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Database: UniProt
Entry: A0A2A3XXJ2_9MICC
LinkDB: A0A2A3XXJ2_9MICC
Original site: A0A2A3XXJ2_9MICC 
ID   A0A2A3XXJ2_9MICC        Unreviewed;       969 AA.
AC   A0A2A3XXJ2;
DT   20-DEC-2017, integrated into UniProtKB/TrEMBL.
DT   20-DEC-2017, sequence version 1.
DT   05-JUN-2019, entry version 14.
DE   RecName: Full=Sarcosine oxidase subunit alpha {ECO:0000256|PIRNR:PIRNR037980};
DE            EC=1.5.3.1 {ECO:0000256|PIRNR:PIRNR037980};
GN   ORFNames=CIK76_11755 {ECO:0000313|EMBL:PCC28392.1};
OS   Glutamicibacter sp. BW80.
OC   Bacteria; Actinobacteria; Micrococcales; Micrococcaceae;
OC   Glutamicibacter.
OX   NCBI_TaxID=2024404 {ECO:0000313|EMBL:PCC28392.1, ECO:0000313|Proteomes:UP000218725};
RN   [1] {ECO:0000313|EMBL:PCC28392.1, ECO:0000313|Proteomes:UP000218725}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BW80 {ECO:0000313|EMBL:PCC28392.1,
RC   ECO:0000313|Proteomes:UP000218725};
RX   PubMed=28644126;
RA   Bonham K.S., Wolfe B.E., Dutton R.J.;
RT   "Extensive horizontal gene transfer in cheese-associated bacteria.";
RL   Elife 6:e22144-e22144(2017).
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H2O + O2 + sarcosine = formaldehyde + glycine + H2O2;
CC         Xref=Rhea:RHEA:13313, ChEBI:CHEBI:15377, ChEBI:CHEBI:15379,
CC         ChEBI:CHEBI:16240, ChEBI:CHEBI:16842, ChEBI:CHEBI:57305,
CC         ChEBI:CHEBI:57433; EC=1.5.3.1;
CC         Evidence={ECO:0000256|PIRNR:PIRNR037980};
CC   -!- COFACTOR:
CC       Name=FAD; Xref=ChEBI:CHEBI:57692;
CC         Evidence={ECO:0000256|PIRNR:PIRNR037980};
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|PIRNR:PIRNR037980}.
CC   -!- SIMILARITY: Belongs to the GcvT family.
CC       {ECO:0000256|PIRNR:PIRNR037980, ECO:0000256|SAAS:SAAS01192594}.
CC   -!- CAUTION: The sequence shown here is derived from an
CC       EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is
CC       preliminary data. {ECO:0000313|EMBL:PCC28392.1}.
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DR   EMBL; NRGV01000039; PCC28392.1; -; Genomic_DNA.
DR   Proteomes; UP000218725; Unassembled WGS sequence.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0008115; F:sarcosine oxidase activity; IEA:UniProtKB-UniRule.
DR   GO; GO:0046653; P:tetrahydrofolate metabolic process; IEA:UniProtKB-UniRule.
DR   Gene3D; 1.10.10.1100; -; 1.
DR   Gene3D; 3.30.1360.120; -; 1.
DR   Gene3D; 3.50.50.60; -; 2.
DR   InterPro; IPR041854; BFD-like_2Fe2S-bd_dom_sf.
DR   InterPro; IPR036188; FAD/NAD-bd_sf.
DR   InterPro; IPR013977; GCV_T_C.
DR   InterPro; IPR006222; GCV_T_N.
DR   InterPro; IPR029043; GcvT/YgfZ_C.
DR   InterPro; IPR006277; Sarcosine_oxidase_asu.
DR   InterPro; IPR041117; SoxA_A3.
DR   InterPro; IPR027266; TrmE/GcvT_dom1.
DR   Pfam; PF01571; GCV_T; 1.
DR   Pfam; PF08669; GCV_T_C; 1.
DR   Pfam; PF17806; SO_alpha_A3; 1.
DR   PIRSF; PIRSF037980; SoxA; 2.
DR   SUPFAM; SSF101790; SSF101790; 1.
DR   SUPFAM; SSF51905; SSF51905; 1.
DR   TIGRFAMs; TIGR01372; soxA; 1.
PE   3: Inferred from homology;
KW   Complete proteome {ECO:0000313|Proteomes:UP000218725};
KW   Cytoplasm {ECO:0000256|PIRNR:PIRNR037980};
KW   FAD {ECO:0000256|PIRNR:PIRNR037980};
KW   Flavoprotein {ECO:0000256|PIRNR:PIRNR037980};
KW   Oxidoreductase {ECO:0000256|PIRNR:PIRNR037980}.
FT   DOMAIN      482    566       SO_alpha_A3. {ECO:0000259|Pfam:PF17806}.
FT   DOMAIN      581    848       GCV_T. {ECO:0000259|Pfam:PF01571}.
FT   DOMAIN      872    961       GCV_T_C. {ECO:0000259|Pfam:PF08669}.
SQ   SEQUENCE   969 AA;  103119 MW;  CA32944DA892BDA1 CRC64;
     MSTTDSYRLD AAQAADARVD YAQPLDVKLN EKPLSALRGD TLASAMLASG IRRVGDSLYL
     KRPRGIFAAG VEEPNALVHI HARHSDDVDE SMLAAPVVPA AQGLSARTLS GLGTMDPRKD
     EAYYDHAHVH TDVLVVGAGP AGLAAAREAA RSGARVMLLD ERAEAGGRLL DAPDEQIDGI
     DSCQWIAQVT AELDAAEETT HLQHTTALGS YDSNYVIAVQ RRTAPLDDAP APGVSRERVW
     HIRAGQVVLA TGAHERPLVF ENNDRPGIML AGAVRSYLNR YGVRAGSQIL VATTNDSVYP
     LVTELAASGG VVAVVDAREN VSVAAAEAVG AGVHVITGSV VVDTEAGANG ELSAVWVASL
     DAQNDIGAAQ RLEADTLAIS GGFNPVVHLH SQRQGKLAWD ATVHAFLPAA PVANQHLAGS
     LTGRFDTAGA LAGGAAAGAA AATAAGFETI ARVPEAIEVA LGETRPVWLV PSRQGEDAVH
     YKHHFVDLQR DQTVAEVLRS TGAGMRSVEH VKRYTSISTA NDQGKTSGVA AIGVIAAVLG
     IENPAEIGTT TFRAPYTPVS FVALAGRNRG QLLDPARVTA MHPWHLAQGA AFEDVGQWKR
     PWYYPQPGES MDEAVYRECA AVRDSVGMLD ASTLGKIEIR GADAAEFLNR IYTNGYTKLK
     VGMGRYGVMC HADGMIFDDG VTLRLAQDRF LMHTTTGGAA EVLDWLEEWL QTEWPELDVV
     CTSVTEQLAT VAVVGPKSRA VISKLAPELD VSNEAFKFMA FADTTLENGT PARISRISFS
     GELAFEIAVP SWYGLGTWEA VYAAGEEYNI TPYGTETMHV LRAEKGFIIV GQDTDGTVTP
     QDAAMGWVVS KLKDFVGNRS FSRDDNQRTD RKQLVSVLPV DKTLRLPEGT ALVGAGTPFT
     PADGPVPMEG WVTSSYNSPA LGRTFGLALI KNGFNRIGEV LKAPVGDQLV DVEVCETVLY
     DPEGSRRDG
//
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