ID A0A2A3EUQ5_APICC Unreviewed; 957 AA.
AC A0A2A3EUQ5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Coatomer subunit beta {ECO:0000256|ARBA:ARBA00017024, ECO:0000256|PIRNR:PIRNR005727};
DE AltName: Full=Beta-coat protein {ECO:0000256|ARBA:ARBA00030841, ECO:0000256|PIRNR:PIRNR005727};
GN ORFNames=APICC_01238 {ECO:0000313|EMBL:PBC34791.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC34791.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC34791.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC34791.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: The coatomer is a cytosolic protein complex that binds to
CC dilysine motifs and reversibly associates with Golgi non-clathrin-
CC coated vesicles, which further mediate biosynthetic protein transport
CC from the ER, via the Golgi up to the trans Golgi network. Coatomer
CC complex is required for budding from Golgi membranes, and is essential
CC for the retrograde Golgi-to-ER transport of dilysine-tagged proteins.
CC {ECO:0000256|PIRNR:PIRNR005727}.
CC -!- SUBUNIT: Oligomeric complex that consists of at least the alpha, beta,
CC beta', gamma, delta, epsilon and zeta subunits.
CC {ECO:0000256|PIRNR:PIRNR005727}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR005727}. Golgi
CC apparatus membrane {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR005727}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004255, ECO:0000256|PIRNR:PIRNR005727};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004255,
CC ECO:0000256|PIRNR:PIRNR005727}. Cytoplasmic vesicle, COPI-coated
CC vesicle membrane {ECO:0000256|PIRNR:PIRNR005727}; Peripheral membrane
CC protein {ECO:0000256|PIRNR:PIRNR005727}; Cytoplasmic side
CC {ECO:0000256|PIRNR:PIRNR005727}. Membrane
CC {ECO:0000256|ARBA:ARBA00004287}; Peripheral membrane protein
CC {ECO:0000256|ARBA:ARBA00004287}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004287}.
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DR EMBL; KZ288186; PBC34791.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3EUQ5; -.
DR STRING; 94128.A0A2A3EUQ5; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0030126; C:COPI vesicle coat; IEA:InterPro.
DR GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005198; F:structural molecule activity; IEA:InterPro.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:UniProtKB-KW.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR002553; Clathrin/coatomer_adapt-like_N.
DR InterPro; IPR011710; Coatomer_bsu_C.
DR InterPro; IPR016460; COPB1.
DR InterPro; IPR029446; COPB1_appendage_platform_dom.
DR PANTHER; PTHR10635; COATOMER SUBUNIT BETA; 1.
DR PANTHER; PTHR10635:SF0; COATOMER SUBUNIT BETA; 1.
DR Pfam; PF01602; Adaptin_N; 1.
DR Pfam; PF07718; Coatamer_beta_C; 1.
DR Pfam; PF14806; Coatomer_b_Cpla; 1.
DR PIRSF; PIRSF005727; Coatomer_beta_subunit; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|PIRNR:PIRNR005727};
KW Cytoplasmic vesicle {ECO:0000256|PIRNR:PIRNR005727};
KW ER-Golgi transport {ECO:0000256|ARBA:ARBA00022892,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Golgi apparatus {ECO:0000256|ARBA:ARBA00023034,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|PIRNR:PIRNR005727};
KW Protein transport {ECO:0000256|ARBA:ARBA00022927,
KW ECO:0000256|PIRNR:PIRNR005727};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|PIRNR:PIRNR005727}.
FT DOMAIN 24..525
FT /note="Clathrin/coatomer adaptor adaptin-like N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01602"
FT DOMAIN 665..805
FT /note="Coatomer beta subunit C-terminal"
FT /evidence="ECO:0000259|Pfam:PF07718"
FT DOMAIN 812..942
FT /note="Coatomer beta subunit appendage platform"
FT /evidence="ECO:0000259|Pfam:PF14806"
SQ SEQUENCE 957 AA; 105688 MW; 3859DA716785DB15 CRC64;
MSTIAEQPCY TLINVPTDTE PLNELQLKQD LEKGDVHTKI EALKKTIHTI LSGERLPGLL
MTIIRFVLPL QDHTIKKLLL IFWEIVPKTS PDGKLLQEMI LVCDAYRKDL QHPNEFVRGS
TLRFLCKLKE PELLEPLMPA IIACLEHRHS YVRRNAVLAI FTIYRNFEFL IPDAPELIAK
YLEGEQDMSC RRNAFLMLLH ADQSRALAYL AACLDQVPNF GDILQLVIVE LIYKVCLANP
SERARFIRCI YSLLNSPSAA VRYEAAGTLV TLSNAPTAIK AAASCYIELV VKESDNNVKL
IVLDRLIAMK DSPVYERVLQ DLVMDVLRVL GSPALEVRTK TLALAMDLVT TRTIDEMVQL
LKKEVLRTAG GEHEDAGRYR QLLVRTLHAC SIKFSDVAAT VIPVLTDFLS ENNEAAATDV
LVFVREAIQR FENLRPLIVE KLLEVFPHIR SVRVHRAALW ILGEYANTKE DIEAVMSRIR
AALGELPLLE AENKRQAGEK LDDGSAQVTP AQLVTSDGTY ATQSAFSATS ARKKEEKRPA
LVQYMMEGDF FIGASLATTL SKLALRYKSL ETDLQKSNHM QAEAMLIMSS VMQLGRSGLP
TKAITHDDAE RLSLCLRSLA CPTSLVQKVF TEGCRDALGR MLAAKAEEDS QNQKAKEKPG
NIVQVDDPIQ FLQLSRGSDL TGGAGDVFEQ SLSAAVAGRP GASGDAPAPS ALSKVTQLTG
FSDPVYAEAL VHVNQYDIVL DVLIVNQTED TLQNCTLELA TMGDLKLVER PQPIVLAPRD
FASIKANVKV ASTENGIIFG NIVYDVSGAG SDRSVVVLND IHIDIMDYIV PATCTDLEFR
QMWAEFEWEN KVSVNTTLSD LREYLAHLLK STNMRCLTPE KALSGQCGFM AANMYAKSIF
GEDALANMSI EKPLNKPDAP VVGHIRIRAK SQGMALSLGD KISSTQKGPQ SKVVQAA
//
