ID   A0A2A3EST4_APICC        Unreviewed;       604 AA.
AC   A0A2A3EST4;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   13-SEP-2023, entry version 18.
DE   SubName: Full=SH2B adapter protein {ECO:0000313|EMBL:PBC34199.1};
GN   ORFNames=APICC_03130 {ECO:0000313|EMBL:PBC34199.1};
OS   Apis cerana cerana (Oriental honeybee).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC   Anthophila; Apidae; Apis.
OX   NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC34199.1, ECO:0000313|Proteomes:UP000242457};
RN   [1] {ECO:0000313|EMBL:PBC34199.1, ECO:0000313|Proteomes:UP000242457}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC34199.1};
RA   Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA   Wu J.;
RT   "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT   insights into honey bee biology.";
RL   Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the SH2B adapter family.
CC       {ECO:0000256|ARBA:ARBA00010220}.
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DR   EMBL; KZ288192; PBC34199.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A3EST4; -.
DR   STRING; 94128.A0A2A3EST4; -.
DR   Proteomes; UP000242457; Unassembled WGS sequence.
DR   GO; GO:0035591; F:signaling adaptor activity; IEA:InterPro.
DR   GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR   CDD; cd01231; PH_SH2B_family; 1.
DR   CDD; cd10346; SH2_SH2B_family; 1.
DR   Gene3D; 6.10.140.110; -; 1.
DR   Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR   Gene3D; 3.30.505.10; SH2 domain; 1.
DR   InterPro; IPR011993; PH-like_dom_sf.
DR   InterPro; IPR001849; PH_domain.
DR   InterPro; IPR015012; Phe_ZIP.
DR   InterPro; IPR036290; Phe_ZIP_sf.
DR   InterPro; IPR000980; SH2.
DR   InterPro; IPR036860; SH2_dom_sf.
DR   InterPro; IPR030523; SH2B.
DR   InterPro; IPR035057; SH2B1_SH2.
DR   PANTHER; PTHR10872:SF2; LNK, ISOFORM D; 1.
DR   PANTHER; PTHR10872; SH2B ADAPTER PROTEIN; 1.
DR   Pfam; PF00169; PH; 1.
DR   Pfam; PF08916; Phe_ZIP; 1.
DR   Pfam; PF00017; SH2; 1.
DR   PRINTS; PR00401; SH2DOMAIN.
DR   SMART; SM00252; SH2; 1.
DR   SUPFAM; SSF50729; PH domain-like; 1.
DR   SUPFAM; SSF109805; Phenylalanine zipper; 1.
DR   SUPFAM; SSF55550; SH2 domain; 1.
DR   PROSITE; PS50003; PH_DOMAIN; 1.
DR   PROSITE; PS50001; SH2; 1.
PE   3: Inferred from homology;
KW   Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW   SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW   ProRule:PRU00191}.
FT   DOMAIN          218..324
FT                   /note="PH"
FT                   /evidence="ECO:0000259|PROSITE:PS50003"
FT   DOMAIN          427..525
FT                   /note="SH2"
FT                   /evidence="ECO:0000259|PROSITE:PS50001"
FT   REGION          188..209
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          351..389
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          538..604
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        188..203
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        354..368
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        576..604
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   604 AA;  67429 MW;  F3A516F57A1E9529 CRC64;
     MSVYTITAAT PTTSTIISTT TATTTTAVTV TTTATPTTTA PAVAVSPEAA PGWIEFCERH
     ARASASDFAK AFCTYVSLNL PESARLNLSH HDFLKKFVES FCEHFENEYL RRTVRSPSLY
     DTRHSATNDR DINAISQNNN APIRISSHEE FSDYSEHDGD AISPKPSHKP FFRRLSFKGL
     KKGKSLFHKQ QSDEVELSHS EHRRDKHSKA KLSKIVVECR KEGIVNSLMG ENIDGTQKWE
     KSRLALIKAI GGYMLEFYSP PKAVKPRSGV FCSAITEARE TTALEMPDHE NTFVLKTQNM
     EFVIEAHDSN DMRSWLATIK YCMRTVQQNS INPNSGVEAT GESLGHASLA ISNEGDRLRT
     NSASKSSRST SHEHGDEIGG NPPEIPPRLR IRSNSNLELC SSQQDIEQLN VNDGELDLSS
     SLREYPWFHG TLPRSDAAQL VLHSAANGHG VFLVRQSETR KGEFVLTFNF QGRAKHLRMT
     LNDQGHCRVQ HLCFPAIYDM LEHFRQNAIP LESGGTADVT LTEFVVANHA IRSAHHNMSG
     INQQQLQERR PPVAPEPREV RTYGGSIRTR TESLERLEQQ NTITEQQSSS STSGRAIQNT
     YSFL
//