ID A0A2A3HTC5_9ACTN Unreviewed; 834 AA.
AC A0A2A3HTC5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=FHA modulated ABC efflux pump with fused ATPase and integral membrane subunit {ECO:0000313|EMBL:PBC71002.1};
GN ORFNames=BX265_5567 {ECO:0000313|EMBL:PBC71002.1};
OS Streptomyces sp. TLI_235.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1938860 {ECO:0000313|EMBL:PBC71002.1, ECO:0000313|Proteomes:UP000218662};
RN [1] {ECO:0000313|EMBL:PBC71002.1, ECO:0000313|Proteomes:UP000218662}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=TLI_235 {ECO:0000313|EMBL:PBC71002.1,
RC ECO:0000313|Proteomes:UP000218662};
RA Klenk H.-P.;
RT "Sequencing the genomes of 1000 actinobacteria strains.";
RL Submitted (AUG-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PBC71002.1}.
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DR EMBL; NSGV01000002; PBC71002.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3HTC5; -.
DR Proteomes; UP000218662; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0140359; F:ABC-type transporter activity; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR CDD; cd00060; FHA; 1.
DR Gene3D; 2.60.200.20; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR013525; ABC2_TM.
DR InterPro; IPR003439; ABC_transporter-like_ATP-bd.
DR InterPro; IPR017871; ABC_transporter-like_CS.
DR InterPro; IPR000253; FHA_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR008984; SMAD_FHA_dom_sf.
DR PANTHER; PTHR48041:SF91; ABC TRANSPORTER EXPRESSED IN TRACHEA, ISOFORM A; 1.
DR PANTHER; PTHR48041; ABC TRANSPORTER G FAMILY MEMBER 28; 1.
DR Pfam; PF01061; ABC2_membrane; 1.
DR Pfam; PF00005; ABC_tran; 1.
DR Pfam; PF00498; FHA; 2.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00240; FHA; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF49879; SMAD/FHA domain; 2.
DR PROSITE; PS00211; ABC_TRANSPORTER_1; 1.
DR PROSITE; PS50893; ABC_TRANSPORTER_2; 1.
DR PROSITE; PS50006; FHA_DOMAIN; 2.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000218662};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 587..607
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 619..636
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 657..684
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 704..726
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 733..753
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 801..824
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 82..131
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 192..242
FT /note="FHA"
FT /evidence="ECO:0000259|PROSITE:PS50006"
FT DOMAIN 278..512
FT /note="ABC transporter"
FT /evidence="ECO:0000259|PROSITE:PS50893"
FT REGION 546..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 550..564
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 834 AA; 89839 MW; 0A68DAE6E18D84DA CRC64;
MCGRQYEHVM PQDIPGDTPD SGRITLPWAC RGHVGPGSGS GRAVRGAATI GGMGERPAAL
TAPQLVLETD GDSQVISPSR TYHVGRDPTS EVFLDDPRVS WHHAVLHADG DHWALDDSGS
TNGTFTDGHR IRHLDVGPGS EMRFGAAADG PRCSLRALAV RTEPDRQPSA LTSITGSLRP
PTTVRPLPAK VVRIGRALEN DLVVGDLSVS RRHAELRARP DGRFEIIDVG SHNGTYVNGQ
PVLGAVVGEG DLIGIGHSVF CLVGDELQQF VDTGDVDLDV DGLTVTVAGG RRLLDSVTFP
VGQKTLLAVA GPSGAGKSTL LNALTGLRPA DEGAVRYDGR DLYRDYAELR RRIGLVPQDD
ILHTQLQVRR ALQYAAELRF PDDTAAAERE ARVEEVIGEL GLNKRADQVI SSLSGGQRKR
VSVALELLTK PSLLFLDEPT SGLDPGMDRS VMQMLRNLAD DGRTVIVVTH SVLSLELCDR
LLLLAPGGRI AFYGPPGETL GFFGFEQWPD AFDAFENDTE RDWAGQYRSS PSYRRYIAGA
MDHPGPAAPH APAAETPAPK PPRPQRWRKQ VSTLVRRYAT ALTADRTFLA VMIALPFVMG
VMARALAGKK LAEDSIFNAL LILCVGAVLT GAANSVRELV KERVIYQRER AVGLSRSAYL
CSKIIVLGTV TVIQAVVLTM VALLGVDLRP QGGSGVLMPP LLEITLAVAL LAFTAMMLGL
LISALVKKEE VTMPLLVLVA IVQVVFCGAL IQLNSTPVLA QLSWLVPSRW AFAAMAATID
LHATVPKPLT SDPLFQHKAS IWLLDMGMMV VLSVVLGLLV ARLLRRHEPA VMRR
//
