD1; 1.
DR Pfam; PF18396; TBK1_ULD; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00107; PROTEIN_KINASE_ATP; 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU10141};
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:PBC32008.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU10141}; Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Serine/threonine-protein kinase {ECO:0000256|ARBA:ARBA00022527};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 12..317
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT BINDING 41
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU10141"
SQ SEQUENCE 745 AA; 84961 MW; ADD41DFCEE6C1DE0 CRC64;
MSFLRGSTNF VWCTTSVLGK GATGAVFQGV NKNNGEPVAV KTFNQLSHMR PHDVQMREFE
VLKKVNHENI VQLLAIEEEQ DGRGTVIVME LCTGGSLFNI LDDPENTYGL AESEFLLVLE
HLTAGMKHLR DNNLVHRDLK PGNIMKFIAD DGSTIYKLTD FGAARELQED QQFVSLYGTE
EYLHPDIYER AVLRKPVGKT FGATVDLWSI GVTLYHVATG NLPFRPFGGR RNKETMFYII
TKKASGVISG VQTSENGPIE WSRELPQNCQ LSTGLKKIVT PLLAGLLEVD PQKIWSFERF
FSEVTDTLCR KRIHIFNIHK GSLIKVFLHP EEKLTALQVH IQDQTDIAPH AQILLFGDTF
LTNIIEESTS GKGYPNTSEN KPLMLFSKEN NNVDLPVDTE LPKFPVFANL VSVENDASQA
KVACSVGYVC KRRIDKLVLC SKLSQDAIEA FSGLVSTELT RLLEKCQHSK EFTKAVEDTT
IAIERSENLA WQVSRKLGRQ NTLEIKNWKK ELDMKSKELL TELAPAVVQL HQRYVKEGSL
RGEWDNIIRG LWCPWFNKAS QKAATLVDRL RDGWQHLLRD RATRGLTYND EQFHVLERIK
VTSTGQRIKN LLETFCIPSM ISRSECVADW YKMAQTVFLQ TQILDKDVDN YEHILEAFSY
RLSHESKERY ENFVHLIDRF PEKLKTIEKT NSPAQESTKK WKNICVMQEQ IAMILYKNGL
LIDQLDRLST LDTLEDTDDS EYTSL
//
