ID A0A2A3U8C3_9SPHI Unreviewed; 1007 AA.
AC A0A2A3U8C3;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=CNR22_06470 {ECO:0000313|EMBL:PBQ31421.1};
OS Sphingobacteriaceae bacterium.
OC Bacteria; Bacteroidota; Sphingobacteriia; Sphingobacteriales;
OC Sphingobacteriaceae.
OX NCBI_TaxID=2021370 {ECO:0000313|EMBL:PBQ31421.1, ECO:0000313|Proteomes:UP000217505};
RN [1] {ECO:0000313|EMBL:PBQ31421.1, ECO:0000313|Proteomes:UP000217505}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=SH-48 {ECO:0000313|EMBL:PBQ31421.1,
RC ECO:0000313|Proteomes:UP000217505};
RA Choi A.;
RT "Draft genome sequence of sphingobacterial strain SH-48, isolated from
RT freshwater in Korea.";
RL Submitted (SEP-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PBQ31421.1}.
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DR EMBL; NVQB01000001; PBQ31421.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3U8C3; -.
DR OrthoDB; 9803237at2; -.
DR Proteomes; UP000217505; Unassembled WGS sequence.
DR GO; GO:0008408; F:3'-5' exonuclease activity; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR Gene3D; 1.10.150.870; -; 1.
DR Gene3D; 3.20.20.140; Metal-dependent hydrolases; 2.
DR InterPro; IPR011708; DNA_pol3_alpha_NTPase_dom.
DR InterPro; IPR040982; DNA_pol3_finger.
DR InterPro; IPR004805; DnaE2/DnaE/PolC.
DR InterPro; IPR029460; DNAPol_HHH.
DR InterPro; IPR004013; PHP_dom.
DR InterPro; IPR003141; Pol/His_phosphatase_N.
DR NCBIfam; TIGR00594; polc; 1.
DR PANTHER; PTHR32294; DNA POLYMERASE III SUBUNIT ALPHA; 1.
DR Pfam; PF07733; DNA_pol3_alpha; 1.
DR Pfam; PF17657; DNA_pol3_finger; 1.
DR Pfam; PF14579; HHH_6; 1.
DR Pfam; PF02811; PHP; 1.
DR SMART; SM00481; POLIIIAc; 1.
PE 4: Predicted;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000217505};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 1..68
FT /note="Polymerase/histidinol phosphatase N-terminal"
FT /evidence="ECO:0000259|SMART:SM00481"
FT REGION 986..1007
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1007 AA; 115985 MW; F8A6A79F621AD127 CRC64;
MLLNSHTYYS FGYGTLSIKT LLRETWNKGY SSFVLSDINN TSAILETLRL CDGKQMKPIP
GIDFRNGIKP CYIGISKNNA GFRELNEHLS YHLHNKIEFK IRPQNKEELK NTFLVYPLSA
FDGNELEENE FIGVTPKQLR LLPLSKHKHL TSKMVVLQSF SFLDENYFEA HQVLRAIDLN
TLFSKLRSED QGSLEEIAPT KDELYEKYAD YPEIIKNTEF ILDSCSVKFE FGKLTNKNPK
FYKGSLEEDV KLLREEATKG LAYRYSEVTQ EVKDRLEKEL SIITSKEFTS YFLINWDITS
YARSRGFFYV GRGSGANSMV AYLLRITDVD PIDLDLYFER FINENRSNAP DFDIDFSWTD
REEMTDYIFK RFGENNRVAL LGTYSTYQHD AVIRELGKVY GLPPTEIDRV QKITQPKESD
DSVTKQILKH ASFIAGFPSH LSIHASGIII SEEPVTTYTA TNLPPKGYPT TQFSMLEAED
IGLFKFDILS QRGLGKIKDA VELIKQNKNI EIDIHDIVKF KHDEEIKKLM SIGACIGCFY
VESPAMRMLL AKLQADDYLR LVAASSIIRP GVSKSGMMNE YIVRYRKQEV RDKARAELPE
LYDLLKETYG VMVYQEDVIK IAHIFAGLSL ADADYLRRGM SWKFKQRNEF HMVKEKFFTN
CIAKGHPLTT ITNIWNQIES FANFAFSKGH SASYAVESYQ ALFLKAYHPL EYMVATLNNG
GGFYRTDLYI HEARMHGAEI LPPCINKSDV NCNINGKTIF LGLGMIASLE KEVIQNLLNE
RFENGPYTDL YNFVKRTQIS IEQLRILIRA GAFKFLPKNK KELLWEAHML ISPIKQKPQG
KELFHIEPQK YVLPALENTW QDDAYDEIEL FGFSLCSPFK LLKEPVTNTL VSKDLKSRRG
ETVEIVGYLV NVKTTWTHTK EKMNFGTFLD LDGHWIDTVH FPPSARAFPF SGPGCYKLTG
KVVEEFDFIY IDISHQQRLA VSNRDDDSGL RILPPRGERT REYHQRK
//
