ID A0A2A3ELW8_APICC Unreviewed; 809 AA.
AC A0A2A3ELW8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Metabotropic glutamate receptor {ECO:0000313|EMBL:PBC32700.1};
GN ORFNames=APICC_08905 {ECO:0000313|EMBL:PBC32700.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC32700.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC32700.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC32700.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; KZ288215; PBC32700.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3ELW8; -.
DR STRING; 94128.A0A2A3ELW8; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:InterPro.
DR CDD; cd15934; 7tmC_mGluRs_group2_3; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF158; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 2.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR01176; GABABRECEPTR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00980; G_PROTEIN_RECEP_F3_2; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000313|EMBL:PBC32700.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..32
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 33..809
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012426542"
FT TRANSMEM 480..504
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 519..541
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 547..566
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 587..614
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 640..659
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 671..691
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 703..730
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 481..745
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 809 AA; 89694 MW; 1CBF1ED374F65310 CRC64;
MSQRPLARML VLLVSLHRLS IYGGSHWRPG RSESVVIPGD IVLGGITIGV HILDTCGRDT
YALNQSLHFV RASLSNLDMS VLECADRSAP RVKKTASAGP IFGVIGGSYS SVSLQVANLL
RLFHIPQISP ASTAKALSDK TRFDYFARTV PPDTFQSIAL VDVVKSANWS YVSTVYSEGS
YGEYGIEVFT REATERNVCI AAAVKVPSAA DDRMFDDIIQ RLSKKANARA RRWGRQIKLV
EGLEEEAEGA ITVELQSENI PGFDDYMASL TPDTNRRNPW FSEYWEEVFD CLLKKERKGP
IQTTLNATTL FCPPNLRLTS ERGYEQESKV QFVVDAVYAF ALALHNLQRD VCSKLEGLCP
SMANYDRGVF YRNYLLNVSF TGKNFVVGKW FNSLDIRTEE LVWARGTKDI PISACSLPCE
PGMIKKQQGD TCCWVCDQCE EYEYVHDEYT CMDCGPGKWP HEDKRGCYQL AINHIRWNSA
FAIAPAVISC LGIVATMAVA CLLFHHRDTP VVRASGRELT IILLAGVLVC YLNTFLLLAT
PTTVTCILQR FGVGVSFSAV YGALLTKTNR IARIFDSASR TAVRPRYISP ASQVCIAAAL
IALQIVLTLV WMIIEPPGTR FFYPDRKQVI LKCNIQDMSF LFSQLYNALL ILISTVYAVK
TRKIPENFNE SKFIGFTMYT TCIIWLAFVP IYFGTGNAHE TQITTLCVAI SLSATVTLVC
LYSPKIYIIL FQPDKNIRRK VTMGDKSKKQ GSSAGTSSIT KYTGCELTSE SMPLQSALTA
AVQTSVGVTE ISLASNASSK TNNEQVAQL
//
