ID   A0A2A3XBL8_9GAMM        Unreviewed;       395 AA.
AC   A0A2A3XBL8;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   27-MAR-2024, entry version 33.
DE   SubName: Full=Formaldehyde dehydrogenase, glutathione-independent {ECO:0000313|EMBL:PCC21069.1};
GN   Name=fdhA {ECO:0000313|EMBL:PCC21069.1};
GN   ORFNames=CIK78_02655 {ECO:0000313|EMBL:PCC21069.1};
OS   Halomonas sp. JB37.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=2024405 {ECO:0000313|EMBL:PCC21069.1, ECO:0000313|Proteomes:UP000217454};
RN   [1] {ECO:0000313|EMBL:PCC21069.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JB37 {ECO:0000313|EMBL:PCC21069.1};
RX   PubMed=28644126;
RA   Bonham K.S., Wolfe B.E., Dutton R.J.;
RT   "Extensive horizontal gene transfer in cheese-associated bacteria.";
RL   Elife 6:e22144-e22144(2017).
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000256|ARBA:ARBA00001947};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PCC21069.1}.
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DR   EMBL; NRGW01000001; PCC21069.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A3XBL8; -.
DR   OrthoDB; 9773078at2; -.
DR   Proteomes; UP000217454; Unassembled WGS sequence.
DR   GO; GO:0016616; F:oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor; IEA:UniProt.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   CDD; cd08282; PFDH_like; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013154; ADH-like_N.
DR   InterPro; IPR002328; ADH_Zn_CS.
DR   InterPro; IPR007698; AlaDH/PNT_NAD(H)-bd.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR014184; HCHO_DH_non_GSH.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   NCBIfam; TIGR02819; fdhA_non_GSH; 1.
DR   PANTHER; PTHR42813:SF3; GLUTATHIONE-INDEPENDENT FORMALDEHYDE DEHYDROGENASE; 1.
DR   PANTHER; PTHR42813; ZINC-TYPE ALCOHOL DEHYDROGENASE-LIKE; 1.
DR   Pfam; PF08240; ADH_N; 1.
DR   Pfam; PF01262; AlaDh_PNT_C; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
DR   PROSITE; PS00059; ADH_ZINC; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002}.
FT   DOMAIN          35..144
FT                   /note="Alcohol dehydrogenase-like N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF08240"
FT   DOMAIN          179..237
FT                   /note="Alanine dehydrogenase/pyridine nucleotide
FT                   transhydrogenase NAD(H)-binding"
FT                   /evidence="ECO:0000259|Pfam:PF01262"
SQ   SEQUENCE   395 AA;  41620 MW;  2F42D55E3171F42F CRC64;
     MSNNRGVVYI GDGKVEVQDI AYPKMETPNG KPIDHGVILK VVSTNICGSD QHMVRGRTTA
     PAGMVLGHEI TGEVIEKGKG VEFLSIGDIV SVPFNVACGR CRTCKEGHTG LCLHVNDDRA
     GGAYGYVDMG GWVGGQAHYV MVPYADFNLL KFPDRDQAMT QIRDLTMLSD ILPTGFHGAL
     KAGVGAGSTV YVAGAGPVGL AAAASARLLG AAVVMIGDFN QQRLEHARKM GFVPIDLSKH
     DRLGEMIAAV VGEPSVDSAI DAVGFEAIGH GGKEQPAVVL NQMMEVTREG GSIGIPGLYV
     TEDPGATEKA AQTGNLSLRF GQGWAKGLSF HTGQTPVVQY NRQLMQAILH GRLNIAEIVN
     AQVISLEDAP TGYEQFDAGV ASKFVLDPHG MLGVA
//