ID A0A2A3H8T2_9ACTN Unreviewed; 516 AA.
AC A0A2A3H8T2;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Choline oxidase {ECO:0000313|EMBL:PBC64973.1};
GN ORFNames=BKI49_04775 {ECO:0000313|EMBL:PBC64973.1};
OS Streptomyces sp. Tue6028.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=2036037 {ECO:0000313|EMBL:PBC64973.1, ECO:0000313|Proteomes:UP000217789};
RN [1] {ECO:0000313|EMBL:PBC64973.1, ECO:0000313|Proteomes:UP000217789}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Tue6028 {ECO:0000313|EMBL:PBC64973.1,
RC ECO:0000313|Proteomes:UP000217789};
RA Greule A., Flemming S., Bechthold A.;
RT "The Draft Genome Sequence of Streptomyces sp. Tue6028 - Producer of
RT Polyketomycin and Foxicin.";
RL Submitted (OCT-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=FAD; Xref=ChEBI:CHEBI:57692;
CC Evidence={ECO:0000256|PIRSR:PIRSR000137-2};
CC -!- SIMILARITY: Belongs to the GMC oxidoreductase family.
CC {ECO:0000256|ARBA:ARBA00010790}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PBC64973.1}.
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DR EMBL; MLCE01000006; PBC64973.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3H8T2; -.
DR Proteomes; UP000217789; Unassembled WGS sequence.
DR GO; GO:0050660; F:flavin adenine dinucleotide binding; IEA:InterPro.
DR GO; GO:0016614; F:oxidoreductase activity, acting on CH-OH group of donors; IEA:InterPro.
DR Gene3D; 3.30.410.40; -; 1.
DR Gene3D; 3.50.50.60; FAD/NAD(P)-binding domain; 1.
DR InterPro; IPR036188; FAD/NAD-bd_sf.
DR InterPro; IPR012132; GMC_OxRdtase.
DR InterPro; IPR000172; GMC_OxRdtase_N.
DR InterPro; IPR007867; GMC_OxRtase_C.
DR PANTHER; PTHR11552; GLUCOSE-METHANOL-CHOLINE GMC OXIDOREDUCTASE; 1.
DR PANTHER; PTHR11552:SF152; OXIDASE (CODA), PUTATIVE (AFU_ORTHOLOGUE AFUA_8G04090)-RELATED; 1.
DR Pfam; PF05199; GMC_oxred_C; 1.
DR Pfam; PF00732; GMC_oxred_N; 1.
DR PIRSF; PIRSF000137; Alcohol_oxidase; 2.
DR SUPFAM; SSF54373; FAD-linked reductases, C-terminal domain; 1.
DR SUPFAM; SSF51905; FAD/NAD(P)-binding domain; 1.
DR PROSITE; PS00624; GMC_OXRED_2; 1.
PE 3: Inferred from homology;
KW FAD {ECO:0000256|PIRSR:PIRSR000137-2};
KW Flavoprotein {ECO:0000256|PIRSR:PIRSR000137-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000217789}.
FT DOMAIN 258..272
FT /note="Glucose-methanol-choline oxidoreductase N-terminal"
FT /evidence="ECO:0000259|PROSITE:PS00624"
FT BINDING 84
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
FT BINDING 486
FT /ligand="FAD"
FT /ligand_id="ChEBI:CHEBI:57692"
FT /evidence="ECO:0000256|PIRSR:PIRSR000137-2"
SQ SEQUENCE 516 AA; 56175 MW; F97709A596072AD8 CRC64;
MSIDEFDYVV VGGGTAGNVV AARLSADPSV TVCVLEAGPS DVGDDSVLKL ERWMGLLESG
YDWDYPVEPQ TSGNSFMRHA RAKVLGGCSS HNSCIAFWAP AEDLDDWAAA GCTGWSAAEL
FPLYRRLESN DAPGDHHGRN GPVKLRTLKG EDPCGAALLE ACAQAGIPTA AFNTGTTVIR
GANWFQINSD ENNIRQSSSV AYLHPVMGKR PNLEVRTGVR AKKLVLDGRR CVGAEYLDPD
LVHTRTVRAR REVIVSCGSI DTPKLLMLSG IGPAGHLREV GVEVVVDAAG VGENLQDHPE
GVIMWEARQP MTTTSSQWWE AGIFYDTEPG LDRPDLMFHY GSVPFDMNTA RHGFPTSENA
FCLTPNVTRA KSRGTVRLRT RDYRDKPMVD PRYFTHEHDV RVMTYGLRLA RRIAGQPALS
GWTGAELAPG PDVRTDDELL DYIHKTHNTV YHPSCTVKMG ADDDASAPLD ARLRVKGIAG
LRVADGSVMP DLISVNPCIT TMMIGEKCAD LLKEDA
//
