ID A0A2A3XHH5_9GAMM Unreviewed; 1085 AA.
AC A0A2A3XHH5;
DT 20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT 20-DEC-2017, sequence version 1.
DT 27-MAR-2024, entry version 36.
DE RecName: Full=DNA translocase FtsK {ECO:0000256|ARBA:ARBA00020887};
GN ORFNames=CIK78_14405 {ECO:0000313|EMBL:PCC23149.1};
OS Halomonas sp. JB37.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Oceanospirillales;
OC Halomonadaceae; Halomonas.
OX NCBI_TaxID=2024405 {ECO:0000313|EMBL:PCC23149.1, ECO:0000313|Proteomes:UP000217454};
RN [1] {ECO:0000313|EMBL:PCC23149.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=JB37 {ECO:0000313|EMBL:PCC23149.1};
RX PubMed=28644126;
RA Bonham K.S., Wolfe B.E., Dutton R.J.;
RT "Extensive horizontal gene transfer in cheese-associated bacteria.";
RL Elife 6:e22144-e22144(2017).
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the FtsK/SpoIIIE/SftA family.
CC {ECO:0000256|ARBA:ARBA00006474}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:PCC23149.1}.
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DR EMBL; NRGW01000001; PCC23149.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A2A3XHH5; -.
DR OrthoDB; 9807790at2; -.
DR Proteomes; UP000217454; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-KW.
DR CDD; cd01127; TrwB_TraG_TraD_VirD4; 1.
DR Gene3D; 3.30.980.40; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR025199; FtsK_4TM.
DR InterPro; IPR041027; FtsK_alpha.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR018541; Ftsk_gamma.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR22683:SF41; DNA TRANSLOCASE FTSK; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR Pfam; PF13491; FtsK_4TM; 1.
DR Pfam; PF17854; FtsK_alpha; 1.
DR Pfam; PF09397; FtsK_gamma; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 1.
DR SMART; SM00843; Ftsk_gamma; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50901; FTSK; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000313|EMBL:PCC23149.1};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 45..67
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 97..121
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 133..158
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 164..184
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 191..212
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 722..936
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 237..483
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 508..562
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 10..27
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 302..331
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 739..746
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 1085 AA; 117135 MW; EB46D3D33820B725 CRC64;
MKVNKAASKR TQRNARQTPS SASSARVNAA KDKARRFGLR LQGSVRECVV VVLLALCVFL
LLALFSYQPS DPGWSYQGPE TDIRNWMGQV GAWLADVLYS LLGASALWWP GMFGFAAWWL
IRSRQVRFEL DPVAIAVHAG GLVLLMFGTT MLGALHFYHP NSMLPYASGG ILGEGFVAAL
KPLVGSGGVG LIAAALILSG FPLFSGMSWL QVADELGKRI CRLGGWFSAR RQARRMRAAQ
RAAAKPAPAP KPQARTETPP PAEVETVATR PAVKAPAGRE RREPGLSSAF SAYEPTADKT
PDASPSIGNT TDTSIPWEAA SLSSNKHVPV QSSAPAPVEP MADATPPSTP KAPRENAFAP
VKPRAAEPTF QISDSDEPSA AEPVVDEPAV EEPEIDKPAV DEPSNTAAAF PLRASRQDAS
SMPATTSYFV NDEAPVEKQP IETPRVEPSR ASVEPPVSEP EQRVSVSEPT PASERAAAIV
PERTPAFERV AEVVPEPVWD DEDMDDELEE APMPLTPPAA SMQPASSTSA VPPVQPVQPQ
PSTMRREPTF APEESAPETD EGPTLWTVEH LQSQRPAFET MDEPEGDVPS FQLLTPAEPH
QPNYTEEQLT DMAELLEVRL REYGVKAEVV DTWPGPVITR FEIKPAAGVK VSKISNLAKD
LARSLMVKSV RVVEVIPGRP TVGIEIPNPN RAMIRLREVI DSDRYQQETS PLTMALGQDI
GGSPVVANLG KMPHLLVAGT TGSGKSVGVN AMLISMLLKA KPSELKLIMV DPKMLELSVY
DGIPHLLAPV VTDMKEAANS LRWCVAEMER RYKLMAAMGV RNIAGFNGRL DEAERAGAQV
ADPLWEPQPW EIHQPHPVLE KLPYIVVVID EFADMFMIVG KKVEELIARL AQKARAAGIH
LILATQRPSV DVVTGLIKAN IPSRMAFQVS SRIDSRTILD QGGAESLLGH GDMLYLPAGS
GPPNRIHGAF VDDDEVHRVV DDWKRRGAPQ YIEEILSGGV TADALTGLEA DGVDGDDAEQ
DALYDEAVQF VTETRKASIS AVQRRFKIGY NRAARLVDAM ESAGVVTAMG SNGARDVLAP
PPVGH
//
