ID   A0A2A3H568_9ACTN        Unreviewed;       313 AA.
AC   A0A2A3H568;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=23S rRNA (Guanosine(2251)-2'-O)-methyltransferase RlmB {ECO:0000313|EMBL:PBC62892.1};
GN   ORFNames=BKI49_16735 {ECO:0000313|EMBL:PBC62892.1};
OS   Streptomyces sp. Tue6028.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=2036037 {ECO:0000313|EMBL:PBC62892.1, ECO:0000313|Proteomes:UP000217789};
RN   [1] {ECO:0000313|EMBL:PBC62892.1, ECO:0000313|Proteomes:UP000217789}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Tue6028 {ECO:0000313|EMBL:PBC62892.1,
RC   ECO:0000313|Proteomes:UP000217789};
RA   Greule A., Flemming S., Bechthold A.;
RT   "The Draft Genome Sequence of Streptomyces sp. Tue6028 - Producer of
RT   Polyketomycin and Foxicin.";
RL   Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the class IV-like SAM-binding methyltransferase
CC       superfamily. RNA methyltransferase TrmH family.
CC       {ECO:0000256|ARBA:ARBA00007228}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PBC62892.1}.
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DR   EMBL; MLCE01000019; PBC62892.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A3H568; -.
DR   Proteomes; UP000217789; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProt.
DR   GO; GO:0003723; F:RNA binding; IEA:InterPro.
DR   GO; GO:0008173; F:RNA methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   GO; GO:0006396; P:RNA processing; IEA:InterPro.
DR   CDD; cd18103; SpoU-like_RlmB; 1.
DR   Gene3D; 3.30.1330.30; -; 1.
DR   Gene3D; 3.40.1280.10; -; 1.
DR   InterPro; IPR029028; Alpha/beta_knot_MTases.
DR   InterPro; IPR029064; Ribosomal_eL30-like_sf.
DR   InterPro; IPR004441; rRNA_MeTrfase_TrmH.
DR   InterPro; IPR001537; SpoU_MeTrfase.
DR   InterPro; IPR013123; SpoU_subst-bd.
DR   InterPro; IPR029026; tRNA_m1G_MTases_N.
DR   NCBIfam; TIGR00186; rRNA_methyl_3; 1.
DR   PANTHER; PTHR46429; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR   PANTHER; PTHR46429:SF1; 23S RRNA (GUANOSINE-2'-O-)-METHYLTRANSFERASE RLMB; 1.
DR   Pfam; PF00588; SpoU_methylase; 1.
DR   Pfam; PF08032; SpoU_sub_bind; 1.
DR   SMART; SM00967; SpoU_sub_bind; 1.
DR   SUPFAM; SSF75217; alpha/beta knot; 1.
DR   SUPFAM; SSF55315; L30e-like; 1.
PE   3: Inferred from homology;
KW   Methyltransferase {ECO:0000313|EMBL:PBC62892.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000217789};
KW   Transferase {ECO:0000313|EMBL:PBC62892.1}.
FT   DOMAIN          71..148
FT                   /note="RNA 2-O ribose methyltransferase substrate binding"
FT                   /evidence="ECO:0000259|SMART:SM00967"
FT   REGION          1..72
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   313 AA;  32829 MW;  F5C6D02FECF719A7 CRC64;
     MAANNRRMSG KKGAQIGSGG QRRRGLEGKG PTPPAEMRKG HKKNRIATAK TKQAQRRPAP
     RGRGGKGTSE MVVGRNPVVE ALREGVPATM LYVQQFIDND ERVREALQLA GERGGIHLME
     APRTELDRMT NGLNHQGLVL QVPPYEYAHP EDLAAAAYDE GADPLIVALD GVTDPRNLGA
     VVRSVSAFGG HGVVVPERRA AGMTAGAWKT SAGAAARTPV ARASNLTRAL EAYKKAGLMV
     VGLAADGEVE LGELEALGGP VVIVVGSEGK GLSRLVGETC DFRVRIPMPG GAESLNAGVA
     AGVVLYEAAR RRA
//