ID   A0A2A3HNE0_9ACTN        Unreviewed;       756 AA.
AC   A0A2A3HNE0;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=RND superfamily putative drug exporter {ECO:0000313|EMBL:PBC69957.1};
GN   ORFNames=BX265_7338 {ECO:0000313|EMBL:PBC69957.1};
OS   Streptomyces sp. TLI_235.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1938860 {ECO:0000313|EMBL:PBC69957.1, ECO:0000313|Proteomes:UP000218662};
RN   [1] {ECO:0000313|EMBL:PBC69957.1, ECO:0000313|Proteomes:UP000218662}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=TLI_235 {ECO:0000313|EMBL:PBC69957.1,
RC   ECO:0000313|Proteomes:UP000218662};
RA   Klenk H.-P.;
RT   "Sequencing the genomes of 1000 actinobacteria strains.";
RL   Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PBC69957.1}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; NSGV01000003; PBC69957.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A3HNE0; -.
DR   OrthoDB; 7051771at2; -.
DR   Proteomes; UP000218662; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR   Gene3D; 1.20.1640.10; Multidrug efflux transporter AcrB transmembrane domain; 2.
DR   InterPro; IPR004869; MMPL_dom.
DR   PANTHER; PTHR33406; MEMBRANE PROTEIN MJ1562-RELATED; 1.
DR   PANTHER; PTHR33406:SF2; MEMBRANE PROTEIN SCO6666-RELATED; 1.
DR   Pfam; PF03176; MMPL; 2.
DR   SUPFAM; SSF82866; Multidrug efflux transporter AcrB transmembrane domain; 2.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000218662};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        21..40
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        193..212
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        219..237
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        243..265
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        292..313
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        319..343
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        393..417
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        547..566
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        578..599
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        611..635
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        662..680
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        692..715
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          46..393
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   DOMAIN          489..722
FT                   /note="Membrane transport protein MMPL"
FT                   /evidence="ECO:0000259|Pfam:PF03176"
FT   REGION          736..756
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   756 AA;  78531 MW;  C6B33D8B2460B490 CRC64;
     MLSKALLRLG ASAARHPWRV IAAWLVAATL VVLAAVAFGG RNADSMTAPG LDSQRAAELI
     ERAGTGQEGM TAQVVVTPLD GAATFFDHDS ARTALTRLQT EVKRLPHVLG TSDPAGALDA
     GGDTAVRGGL VSVDGRIAVV RVQYPDQSRL SAEDLDALVD LGDRLRAELP LRIEMGGSLF
     YAFSDPDGGA SELIGLLAAA AILFLAFGSL VAAALPIGMA VFGLTVGVAT MTVLAGVTDV
     PTFAPVLGSM VGLGVGIDYA LFVLARHREY LARGLDPREA AGRAVATAGR PVVFAGGTVV
     VSILGLAVAN VPFMTVGGLA VSIVVLIMVV ASVTLLPAFL GAAGPRLARA GRIGRALQIR
     KPGRLARRRD PAAGAAHAAG WRRWIGHVSR HPVLYAVGAA GLLLTATLPV LGLRVGLPDD
     GSLPRSRTER RAYDLVAEGF GPGTNGPLVI AADPAGDPGV LDRLVATVAA DPGIASVAPP
     HIDLATGIAT LVVFPTTSPQ DKATADTIAR LRTDVLPTAI GHGPARAHVG GAAASLSDVG
     QRTSRRLPVL GAAVLAMSFL LLMLVFRSVL VPLKAVLLNL LSIGAAYGIM VAVFQWGWGG
     ALIGLEATVP IVSFIPMFLF AILFGLSMDY EVFLLSRVRE EYLRTGDNGT AIVEGVSRTA
     RIITSAALIM VAVFLSFAVA EDPSTKMFGL GLATAIFIDA TVVRMVLVPA TMTLLGRTNW
     WLPKWLDRML PRGPVGTDDT DAESTGEAPR PRLVDR
//