ID A0A2A3EQP6_APICC Unreviewed; 2032 AA.
AC A0A2A3EQP6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Protein still life, isoform SIF type {ECO:0000313|EMBL:PBC34058.1};
GN ORFNames=APICC_02140 {ECO:0000313|EMBL:PBC34058.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC34058.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC34058.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC34058.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
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DR EMBL; KZ288193; PBC34058.1; -; Genomic_DNA.
DR STRING; 94128.A0A2A3EQP6; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00992; PDZ_signaling; 1.
DR CDD; cd01230; PH1_Tiam1_2; 1.
DR CDD; cd01255; PH2_Tiam1_2; 1.
DR CDD; cd00160; RhoGEF; 1.
DR Gene3D; 2.30.42.10; -; 1.
DR Gene3D; 6.10.140.680; -; 1.
DR Gene3D; 1.20.900.10; Dbl homology (DH) domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 3.
DR InterPro; IPR035899; DBL_dom_sf.
DR InterPro; IPR000219; DH-domain.
DR InterPro; IPR001331; GDS_CDC24_CS.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR003116; RBD_dom.
DR InterPro; IPR043537; Tiam1/Tiam2/Sif.
DR InterPro; IPR040655; TIAM1_CC-Ex.
DR InterPro; IPR000697; WH1/EVH1_dom.
DR PANTHER; PTHR46001:SF2; PROTEIN STILL LIFE, ISOFORM SIF TYPE 1; 1.
DR PANTHER; PTHR46001; TIAM (MAMMALIAN TUMOR INVASION AND METASTASIS FACTOR) HOMOLOG; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF02196; RBD; 1.
DR Pfam; PF00621; RhoGEF; 1.
DR Pfam; PF18385; Tiam_CC_Ex; 1.
DR SMART; SM00228; PDZ; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00455; RBD; 1.
DR SMART; SM00325; RhoGEF; 1.
DR SMART; SM00461; WH1; 1.
DR SUPFAM; SSF48065; DBL homology domain (DH-domain); 1.
DR SUPFAM; SSF50156; PDZ domain-like; 1.
DR SUPFAM; SSF50729; PH domain-like; 3.
DR PROSITE; PS00741; DH_1; 1.
DR PROSITE; PS50010; DH_2; 1.
DR PROSITE; PS50106; PDZ; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50898; RBD; 1.
DR PROSITE; PS50229; WH1; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000242457}.
FT DOMAIN 46..164
FT /note="WH1"
FT /evidence="ECO:0000259|PROSITE:PS50229"
FT DOMAIN 850..963
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 1128..1195
FT /note="RBD"
FT /evidence="ECO:0000259|PROSITE:PS50898"
FT DOMAIN 1211..1287
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 1423..1617
FT /note="DH"
FT /evidence="ECO:0000259|PROSITE:PS50010"
FT REGION 172..205
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 261..363
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 623..664
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 708..780
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1101..1123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1390..1412
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1789..1918
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1984..2010
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 188..205
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 288..309
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 322..356
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 623..647
