ID A0A2A3H0J6_9ACTN Unreviewed; 335 AA.
AC A0A2A3H0J6;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=Daunorubicin/doxorubicin resistance ABC transporter ATP-binding protein DrrA {ECO:0000313|EMBL:PBC61894.1};
GN ORFNames=BKI49_23205 {ECO:0000313|EMBL:PBC61894.1};
OS Streptomyces sp. Tue6028.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2036037 {ECO:0000313|EMBL:PBC61894.1, ECO:0000313|Proteomes:UP000217789};
RN [1] {ECO:0000313|EMBL:PBC61894.1, ECO:0000313|Proteomes:UP000217789}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tue6028 {ECO:0000313|EMBL:PBC61894.1,
RC ECO:0000313|Proteomes:UP000217789};
RA Greule A., Flemming S., Bechthold A.;
RT "The Draft Genome Sequence of Streptomyces sp. Tue6028 - Producer of
RT Polyketomycin and Foxicin.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PBC61894.1}.
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DR EMBL; MLCE01000023; PBC61894.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3H0J6; -.
DR Proteomes; UP000217789; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0043215; P:daunorubicin transport; IEA:InterPro.
DR GO; GO:1900753; P:doxorubicin transport; IEA:InterPro.
DR GO; GO:0046677; P:response to antibiotic; IEA:UniProtKB-KW.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR005894; DrrA.
DR InterPro; IPR025302; DUF4162.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR01188; drrA; 1.
DR PANTHER; PTHR42711; ABC TRANSPORTER ATP-BINDING PROTEIN; 1.
DR PANTHER; PTHR42711:SF18; DOXORUBICIN RESISTANCE ATP-BINDING PROTEIN DRRA; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF13732; DUF4162; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
PE 4: Predicted;
KW Antibiotic resistance {ECO:0000256|ARBA:ARBA00023251};
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000313|EMBL:PBC61894.1};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000217789};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT DOMAIN 5..235
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
SQ SEQUENCE 335 AA; 36111 MW; 58A736DB82BE27DB CRC64;
MPGAIYAEGL VKTFGDVRAL DGVDLDVPEG TVLGLLGPNG AGKTTAVRCL TTLLRPDSGK
AVVAGVDVLK NPDAVRRRVG LSGQFAAVDE YLTGRENLQM VGQLYQMKAK AAKVRAEELL
EQFNLSDAAD RTAKTYSGGM RRRLDLAAAL VVSPPVMFMD EPTTGLDPRN RQQLWDVIKQ
LVSGGTTLLL TTQYLEEADH LAHDICVVDH GRVIARGTAD QLKAQTGGER VEVVVHDREH
MATASEVLRG FGKGETTVEE HTRKLTVPVT GGAKLLAEVI RELDTRGIEI DDIGLRRPTL
DDVFLSLTGH LAEAKDEDIS AADGTGRQRK KEAGK
//
