ID A0A2A3EUR1_APICC Unreviewed; 623 AA.
AC A0A2A3EUR1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Xaa-Pro aminopeptidase {ECO:0000313|EMBL:PBC34879.1};
GN ORFNames=APICC_03131 {ECO:0000313|EMBL:PBC34879.1};
OS Apis cerana cerana (Oriental honeybee).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Apoidea;
OC Anthophila; Apidae; Apis.
OX NCBI_TaxID=94128 {ECO:0000313|EMBL:PBC34879.1, ECO:0000313|Proteomes:UP000242457};
RN [1] {ECO:0000313|EMBL:PBC34879.1, ECO:0000313|Proteomes:UP000242457}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC TISSUE=Pupae without intestine {ECO:0000313|EMBL:PBC34879.1};
RA Diao Q., Sun L., Zheng H., Zheng H., Xu S., Wang S., Zeng Z., Hu F., Su S.,
RA Wu J.;
RT "Genomic and transcriptomic analysis on Apis cerana provide comprehensive
RT insights into honey bee biology.";
RL Submitted (JUL-2014) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase M24B family.
CC {ECO:0000256|ARBA:ARBA00008766, ECO:0000256|RuleBase:RU000590}.
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DR EMBL; KZ288185; PBC34879.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3EUR1; -.
DR STRING; 94128.A0A2A3EUR1; -.
DR Proteomes; UP000242457; Unassembled WGS sequence.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0070006; F:metalloaminopeptidase activity; IEA:InterPro.
DR CDD; cd01085; APP; 1.
DR Gene3D; 3.90.230.10; Creatinase/methionine aminopeptidase superfamily; 1.
DR Gene3D; 3.40.350.10; Creatinase/prolidase N-terminal domain; 2.
DR InterPro; IPR029149; Creatin/AminoP/Spt16_NTD.
DR InterPro; IPR036005; Creatinase/aminopeptidase-like.
DR InterPro; IPR000587; Creatinase_N.
DR InterPro; IPR000994; Pept_M24.
DR InterPro; IPR033740; Pept_M24B.
DR InterPro; IPR032416; Peptidase_M24_C.
DR InterPro; IPR001131; Peptidase_M24B_aminopep-P_CS.
DR PANTHER; PTHR43763; XAA-PRO AMINOPEPTIDASE 1; 1.
DR PANTHER; PTHR43763:SF6; XAA-PRO AMINOPEPTIDASE 1; 1.
DR Pfam; PF01321; Creatinase_N; 1.
DR Pfam; PF16189; Creatinase_N_2; 1.
DR Pfam; PF00557; Peptidase_M24; 1.
DR Pfam; PF16188; Peptidase_M24_C; 1.
DR SUPFAM; SSF55920; Creatinase/aminopeptidase; 1.
DR SUPFAM; SSF53092; Creatinase/prolidase N-terminal domain; 1.
DR PROSITE; PS00491; PROLINE_PEPTIDASE; 1.
PE 3: Inferred from homology;
KW Aminopeptidase {ECO:0000313|EMBL:PBC34879.1};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU000590}; Protease {ECO:0000313|EMBL:PBC34879.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000242457}.
FT DOMAIN 25..133
FT /note="Creatinase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF01321"
FT DOMAIN 328..544
FT /note="Peptidase M24"
FT /evidence="ECO:0000259|Pfam:PF00557"
FT DOMAIN 557..621
FT /note="Peptidase M24 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF16188"
SQ SEQUENCE 623 AA; 70232 MW; 3EC5D4EAC106585C CRC64;
MAQRSGIIKL AKLRELMKAV QIGGLKEKGI QALIVSSDDA HQSEYLREHD KRICFISGFT
GSFGTAIITQ NKALLWTDGR YYMQALAEFD PPEEWTLMKE GLLDTPTRAA WLTCNLPPKS
TVGADSNLIS YTEWVVLHTS LTAAGHCLMP LEENLIDKVW GDEQPAPTAN IIVPQSLQFS
GCIAGKKVKL CREVMNKNKV KALVITALDE IAYILNLRGS DIPYNPVFFA YIILTLDHLH
LFIDTSKLTE EAQQQLIIEE INLIYHPYED IHNCLKKIAN LCINDDKIWL SNSSSYALHA
DCGEAKKHIK ITPISVMKAV KNNTEIAGMK AAHVRDSVAL VKYFAWLEDQ IKNKKNTVTE
ISGAAQLEKF RQEQEHFIGL SFPTISSVGP HAAIIHYLPT LKTDVPITDK EIYLCDSGAQ
YQDGTTDVTR TLHFGNPTNF ERECFTRVFK GQCRLSSTIF PLMIQGNYLD TLARENLWNV
GLNYLHGTGH GIGSYLNVHE GPISISWRPY PDDPGLQPGM FLSNEPGYYE DEKFGIRLEN
IELIVKANTH YNHKNRGFLT FETVTLVPIQ TKLLDVSLLT DVEIQYLNNY HAKCLNTIKP
LLQGPENIQA LEWLERETQP LTK
//