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 648..664
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 708..730
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 743..759
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 760..780
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1105..1119
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1391..1412
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1789..1804
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1814..1856
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1857..1876
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1877..1895
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1896..1918
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1991..2010
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2032 AA; 228755 MW; 7FC4814A3620C90F CRC64;
MGNKLSCSCA PLIRKAYRYE DSPWQAGARG GMGGSGARRG DTGHLLRCGS LRERKRLWAE
VFHVSASGAG TVKWQQVSED LVPVNITCIQ DSPECIFHIT AYNSQVDKIL DVRLVQPGTR
IGQASECFVY WKDTMTNDTW GLNFTSPIDA KQFRECCSPS FKISRKASSS YSLKLEPPNK
QKIKTRRKPL STPASPSRSR EPQCTCMTPE QLARFRSQEA RYRGFCTTST LPRTMARSTE
VEMTPGRDKI TAATSSASLY DNVNNANVTP GKTAKAGESK QKEKQNETCQ TTPKTANVGI
ETVTVGSQID SPEEKGAAIS PKKGQKQSQD SSTQQNGSEM LKSEGTQAGG TLQNKSLRKE
QLHHTKSADY TDLEMQNGNI FNIVNNNHSG KKSKSKSTDD MRIENAQNGG ISLDSNTLKR
MLKPMPSIDS PVTSPEMTRK RHSHHNYHYH PSNNNQKYIM QETENENCAH LYRPTYNNKF
QTTRSVHDMG RQYAGGRART YLDSERNRCT GDMSPPSDNV IFDNQCYATT PSSSNGNSDM
EQPTHCNSRR CNGSQVYQQQ NMQSVSTPGS PTSRLLLEYE MHLRNTLAKG MDAESYSLRT
FEALLTQSME DLEFAKNIPL NTQRTPHVSR RRSSSNKSST LPLSYRYERQ NSKDRDGYYS
DRNEMIREKR DREIDRDRGY LSDYNSRCTS CVGESARAQW FRHSDGWQSG SSTLGSGASS
SINPSYTGHK RDSPWDSLPS LRHEGSLNDS GYKSNRTDSL EQRGTFDRQD SVRSDYMSDR
DGRYGIVQQA SLESTDSRIC YLTSSEMSDD DKMSLTTAVS DDDDGESVIN SPYRGKQTGT
AAASFNCTGA VRKAGFLSVK KWLLRKKHQI ELARKRGWKG YWVCLKGTTL LFYPCESQES
RTMEAAPKHL IIVDGAIMQP IPEHPKRDYI FCLSTAFGDA YLFQAPCQVE LENWVNSIHS
ACAAAFARHR GKTGTLHLLQ EEIFRLEKAI ESDHKLKHMA DLQQSVVSDV ETKQQINNQI
VQWEENLERL HCEQFRLRCY MASLQSGELP NPKSLLTHVS RATKQTLNKL GVFTVSSFHA
FICARSPSLL NNLLAGRGAT KRRPPLLSRS NSGSSRRSLQ ISSRDDEKTV KVFVPENQLV
SVFVRDAMTV EEFLASACNR KNLNPMEHFV RVKKRRDMED HNYFVPHRTD LIETYLHTHE
VVEVCAKILY QVELQRNTLE QMWGFSVEAE LIENSDRQDE LCCYVSRVED KSVAMQNGII
KGDEIMVING AIVSDLDMMY LESVLQEEVG LCMMMRSSRT EPPDLTGIMR VTDDIIESLV
CPPPPSDPPV ISEEMISGLI VPAPGWSKES IMQECTTTSH MENGKQTSRT NSFEIENLLK
TAEQVTGICR SPGETRKSSP TGSVVSSHSQ ALTPSRQLSD AEKLKKVILE LIETERTYVK
NLNNLLENYL EPLKRETFLS NAEINALFGN IQEIVTFQRQ FLQNLDHAIE MEADFNNFDH
PSQFKGVLFS IGSAFLYYVN HFKLYSSFCA SHSKAQKVLH PNEGNQALQE FLQARNPRQQ
HSSTLESYLI KPIQRILKYP LLLQQLRNLT DERSEEHQHL IEALKGMEKV AEHINEMQRI
HEEYGAIFDH LFRQHQKSCK QPIDLSPGDL LYYGGVEWLN ISDFLGKIKK GLELHAMCFV
FKSAVVFLCK ERLRQKKKLM GVSTKANSSE VEIIRYQVLI PVTEVQVRAS SAKDMESHFL
WELIHLRSQL QRRSEKVYVL SNSTTEFRNA FLRTIRQIIR ESVRNMSIPS TKQNLSQPPI
SISPRMSTGH VEKFEKQSAG TSQVGQNGGN GGSGVATLSK KKQQLLTTSH NVKRKYSQSK
QAVEHESSED KDNEEAGASA INQQQTTFRS RSKTISDTSG EIKVEMDSGT KSEGEEDSQA
FLGEKKANLG RTPNHLTLST TSTISAGSTG SQARLIQSSH QPENYQPITV KELGSPIWKP
RELPSLGEST TLPRKGKSAS EFGDISSSHS ASRKSLIEIN NCAQQSNCNN HV
//
