ID A0A2A3HPK1_9ACTN Unreviewed; 503 AA.
AC A0A2A3HPK1;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 12.
DE SubName: Full=Beta-xylosidase {ECO:0000313|EMBL:PBC70364.1};
GN ORFNames=BX265_7781 {ECO:0000313|EMBL:PBC70364.1};
OS Streptomyces sp. TLI_235.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1938860 {ECO:0000313|EMBL:PBC70364.1, ECO:0000313|Proteomes:UP000218662};
RN [1] {ECO:0000313|EMBL:PBC70364.1, ECO:0000313|Proteomes:UP000218662}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TLI_235 {ECO:0000313|EMBL:PBC70364.1,
RC ECO:0000313|Proteomes:UP000218662};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the glycosyl hydrolase 43 family.
CC {ECO:0000256|ARBA:ARBA00009865, ECO:0000256|RuleBase:RU361187}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PBC70364.1}.
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DR EMBL; NSGV01000003; PBC70364.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3HPK1; -.
DR OrthoDB; 9801455at2; -.
DR Proteomes; UP000218662; Unassembled WGS sequence.
DR GO; GO:0004553; F:hydrolase activity, hydrolyzing O-glycosyl compounds; IEA:InterPro.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR CDD; cd18617; GH43_XynB-like; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR041542; GH43_C2.
DR InterPro; IPR006710; Glyco_hydro_43.
DR InterPro; IPR023296; Glyco_hydro_beta-prop_sf.
DR PANTHER; PTHR42812; BETA-XYLOSIDASE; 1.
DR PANTHER; PTHR42812:SF12; BETA-XYLOSIDASE-RELATED; 1.
DR Pfam; PF17851; GH43_C2; 1.
DR Pfam; PF04616; Glyco_hydro_43; 1.
DR SUPFAM; SSF75005; Arabinanase/levansucrase/invertase; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
PE 3: Inferred from homology;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295, ECO:0000256|RuleBase:RU361187};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|RuleBase:RU361187};
KW Reference proteome {ECO:0000313|Proteomes:UP000218662}.
FT DOMAIN 310..498
FT /note="Beta-xylosidase C-terminal Concanavalin A-like"
FT /evidence="ECO:0000259|Pfam:PF17851"
FT ACT_SITE 22
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT ACT_SITE 178
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-1"
FT SITE 130
FT /note="Important for catalytic activity, responsible for
FT pKa modulation of the active site Glu and correct
FT orientation of both the proton donor and substrate"
FT /evidence="ECO:0000256|PIRSR:PIRSR606710-2"
SQ SEQUENCE 503 AA; 54440 MW; B1360286F2013DB1 CRC64;
MSEQIQPSGT VPNPVIPGFH PDPSVCRVGD DYYLVCSSFE YFPGIPVFHS RDLVNWTQIG
NALDRPSQLR LPRDMPSSGG IYAPTLRHHD GRFWLIVTNV GDGGNMLFTA TDPAGPWSDP
VRLPGVPGID PDLAWDEDGT CWCTVAGVSQ VRLDPTTGET LGEPYRIWSG TPGSMAPEAP
HLYRIGDYWY LMIAEGGTER GHGVSIARGL TPSGPFEPCP ANPVLTHRGT ASPIQNTGHA
DLVQAPDGSW WMVLLAVRPR GGTPGWYVLG RETFLAPVQW VDGWPVVGEV TAELPTPAWP
LHSAPAVPAR DDFDQAELHP RWISVRERPE GSCTTKERSG WLTLRAAGAS LDETDTVFVG
RRQQHLACRA STLIDPADGR GGLAVRLDEE HHYEIEAADG VVKVFARIGP LRTELATRPV
PAGAVVLGVE ILPRPTRGPR TGPDDVIFGI EEPDGTFTVL AGLDGRYLST EVAGGFTGRV
IGVYAAAGTV HFDRFDYEPL PLP
//
