ID A0A2A3N2Z8_CAPSP Unreviewed; 580 AA.
AC A0A2A3N2Z8;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE SubName: Full=Mechanosensitive ion channel protein MscS {ECO:0000313|EMBL:PBN46103.1};
GN ORFNames=CDC50_08775 {ECO:0000313|EMBL:PBN46103.1};
OS Capnocytophaga sputigena.
OC Bacteria; Bacteroidota; Flavobacteriia; Flavobacteriales;
OC Flavobacteriaceae; Capnocytophaga.
OX NCBI_TaxID=1019 {ECO:0000313|EMBL:PBN46103.1, ECO:0000313|Proteomes:UP000218560};
RN [1] {ECO:0000313|EMBL:PBN46103.1, ECO:0000313|Proteomes:UP000218560}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=H6490 {ECO:0000313|EMBL:PBN46103.1,
RC ECO:0000313|Proteomes:UP000218560};
RA Gulvik C.A.;
RT "Capnocytophaga spp. assemblies.";
RL Submitted (JUN-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the MscS (TC 1.A.23) family.
CC {ECO:0000256|ARBA:ARBA00008017}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PBN46103.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; NIBW01000002; PBN46103.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3N2Z8; -.
DR Proteomes; UP000218560; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0008381; F:mechanosensitive monoatomic ion channel activity; IEA:InterPro.
DR Gene3D; 1.10.287.1260; -; 1.
DR Gene3D; 2.30.30.60; -; 1.
DR Gene3D; 3.30.70.100; -; 1.
DR InterPro; IPR010920; LSM_dom_sf.
DR InterPro; IPR049278; MS_channel_C.
DR InterPro; IPR045275; MscS_archaea/bacteria_type.
DR InterPro; IPR023408; MscS_beta-dom_sf.
DR InterPro; IPR006685; MscS_channel_2nd.
DR InterPro; IPR011066; MscS_channel_C_sf.
DR PANTHER; PTHR30221:SF18; SLL0590 PROTEIN; 1.
DR PANTHER; PTHR30221; SMALL-CONDUCTANCE MECHANOSENSITIVE CHANNEL; 1.
DR Pfam; PF00924; MS_channel_2nd; 1.
DR Pfam; PF21082; MS_channel_3rd; 1.
DR SUPFAM; SSF82689; Mechanosensitive channel protein MscS (YggB), C-terminal domain; 1.
DR SUPFAM; SSF50182; Sm-like ribonucleoproteins; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 195..216
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 254..279
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 356..375
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 387..415
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 402..467
FT /note="Mechanosensitive ion channel MscS"
FT /evidence="ECO:0000259|Pfam:PF00924"
FT DOMAIN 478..560
FT /note="Mechanosensitive ion channel MscS C-terminal"
FT /evidence="ECO:0000259|Pfam:PF21082"
SQ SEQUENCE 580 AA; 66631 MW; 26869273A30CE797 CRC64;
MHLKIFVFIY LFCVAYIQAQ QPDSLSQQEI RKELETIKQF RQKDSIRIAM LLNEIQLLIN
NEKNTPSITN SSTTNEKEIE KLRNKMRGRP IVFEKDTLYY LYTSYGPYDI DTRVKYVEEK
LEELYNDLYF VADSIKIKPA GDYLSVMYND KTITGVSIVD ALWENSSQTE LAQRYANIIK
NTIVKYKEQN SLKSVLIRLA ELLLVLFITF ILVWAINRLF DFLKKITLNS EHRFLTSIRI
RNYDFIKKPG IVKALVKILA ILRIVFLLFL LITIIPLIFD IFSSTQYLSK IIVQWISEPI
KNVGIAIIGY LPHLFYIVII AVITRYVLKI LRFFALEIER GILKIKGFHP EWAHTTYVLA
RMMLWVLALV IMFPHLPGSD SDAFKGISIF LGVLISLGSS SAISNAIAGI VISYMRPFQV
GDWIKSGEII GAVIEKNALV TRLKTINNED ITIPNSAILS GATMNFTSIG KEIGLALNVQ
VKVRYDYSDN LVEELLIEAA LKTNGISPKP HPYIFQISLS ELNAVYELNA YTFHPENMYF
IKSDLTKNIQ STFRQANIEI FSTQYVEIRT PFSNTKKQNP
//
