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Database: UniProt
Entry: A0A2A3XDN9_9GAMM
LinkDB: A0A2A3XDN9_9GAMM
Original site: A0A2A3XDN9_9GAMM 
ID   A0A2A3XDN9_9GAMM        Unreviewed;       715 AA.
AC   A0A2A3XDN9;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   24-JAN-2024, entry version 36.
DE   SubName: Full=Heavy metal translocating P-type ATPase {ECO:0000313|EMBL:PCC21789.1};
GN   ORFNames=CIK78_06775 {ECO:0000313|EMBL:PCC21789.1};
OS   Halomonas sp. JB37.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC   Halomonadaceae; Halomonas.
OX   NCBI_TaxID=2024405 {ECO:0000313|EMBL:PCC21789.1, ECO:0000313|Proteomes:UP000217454};
RN   [1] {ECO:0000313|EMBL:PCC21789.1}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JB37 {ECO:0000313|EMBL:PCC21789.1};
RX   PubMed=28644126;
RA   Bonham K.S., Wolfe B.E., Dutton R.J.;
RT   "Extensive horizontal gene transfer in cheese-associated bacteria.";
RL   Elife 6:e22144-e22144(2017).
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|RuleBase:RU362081}.
CC   -!- SIMILARITY: Belongs to the cation transport ATPase (P-type) (TC 3.A.3)
CC       family. Type IB subfamily. {ECO:0000256|ARBA:ARBA00006024,
CC       ECO:0000256|RuleBase:RU362081}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:PCC21789.1}.
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DR   EMBL; NRGW01000001; PCC21789.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A2A3XDN9; -.
DR   OrthoDB; 9814270at2; -.
DR   Proteomes; UP000217454; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0019829; F:ATPase-coupled monoatomic cation transmembrane transporter activity; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0015662; F:P-type ion transporter activity; IEA:UniProt.
DR   CDD; cd00371; HMA; 1.
DR   Gene3D; 3.30.70.100; -; 1.
DR   Gene3D; 3.40.1110.10; Calcium-transporting ATPase, cytoplasmic domain N; 1.
DR   Gene3D; 2.70.150.10; Calcium-transporting ATPase, cytoplasmic transduction domain A; 1.
DR   Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR   InterPro; IPR023299; ATPase_P-typ_cyto_dom_N.
DR   InterPro; IPR018303; ATPase_P-typ_P_site.
DR   InterPro; IPR023298; ATPase_P-typ_TM_dom_sf.
DR   InterPro; IPR008250; ATPase_P-typ_transduc_dom_A_sf.
DR   InterPro; IPR036412; HAD-like_sf.
DR   InterPro; IPR023214; HAD_sf.
DR   InterPro; IPR006121; HMA_dom.
DR   InterPro; IPR036163; HMA_dom_sf.
DR   InterPro; IPR027256; P-typ_ATPase_IB.
DR   InterPro; IPR001757; P_typ_ATPase.
DR   InterPro; IPR044492; P_typ_ATPase_HD_dom.
DR   NCBIfam; TIGR01511; ATPase-IB1_Cu; 1.
DR   NCBIfam; TIGR01512; ATPase-IB2_Cd; 1.
DR   NCBIfam; TIGR01525; ATPase-IB_hvy; 1.
DR   NCBIfam; TIGR01494; ATPase_P-type; 1.
DR   PANTHER; PTHR48085; CADMIUM/ZINC-TRANSPORTING ATPASE HMA2-RELATED; 1.
DR   PANTHER; PTHR48085:SF5; CADMIUM/ZINC-TRANSPORTING ATPASE HMA4-RELATED; 1.
DR   Pfam; PF00122; E1-E2_ATPase; 1.
DR   Pfam; PF00403; HMA; 1.
DR   Pfam; PF00702; Hydrolase; 1.
DR   PRINTS; PR00119; CATATPASE.
DR   PRINTS; PR00941; CDATPASE.
DR   SFLD; SFLDS00003; Haloacid_Dehalogenase; 1.
DR   SFLD; SFLDF00027; p-type_atpase; 1.
DR   SUPFAM; SSF81653; Calcium ATPase, transduction domain A; 1.
DR   SUPFAM; SSF81665; Calcium ATPase, transmembrane domain M; 1.
DR   SUPFAM; SSF56784; HAD-like; 1.
DR   SUPFAM; SSF55008; HMA, heavy metal-associated domain; 1.
DR   PROSITE; PS00154; ATPASE_E1_E2; 1.
DR   PROSITE; PS50846; HMA_2; 1.
PE   3: Inferred from homology;
KW   ATP-binding {ECO:0000256|RuleBase:RU362081};
KW   Cell membrane {ECO:0000256|RuleBase:RU362081};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU362081};
KW   Metal-binding {ECO:0000256|RuleBase:RU362081};
KW   Nucleotide-binding {ECO:0000256|RuleBase:RU362081};
KW   Translocase {ECO:0000256|ARBA:ARBA00022967};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW   ECO:0000256|RuleBase:RU362081};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|RuleBase:RU362081}.
FT   TRANSMEM        100..118
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        320..342
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        354..380
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        664..682
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   TRANSMEM        688..707
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|RuleBase:RU362081"
FT   DOMAIN          10..77
FT                   /note="HMA"
FT                   /evidence="ECO:0000259|PROSITE:PS50846"
SQ   SEQUENCE   715 AA;  75383 MW;  CA7C0BDE65EF940F CRC64;
     MSDIPLAKNQ PFTLRVQGMD CGGCERKVES ALKRLRYVES VSASAVAGSV QLTAQDGDVL
     LRQEIESTIT ALGYRIIDET SAAHDAGEAT PWWQSPKGRL VIVSGALLTL AWVLKFVWPD
     LGTWPFVAAT VVGLVPIVQR AWQALRLGNP FTIEMLMSIA ALGALAINAA AEAAVVVFLF
     AVGEMLEGVA AAQARRSISA LSKLTPSTAR LLEQGEAREV SAASLVPGQR VQVRPGDRLP
     CDGTIVDGRS HIDESPVNGE SMPREREQGE SVFAGTVNLD GVLEVEVTRS AENNTIARVI
     KLVEEAQAAK APVARFIDRF AFFYMPAVVA VALLVAIVPP LVSSMLWSES IYRALALLLI
     ACPCALVIST PAAIAAGLSV GARNGLLMKG GAVLEQLGKL KRVALDKTGT LTAGMPTVTD
     VEGLEADSSG ADVLRLAAAL EQGSSHPLAV AIGNYARHQG VQVPAVQAGH ALSGQGVAGQ
     VEGRELMLVS PRYLQRFAAR PSGWDARIEA LETQGKSLAV LLENEQPLGL IALRDEPRED
     ARSGLQALER LGVSVVMLSG DNARTVAAIG EQLGIEAEGE LMPEDKAQRV RQWQAQGLGP
     VGKVGDGIND APALAAAEVG IAMGSGTDVA LETADAALLK NRVRGIAEMI SLSRATMRNV
     KTNVVLALGF KAFFLVSTAL GITGMWVAVM ADTGATVLVT LNALYLLRYR FNDIS
//
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